A fatality following the ingestion of ibupofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug (NSAID) widely prescribed as an analgesic, anti-inflammatory and anti-pyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. Here we report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the ED by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt. Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidon, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the ED, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography-mass spectrometry (GC/MS) technique. The estimated ibuprofen concentration in plasma was 600 mcg/ml; gastric content were 200 mcg/ml for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.

Lodise, M., De Giorgio, F., Rossi, R., Fucci, N., Acute Ibuprofen Intoxication: report on a case and review of the literature, <<THE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY>>, 2012; (N/A): N/A-N/A. [doi:10.1097/PAF.0b013e318253d6ff] [https://hdl.handle.net/10807/13113]

Acute Ibuprofen Intoxication: report on a case and review of the literature

Lodise, Maria;De Giorgio, Fabio;Rossi, Riccardo;Fucci, Nadia
2012

Abstract

A fatality following the ingestion of ibupofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug (NSAID) widely prescribed as an analgesic, anti-inflammatory and anti-pyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. Here we report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the ED by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt. Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidon, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the ED, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography-mass spectrometry (GC/MS) technique. The estimated ibuprofen concentration in plasma was 600 mcg/ml; gastric content were 200 mcg/ml for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.
Inglese
Lodise, M., De Giorgio, F., Rossi, R., Fucci, N., Acute Ibuprofen Intoxication: report on a case and review of the literature, <<THE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY>>, 2012; (N/A): N/A-N/A. [doi:10.1097/PAF.0b013e318253d6ff] [https://hdl.handle.net/10807/13113]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/13113
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