Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis. These morphological findings suggested that autoreactive T-cell clones were responsible for thyrocyte destruction and hypothyroidism through effector-target cytotoxic recognition. Later, autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto's thyroiditis. Here, we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto's thyroiditis. We suggest that the Fas-FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells.

Stassi, G., Zeuner, A., Di Liberto, D., Todaro, M., Ricci-Vitiani, L., De Maria, R., Fas-FasL in Hashimoto's thyroiditis, <<JOURNAL OF CLINICAL IMMUNOLOGY>>, 2001; 21 (1): 19-23. [doi:10.1023/A:1006732713634] [http://hdl.handle.net/10807/113868]

Fas-FasL in Hashimoto's thyroiditis

De Maria, R
2001

Abstract

Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis. These morphological findings suggested that autoreactive T-cell clones were responsible for thyrocyte destruction and hypothyroidism through effector-target cytotoxic recognition. Later, autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto's thyroiditis. Here, we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto's thyroiditis. We suggest that the Fas-FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells.
Inglese
Stassi, G., Zeuner, A., Di Liberto, D., Todaro, M., Ricci-Vitiani, L., De Maria, R., Fas-FasL in Hashimoto's thyroiditis, <<JOURNAL OF CLINICAL IMMUNOLOGY>>, 2001; 21 (1): 19-23. [doi:10.1023/A:1006732713634] [http://hdl.handle.net/10807/113868]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/113868
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