Immune cells sense foreign organisms through the evolutionarily conserved family of Toll-like receptors. Signaling from these receptors relies on oligomerization of adaptor molecules. In this issue of Structure, Vynke et al. (2016) shed light on the dynamical structure of the homo- and hetero-dimerization domain of MyD88, the main adaptor utilized by Toll-like receptors.
Naro, C., Sette, C., Dissecting a Hub for Immune Response: Modeling the Structure of MyD88, <<STRUCTURE>>, 2016; 24 (3): 349-351. [doi:10.1016/j.str.2016.02.005] [http://hdl.handle.net/10807/124734]
Dissecting a Hub for Immune Response: Modeling the Structure of MyD88
Naro, Chiara;Sette, Claudio
2016
Abstract
Immune cells sense foreign organisms through the evolutionarily conserved family of Toll-like receptors. Signaling from these receptors relies on oligomerization of adaptor molecules. In this issue of Structure, Vynke et al. (2016) shed light on the dynamical structure of the homo- and hetero-dimerization domain of MyD88, the main adaptor utilized by Toll-like receptors.
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