Background: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer’s cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. Methods: We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy. Results: All stages of liver fibrosis were represented in our cohort, and severe fibrosis was present in 15 of 82 patients (18.3%). The stage of fibrosis was significantly associated with ELF score (Spearman’s rho = 0.483, p<0.001). The commercial ELF test manufacturer’s cutoff identified severe fibrosis with good sensitivity (86.7%; 95% confidence interval [95% CI], 0.69-1.04) and high specificity (92.5%; 95% CI, 0.86-0.99), with a positive predictive value of 72% and negative predictive value of 97%. Conclusions: Our data could support the use of the ELF test in clinical practice.

Miele, L., De Michele, T., Marrone, G., Antonietta Isgrò, M., Basile, U., Cefalo, C., Biolato, M., Maria Vecchio, F., Lodovico Rapaccini, G., Gasbarrini, A., Zuppi, C., Grieco, A., Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting, <<THE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS>>, 2017; 32 (4): N/A-N/A. [doi:10.5301/ijbm.5000292] [http://hdl.handle.net/10807/113183]

Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting

Miele, Luca;De Michele, Teresa;Marrone, Giuseppe;Antonietta Isgrò, Maria;Basile, Umberto;Cefalo, Consuelo;Biolato, Marco;Maria Vecchio, Fabio;Gasbarrini, Antonio;Zuppi, Cecilia;Grieco, Antonio
2017

Abstract

Background: Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer’s cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. Methods: We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy. Results: All stages of liver fibrosis were represented in our cohort, and severe fibrosis was present in 15 of 82 patients (18.3%). The stage of fibrosis was significantly associated with ELF score (Spearman’s rho = 0.483, p<0.001). The commercial ELF test manufacturer’s cutoff identified severe fibrosis with good sensitivity (86.7%; 95% confidence interval [95% CI], 0.69-1.04) and high specificity (92.5%; 95% CI, 0.86-0.99), with a positive predictive value of 72% and negative predictive value of 97%. Conclusions: Our data could support the use of the ELF test in clinical practice.
eng
http://www.biological-markers.com/Attach/9239e1b0-c452-4fe6-b3aa-0b97eb246c21/470c1100-6af3-4dc2-99a5-5ad4b3445845
Miele, L., De Michele, T., Marrone, G., Antonietta Isgrò, M., Basile, U., Cefalo, C., Biolato, M., Maria Vecchio, F., Lodovico Rapaccini, G., Gasbarrini, A., Zuppi, C., Grieco, A., Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting, <>, 2017; 32 (4): N/A-N/A. [doi:10.5301/ijbm.5000292] [http://hdl.handle.net/10807/113183]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/113183
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 11
social impact