The prevalence of nonalcoholic fatty liver disease and the consequent burden of metabolic syndrome have increased in recent years. Although the pathogenesis of nonalcoholic fatty liver disease is not completely understood, it is thought to be the hepatic manifestation of the dysregulation of insulin-dependent pathways leading to insulin resistance and adipose tissue accumulation in the liver. Recently, the gut-liver axis has been proposed as a key player in the pathogenesis of NAFLD, as the passage of bacteria-derived products into the portal circulation could lead to a trigger of innate immunity, which in turn leads to liver inflammation. Additionally, higher prevalence of intestinal dysbiosis, larger production of endogenous ethanol, and higher prevalence of increased intestinal permeability and bacterial translocation were found in patients with liver injury. In this review, we describe the role of intestinal dysbiosis in the activation of the inflammatory cascade in NAFLD

Bibbo', S., Ianiro, G., Dore, M., Simonelli, C., Newton, E., Cammarota, G., Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease, <<MEDIATORS OF INFLAMMATION>>, 2018; (2018): N/A-N/A. [doi:10.1155/2018/9321643] [http://hdl.handle.net/10807/122500]

Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease

Bibbo', Stefano;Ianiro, Gianluca;Cammarota, Giovanni
Ultimo
2018

Abstract

The prevalence of nonalcoholic fatty liver disease and the consequent burden of metabolic syndrome have increased in recent years. Although the pathogenesis of nonalcoholic fatty liver disease is not completely understood, it is thought to be the hepatic manifestation of the dysregulation of insulin-dependent pathways leading to insulin resistance and adipose tissue accumulation in the liver. Recently, the gut-liver axis has been proposed as a key player in the pathogenesis of NAFLD, as the passage of bacteria-derived products into the portal circulation could lead to a trigger of innate immunity, which in turn leads to liver inflammation. Additionally, higher prevalence of intestinal dysbiosis, larger production of endogenous ethanol, and higher prevalence of increased intestinal permeability and bacterial translocation were found in patients with liver injury. In this review, we describe the role of intestinal dysbiosis in the activation of the inflammatory cascade in NAFLD
2018
Inglese
Bibbo', S., Ianiro, G., Dore, M., Simonelli, C., Newton, E., Cammarota, G., Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease, <<MEDIATORS OF INFLAMMATION>>, 2018; (2018): N/A-N/A. [doi:10.1155/2018/9321643] [http://hdl.handle.net/10807/122500]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/122500
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