We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.

De Giorgio, F., Arena, V., Arena, E., Lodise, M., Valerio, L., D'aloja, E., Chiarotti, M., Subarachnoid hemorrhage during sexual activity after sildenafil intake: anaccidental association?, <<THE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY>>, 2011; 2011 (Aprile): 310-311 [http://hdl.handle.net/10807/13075]

Subarachnoid hemorrhage during sexual activity after sildenafil intake: an accidental association?

De Giorgio, Fabio;Arena, Vincenzo;Arena, Elisa;Lodise, Maria;D'Aloja, Ernesto;Chiarotti, Marcello
2011

Abstract

We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.
Inglese
De Giorgio, F., Arena, V., Arena, E., Lodise, M., Valerio, L., D'aloja, E., Chiarotti, M., Subarachnoid hemorrhage during sexual activity after sildenafil intake: anaccidental association?, <<THE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY>>, 2011; 2011 (Aprile): 310-311 [http://hdl.handle.net/10807/13075]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/13075
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