Many studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer's disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD in the blood, a gradually increasing attention has been given to the study of RBC's alterations. Recently it has been evidenced in diabetes, RBC alterations superimposable to the ones occurring in AD RBC. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of RBC's alterations and vice versa. Once again this represents a further evidence of a shared pathway between AD and T2DM. The present review summarizes the two disorders, highlighting the role of RBC in the postulated common biochemical links, and suggests RBC as a possible target for clinical trials.

Carelli-alinovi, C., Misiti, F., Erythrocytes as potential link between diabetes and Alzheimer's disease, <<FRONTIERS IN AGING NEUROSCIENCE>>, 2017; 9 (276): N/A-N/A. [doi:10.3389/fnagi.2017.00276] [http://hdl.handle.net/10807/113473]

Erythrocytes as potential link between diabetes and Alzheimer's disease

Carelli-Alinovi, Cristiana
Primo
;
Misiti, Francesco
Ultimo
2017

Abstract

Many studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer's disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD in the blood, a gradually increasing attention has been given to the study of RBC's alterations. Recently it has been evidenced in diabetes, RBC alterations superimposable to the ones occurring in AD RBC. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of RBC's alterations and vice versa. Once again this represents a further evidence of a shared pathway between AD and T2DM. The present review summarizes the two disorders, highlighting the role of RBC in the postulated common biochemical links, and suggests RBC as a possible target for clinical trials.
Inglese
Carelli-alinovi, C., Misiti, F., Erythrocytes as potential link between diabetes and Alzheimer's disease, <<FRONTIERS IN AGING NEUROSCIENCE>>, 2017; 9 (276): N/A-N/A. [doi:10.3389/fnagi.2017.00276] [http://hdl.handle.net/10807/113473]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/113473
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 12
social impact