MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
Alivernini, S., Gremese, E., Mcsharry, C., Tolusso, B., Ferraccioli, G., Mcinnes Iain, B., Kurowska-Stolarska, M., MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis., <<FRONTIERS IN IMMUNOLOGY>>, 2018; (Jan): 1932-N/A. [doi:10.3389/fimmu.2017.01932] [http://hdl.handle.net/10807/114714]
MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
Alivernini, Stefano;Gremese, Elisa;Tolusso, Barbara;Ferraccioli, Gianfranco;
2018
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
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