The purpose of this study was to determine whether single-fiber conduction velocity (SF-CV) of a small number of axons increases sensitivity for identification of motor nerve conduction alterations in patients with diabetes. Methods: Twenty-one consecutive diabetic patients in good metabolic control were studied. For each patient, conventional (C-CV) and SF-CV results were correlated with the presence of neuropathic symptoms. Results: Nine of 21 patients reported symptoms suggestive of mild nerve impairment. Three patients had abnormal sural nerve CV, 1 of whom also had abnormal motor nerve conduction. Eighteen patients had normal findings on conventional tests, 3 of whom had slowing of SF-CV. Conclusions: SF-CV is able to detect mild myelin damage with higher sensitivity than conventional tests. The use of SF-CV may be a helpful tool in the early identification of diabetic polyneuropathy, and it may be useful for tailoring an approach to diabetic polyneuropathy.

Padua, L., Stålberg, E., Caliandro, P., Muscogiuri, G., Pazzaglia, C., Sorice, G., Granata, G., Salomone, E., Pontecorvi, A., Giaccari, A., Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes, <<MUSCLE & NERVE>>, 2011; 43 (5): 652-656. [doi:10.1002/mus.21935] [http://hdl.handle.net/10807/11928]

Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes

Padua, Luca;Caliandro, Pietro;Muscogiuri, Giovanna;Pazzaglia, Costanza;Sorice, Gianpio;Granata, Giuseppe;Salomone, Enrica;Pontecorvi, Alfredo;Giaccari, Andrea
2011

Abstract

The purpose of this study was to determine whether single-fiber conduction velocity (SF-CV) of a small number of axons increases sensitivity for identification of motor nerve conduction alterations in patients with diabetes. Methods: Twenty-one consecutive diabetic patients in good metabolic control were studied. For each patient, conventional (C-CV) and SF-CV results were correlated with the presence of neuropathic symptoms. Results: Nine of 21 patients reported symptoms suggestive of mild nerve impairment. Three patients had abnormal sural nerve CV, 1 of whom also had abnormal motor nerve conduction. Eighteen patients had normal findings on conventional tests, 3 of whom had slowing of SF-CV. Conclusions: SF-CV is able to detect mild myelin damage with higher sensitivity than conventional tests. The use of SF-CV may be a helpful tool in the early identification of diabetic polyneuropathy, and it may be useful for tailoring an approach to diabetic polyneuropathy.
Inglese
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4598
Padua, L., Stålberg, E., Caliandro, P., Muscogiuri, G., Pazzaglia, C., Sorice, G., Granata, G., Salomone, E., Pontecorvi, A., Giaccari, A., Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes, <>, 2011; 43 (5): 652-656. [doi:10.1002/mus.21935] [http://hdl.handle.net/10807/11928]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/11928
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 7
social impact