Adjunctive therapy with adenosine has been shown to improve coronary flow in patients with acute coronary syndromes (ACS); it is unclear, however, whether adenosine can effectively reduce adverse clinical events. The aim of our study was to perform a meta-analysis of all randomized controlled trials (RCTs) investigating angiographic and clinical outcomes in ACS patients undergoing PCI or thrombolysis and receiving adjunctive adenosine therapy vs. placebo.
Navarese, E., Buffon, A. M. T., Andreotti, F., Gurbel, P., Kozinski, M., Kubica, A., Musumeci, G., Cremonesi, A., Tavazzi, L., Kubica, J., Castriota, F., Adenosine improves post-procedural coronary flow but not clinical outcomes in patients with acute coronary syndrome: a meta-analysis of randomized trials, <<ATHEROSCLEROSIS>>, 2012; 222 (1): 1-7. [doi:10.1016/j.atherosclerosis.2011.11.001] [http://hdl.handle.net/10807/11615]
Adenosine improves post-procedural coronary flow but not clinical outcomes in patients with acute coronary syndrome: a meta-analysis of randomized trials
Buffon, Antonino Maria Tommaso;Andreotti, Felicita;
2012
Abstract
Adjunctive therapy with adenosine has been shown to improve coronary flow in patients with acute coronary syndromes (ACS); it is unclear, however, whether adenosine can effectively reduce adverse clinical events. The aim of our study was to perform a meta-analysis of all randomized controlled trials (RCTs) investigating angiographic and clinical outcomes in ACS patients undergoing PCI or thrombolysis and receiving adjunctive adenosine therapy vs. placebo.
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