Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo- and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand-linked quaternary transition of hemoglobin in the control of "NO bioactivity" and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule

De Rosa, M. C., Carelli Alinovi, C., Galtieri, A., Russo, A., Giardina, B., Allosterich properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in Gas Transport and Metabolic Modulation, <<IUBMB LIFE>>, 2008; (60): 87-93 [http://hdl.handle.net/10807/13872]

Allosterich properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in Gas Transport and Metabolic Modulation

De Rosa, Maria Cristina;Carelli Alinovi, Cristiana;Russo, Andrea;Giardina, Bruno
2008

Abstract

Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo- and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand-linked quaternary transition of hemoglobin in the control of "NO bioactivity" and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule
Inglese
De Rosa, M. C., Carelli Alinovi, C., Galtieri, A., Russo, A., Giardina, B., Allosterich properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in Gas Transport and Metabolic Modulation, <<IUBMB LIFE>>, 2008; (60): 87-93 [http://hdl.handle.net/10807/13872]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/13872
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