Iatrogenic hyperstimulation of the ovary with ascites: report of a case and considerations and management

The authors describe a case of iatrogenic hyperstimulation of the ovary with ascites in a patient with primary amenorrhea and hypogonadotropic hypogonadism. They present the results of total urinary estrogen assays stressing the advisability of a technical check in the presence of an apparently abnormally high estrogen excretion during HMG therapy. The patient's biochemical and hematological data during the stage of clinical hyperstimulation are set out and management is discussed. Finally, the usefulness of timely and adequate albumin administration under CVP control is stressed and the possibility of clinical application of the result of recent experimental research (viz. antihistamines) is discussed.