Caveolae are 50- to 100-nm cholesterol and glycosphingolipid-rich flask-shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction.

Filippini, A., Sica, G., D'alessio, A., The caveolar membrane system in endothelium: From cell signaling to vascular pathology, <<JOURNAL OF CELLULAR BIOCHEMISTRY>>, 2018; 119 (7): 5060-5071. [doi:10.1002/jcb.26793] [http://hdl.handle.net/10807/122563]

The caveolar membrane system in endothelium: From cell signaling to vascular pathology

Sica, Gigliola
Secondo
;
D'Alessio, Alessio
Ultimo
2018

Abstract

Caveolae are 50- to 100-nm cholesterol and glycosphingolipid-rich flask-shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction.
Inglese
Filippini, A., Sica, G., D'alessio, A., The caveolar membrane system in endothelium: From cell signaling to vascular pathology, <<JOURNAL OF CELLULAR BIOCHEMISTRY>>, 2018; 119 (7): 5060-5071. [doi:10.1002/jcb.26793] [http://hdl.handle.net/10807/122563]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/122563
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