Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO-CU-PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin-PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans. Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing.

Palmieri, V., Bugli, F., Cacaci, M., Perini, G., De Maio, F., Delogu, G., Torelli, R., Conti, C., Sanguinetti, M., De Spirito, M., Zanoni, R., Papi, M., Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites, <<NANOMEDICINE>>, 2018; 13 (22): 2867-2879. [doi:10.2217/nnm-2018-0183] [http://hdl.handle.net/10807/129575]

Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites

Palmieri, Valentina;Bugli, Francesca;Perini, Giordano;De Maio, Flavio;Delogu, Giovanni;Torelli, Riccardo;Sanguinetti, Maurizio;De Spirito, Marco;Papi, Massimiliano
2018

Abstract

Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO-CU-PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin-PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans. Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing.
Inglese
Palmieri, V., Bugli, F., Cacaci, M., Perini, G., De Maio, F., Delogu, G., Torelli, R., Conti, C., Sanguinetti, M., De Spirito, M., Zanoni, R., Papi, M., Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites, <<NANOMEDICINE>>, 2018; 13 (22): 2867-2879. [doi:10.2217/nnm-2018-0183] [http://hdl.handle.net/10807/129575]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/129575
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