Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of "feeding-related" peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.
Leggio, L., Addolorato, G., Cippitelli, A., Jerlhag, E., Kampov Polevoy, A., Swift, R., Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin., <<ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH>>, 2011; (Febbraio): 194-202 [http://hdl.handle.net/10807/12895]
Autori: | ||
Titolo: | Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. | |
Data di pubblicazione: | 2011 | |
Abstract: | Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of "feeding-related" peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications. | |
Lingua: | Inglese | |
Rivista: | ||
Citazione: | Leggio, L., Addolorato, G., Cippitelli, A., Jerlhag, E., Kampov Polevoy, A., Swift, R., Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin., <<ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH>>, 2011; (Febbraio): 194-202 [http://hdl.handle.net/10807/12895] | |
Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |