Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNAderegulation in prostate cancer disease, underlining present limits and future perspectives. © 2010 Society for Endocrinology.
Coppola, V., De Maria Marchiano, R., Bonci, D., MicroRNAs and prostate cancer, <<ENDOCRINE-RELATED CANCER>>, 2010; 17 (1): 1-17. [doi:10.1677/ERC-09-0172] [http://hdl.handle.net/10807/112832]
MicroRNAs and prostate cancer
Coppola, Valeria;De Maria Marchiano, Ruggero;
2010
Abstract
Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNAderegulation in prostate cancer disease, underlining present limits and future perspectives. © 2010 Society for Endocrinology.
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