Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.
Bronte, V., Tortora, G., Adipocytes and neutrophils give a helping hand to pancreatic cancers, <<CANCER DISCOVERY>>, 2016; 6 (8): 821-823. [doi:10.1158/2159-8290.CD-16-0682] [http://hdl.handle.net/10807/134265]
Adipocytes and neutrophils give a helping hand to pancreatic cancers
Tortora, Giampaolo
2016
Abstract
Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight.
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