BACKGROUND: The role of post-reperfusion lactate clearance in assessing graft function has not yet been investigated. The aim of this study was to examine whether lactate clearance, assessed in the post-reperfusion phase, can predict poor graft function in liver transplant patients. METHODS: Seventy patients undergoing liver transplantation (LT) were enrolled. Standardised anaesthesia and intraoperative monitoring were applied. The lactate level measured immediately after venous reperfusion and 6 hours later were used to calculate lactate clearance by the following formula: [(reperfusion lactate - 6h post-reperfusion lactate)/reperfusion lactate] ×100. Student's t-test was performed to evaluate differences in lactate clearance between patients with good and poor graft function. Logistic regression was used to assess predictors of poor graft function. RESULTS: Post-reperfusion lactate clearance was lower in patients with poor graft function compared to those with good graft function (p=0.0007). Logistic regression showed that post-reperfusion lactate clearance may represent an early predictor of poor graft function (area under receiver operating characteristic curve = 0.83). A lactate clearance cut-off of 59.7% was found (90% sensitivity, 38.3% specificity). CONCLUSIONS: Post-reperfusion lactate clearance may be useful for the early identification of poor graft function after LT. In patients with lactate clearance <59.7%, it could be useful to search for the underlying cause of poor graft function.

Perilli, V., Aceto, P., Sacco, T., Ciocchetti, P., Papanice, D., Lai, C., Sollazzi, L., Usefulness of post-reperfusion lactate clearance for predicting early graft recovery in liver transplant patients: a single centre study, <<MINERVA ANESTESIOLOGICA>>, 2018; 2018 (N/A): N/A-N/A. [doi:10.23736/S0375-9393.18.12285-1] [http://hdl.handle.net/10807/115352]

Usefulness of post-reperfusion lactate clearance for predicting early graft recovery in liver transplant patients: a single centre study

Perilli, Valter;Aceto, Paola;Sacco, Teresa;Ciocchetti, Pierpaolo;Papanice, Domenico;Lai, Carlo;Sollazzi, Liliana
2018

Abstract

BACKGROUND: The role of post-reperfusion lactate clearance in assessing graft function has not yet been investigated. The aim of this study was to examine whether lactate clearance, assessed in the post-reperfusion phase, can predict poor graft function in liver transplant patients. METHODS: Seventy patients undergoing liver transplantation (LT) were enrolled. Standardised anaesthesia and intraoperative monitoring were applied. The lactate level measured immediately after venous reperfusion and 6 hours later were used to calculate lactate clearance by the following formula: [(reperfusion lactate - 6h post-reperfusion lactate)/reperfusion lactate] ×100. Student's t-test was performed to evaluate differences in lactate clearance between patients with good and poor graft function. Logistic regression was used to assess predictors of poor graft function. RESULTS: Post-reperfusion lactate clearance was lower in patients with poor graft function compared to those with good graft function (p=0.0007). Logistic regression showed that post-reperfusion lactate clearance may represent an early predictor of poor graft function (area under receiver operating characteristic curve = 0.83). A lactate clearance cut-off of 59.7% was found (90% sensitivity, 38.3% specificity). CONCLUSIONS: Post-reperfusion lactate clearance may be useful for the early identification of poor graft function after LT. In patients with lactate clearance <59.7%, it could be useful to search for the underlying cause of poor graft function.
2018
Inglese
Perilli, V., Aceto, P., Sacco, T., Ciocchetti, P., Papanice, D., Lai, C., Sollazzi, L., Usefulness of post-reperfusion lactate clearance for predicting early graft recovery in liver transplant patients: a single centre study, <<MINERVA ANESTESIOLOGICA>>, 2018; 2018 (N/A): N/A-N/A. [doi:10.23736/S0375-9393.18.12285-1] [http://hdl.handle.net/10807/115352]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/115352
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