A 75-year-old man, who had been diagnosed with small lymphocytic lymphoma with cervical localization, underwent 18F-FDG PET/CT with iodinated contrast medium due to the appearance of cervical swelling suspected of illness relapse. PET/CT revealed intense 18F-FDG uptake in multiple cervical and subdiaphragmatic lymph nodes and in the left parotid. Moreover, diffuse uptake and wall thickening of the colon were evident; endoscopy with biopsy revealed a diffuse large B-cell lymphoma. Transformation into a more aggressive lymphoma occurs in 2% to 8% of small lymphocytic lymphoma, the so-called Richter syndrome. Extranodal localization in the sigmoid colon is an extremely rare site for transformed lymphoma.
Lavalle, M., Minordi, L. M., Hohaus, S., Manfredi, R., Rufini, V., Richter Syndrome Presenting With Colon Localization, <<CLINICAL NUCLEAR MEDICINE>>, 2019; 2019 (44(2)): e87-e89. [doi:10.1097/RLU.0000000000002393] [http://hdl.handle.net/10807/133649]
Richter Syndrome Presenting With Colon Localization
Minordi, Laura MariaSecondo
Methodology
;Hohaus, StefanValidation
;Manfredi, RiccardoPenultimo
Supervision
;Rufini, VittoriaUltimo
Supervision
2019
Abstract
A 75-year-old man, who had been diagnosed with small lymphocytic lymphoma with cervical localization, underwent 18F-FDG PET/CT with iodinated contrast medium due to the appearance of cervical swelling suspected of illness relapse. PET/CT revealed intense 18F-FDG uptake in multiple cervical and subdiaphragmatic lymph nodes and in the left parotid. Moreover, diffuse uptake and wall thickening of the colon were evident; endoscopy with biopsy revealed a diffuse large B-cell lymphoma. Transformation into a more aggressive lymphoma occurs in 2% to 8% of small lymphocytic lymphoma, the so-called Richter syndrome. Extranodal localization in the sigmoid colon is an extremely rare site for transformed lymphoma.
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