Aim:  To investigate whether healthy women with a previous pregnancy complicated by a small for gestational age (SGA) infant have normal endothelial function, carbohydrate and lipid metabolism, and normal inflammation parameters. Material and Methods:  Brachial artery flow-mediated dilatation (FMD, endothelium-dependent) was measured in 16 subjects with previous SGA, and in 15 controls (CTR) with previous normal pregnancies. Lipid panel, glucose, insulin, tumor necrosis factor alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (s-ICAM), soluble vascular (s-VCAM-1) adhesion molecule-1 (s-VCAM-1), and androgens were also measured. Results:  FMD was reduced in women with previous SGA compared to controls (P < 0.0001). SGA women showed increased insulin resistance (P < 0.0001), s-ICAM-1 (P = 0.008), TNF-alpha (P = 0.02), testosterone (P = 0.03), and diastolic blood pressure (P = 0.01) than CTR. Conclusion:  Endothelial dysfunction, reduced insulin sensitivity and subclinical inflammation are present in otherwise healthy women with previous SGA. These abnormalities show that the presence of a SGA infant in the obstetric history should be considered as a risk factor for cardiovascular disease later in life.

Paradisi, G., Mattoli, M. V., Tomei, C., Zuppi, C., Lulli, P., Quagliozzi, L., Caruso, A., Cardiovascular risk factors in healthy women with previous small for gestational age infants., <<THE JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH>>, 2011; (Maggio): 1397-1404 [http://hdl.handle.net/10807/12847]

Cardiovascular risk factors in healthy women with previous small for gestational age infants.

Paradisi, Giancarlo;Mattoli, Maria Vittoria;Tomei, Claudia;Zuppi, Cecilia;Lulli, Paola;Quagliozzi, Lorena;Caruso, Alessandro
2011

Abstract

Aim:  To investigate whether healthy women with a previous pregnancy complicated by a small for gestational age (SGA) infant have normal endothelial function, carbohydrate and lipid metabolism, and normal inflammation parameters. Material and Methods:  Brachial artery flow-mediated dilatation (FMD, endothelium-dependent) was measured in 16 subjects with previous SGA, and in 15 controls (CTR) with previous normal pregnancies. Lipid panel, glucose, insulin, tumor necrosis factor alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (s-ICAM), soluble vascular (s-VCAM-1) adhesion molecule-1 (s-VCAM-1), and androgens were also measured. Results:  FMD was reduced in women with previous SGA compared to controls (P < 0.0001). SGA women showed increased insulin resistance (P < 0.0001), s-ICAM-1 (P = 0.008), TNF-alpha (P = 0.02), testosterone (P = 0.03), and diastolic blood pressure (P = 0.01) than CTR. Conclusion:  Endothelial dysfunction, reduced insulin sensitivity and subclinical inflammation are present in otherwise healthy women with previous SGA. These abnormalities show that the presence of a SGA infant in the obstetric history should be considered as a risk factor for cardiovascular disease later in life.
Inglese
Paradisi, G., Mattoli, M. V., Tomei, C., Zuppi, C., Lulli, P., Quagliozzi, L., Caruso, A., Cardiovascular risk factors in healthy women with previous small for gestational age infants., <<THE JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH>>, 2011; (Maggio): 1397-1404 [http://hdl.handle.net/10807/12847]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/12847
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