Sema3E, a ligand for PlexinD1, controls angiogenesis and promotes cancer invasion and metastasis. In this issue of Cancer Cell, Luchino and colleagues report that Sema3E also ensures breast cancer cell viability byblocking a previously unknown proapoptotic signaling cascade elicited by unliganded PlexinD1, thus behaving as a "dependence receptor.". © 2013 Elsevier Inc.
Tamagnone, L., Rehman, M., To Die or Not to Die: Sema3E Rules the Game, <<CANCER CELL>>, 2013; 24 (5): 564-566. [doi:10.1016/j.ccr.2013.10.010] [http://hdl.handle.net/10807/139698]
To Die or Not to Die: Sema3E Rules the Game
Tamagnone, Luca
;
2013
Abstract
Sema3E, a ligand for PlexinD1, controls angiogenesis and promotes cancer invasion and metastasis. In this issue of Cancer Cell, Luchino and colleagues report that Sema3E also ensures breast cancer cell viability byblocking a previously unknown proapoptotic signaling cascade elicited by unliganded PlexinD1, thus behaving as a "dependence receptor.". © 2013 Elsevier Inc.
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