The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.
Fusco, A., Bianchi, A., Mancini, A., Milardi, D., Giampietro, A., Cimino, V., Porcelli, T., Romualdi, D., Guido, M., Lanzone, A., Pontecorvi, A., De Marinis, L., Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome, <<JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION>>, 2007; 30 (11): 948-956 [http://hdl.handle.net/10807/13193]
Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome
Fusco, Alessandra;Bianchi, Antonio;Mancini, A;Milardi, Domenico;Giampietro, Antonella;Romualdi, Daniela;Guido, Maurizio;Lanzone, Antonio;Pontecorvi, Alfredo;De Marinis, Laura
2007
Abstract
The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.
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