Despite therapeutic advances, glioblastoma multiforme (GBM) remains a lethal disease. The infiltrative nature of this disease and the presence of a cellular population resistant to current medical treatments account for the poor prognosis of these patients. Growing evidence indicates the existence of a fraction of cancer cells sharing the functional properties of adult stem cells, including self-renewal and a greater ability to escape chemo-radiotherapy-induced death stimuli. Therefore, these cells are commonly defined as cancer stem cells (GBM-SCs). The initial GBM-SC concept has been challenged, and refined according to the emerging molecular taxonomy of GBM. This allowed to postulate the existence of multiple CSC types, each one driving a given molecular entity. Furthermore, it is becoming increasingly clear that GBM-SCs thrive through a dynamic and bidirectional interaction with the surrounding microenvironment. In this article, we discuss recent advances in GBM-SC biology, mechanisms through which these cells adapt to hostile conditions, pharmacological strategies for selectively killing GBM-SCs, and how novel CSC-associated endpoints have been investigated in the clinical setting.©2013 Maugeri-Saccà, Di Martino and De Maria.

Maugeri-Saccà, M., Di Martino, S., De Maria Marchiano, R., Biological and clinical implications of cancer stem cells in primary brain tumors, <<FRONTIERS IN ONCOLOGY>>, 2014; 3 (N/A): N/A-N/A. [doi:10.3389/fonc.2013.00006] [http://hdl.handle.net/10807/112115]

Biological and clinical implications of cancer stem cells in primary brain tumors

De Maria Marchiano, Ruggero
2013

Abstract

Despite therapeutic advances, glioblastoma multiforme (GBM) remains a lethal disease. The infiltrative nature of this disease and the presence of a cellular population resistant to current medical treatments account for the poor prognosis of these patients. Growing evidence indicates the existence of a fraction of cancer cells sharing the functional properties of adult stem cells, including self-renewal and a greater ability to escape chemo-radiotherapy-induced death stimuli. Therefore, these cells are commonly defined as cancer stem cells (GBM-SCs). The initial GBM-SC concept has been challenged, and refined according to the emerging molecular taxonomy of GBM. This allowed to postulate the existence of multiple CSC types, each one driving a given molecular entity. Furthermore, it is becoming increasingly clear that GBM-SCs thrive through a dynamic and bidirectional interaction with the surrounding microenvironment. In this article, we discuss recent advances in GBM-SC biology, mechanisms through which these cells adapt to hostile conditions, pharmacological strategies for selectively killing GBM-SCs, and how novel CSC-associated endpoints have been investigated in the clinical setting.©2013 Maugeri-Saccà, Di Martino and De Maria.
Inglese
Maugeri-Saccà, M., Di Martino, S., De Maria Marchiano, R., Biological and clinical implications of cancer stem cells in primary brain tumors, <<FRONTIERS IN ONCOLOGY>>, 2014; 3 (N/A): N/A-N/A. [doi:10.3389/fonc.2013.00006] [http://hdl.handle.net/10807/112115]
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