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EnglishXanthan gum-based microspheres and hydrogels, useful for targeted colorectal release of omega-3 polyunsaturated fatty acids (PUFAs), were successfully prepared and characterized. In particular, the microsphere size,as well as the hidrogel swelling degree at pH7.4, and the omega-3 PUFA loading efficiency of both the materials suggested their suitability for colorectal delivery. Moreover, the antioxidant efficiency of the xanthan gum based materials suggests their ability to protect the omega-PUFA cargo. We demonstrated that α-linolenic acid (ALA 18:3ω-3) carried by the materials increased significantly its ability to reduce colorectal cancer cell growth in vitro.On the contrary, docosahexaenoic acid (DHA, 22:6ω-3) enclosed in the hydrogel formulation did not enhance its already high anti-neoplastic potential. The improved anti-neoplastic efficacy of ALA enclosed in both the xanthan gum-based formulations further supports the hypothesis of a potential use of this omega-3 PUFA as a suitable and more sustainable alternative to thefish-derived DHA.
Trombino, S., Serini, S., Cassano, R., Calviello, G., Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation., <<CARBOHYDRATE POLYMERS>>, 2019; (208): 431-440. [doi:10.1016/j.carbpol.2019.01.001] [http://hdl.handle.net/10807/132069]
| Autori: | ||
| Titolo: | Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation. | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.carbpol.2019.01.001 | |
| Data di pubblicazione: | 2019 | |
| Abstract: | Xanthan gum-based microspheres and hydrogels, useful for targeted colorectal release of omega-3 polyunsaturated fatty acids (PUFAs), were successfully prepared and characterized. In particular, the microsphere size,as well as the hidrogel swelling degree at pH7.4, and the omega-3 PUFA loading efficiency of both the materials suggested their suitability for colorectal delivery. Moreover, the antioxidant efficiency of the xanthan gum based materials suggests their ability to protect the omega-PUFA cargo. We demonstrated that α-linolenic acid (ALA 18:3ω-3) carried by the materials increased significantly its ability to reduce colorectal cancer cell growth in vitro.On the contrary, docosahexaenoic acid (DHA, 22:6ω-3) enclosed in the hydrogel formulation did not enhance its already high anti-neoplastic potential. The improved anti-neoplastic efficacy of ALA enclosed in both the xanthan gum-based formulations further supports the hypothesis of a potential use of this omega-3 PUFA as a suitable and more sustainable alternative to thefish-derived DHA. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Trombino, S., Serini, S., Cassano, R., Calviello, G., Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation., <<CARBOHYDRATE POLYMERS>>, 2019; (208): 431-440. [doi:10.1016/j.carbpol.2019.01.001] [http://hdl.handle.net/10807/132069] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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| Trombino et al., Carb Polym 2019.pdf | Versione Editoriale (PDF) | Nessuna Nota | Non specificato | Administrator |
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