If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome. Originally described as potent antivirals, Type-I interferons (IFNs) were quickly recognized as central coordinators of tumor-immune system interactions. Type-I-IFNs are produced by, and act on, both tumor and immune cells being either host-protecting or tumor-promoting. Here, we discuss Type-I-IFNs in infectious and cancer diseases highlighting their dichotomous role and raising the importance to deeply understand the underlying mechanisms so to reshape the way we can exploit Type-I-IFNs therapeutically.
Musella, M., Manic, G., De Maria Marchiano, R., Vitale, I., Sistigu, A., Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications, <<ONCOIMMUNOLOGY>>, 2017; 6 (5): N/A-N/A. [doi:10.1080/2162402X.2017.1314424] [http://hdl.handle.net/10807/111917]
Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications
De Maria Marchiano, Ruggero;Vitale, Ilio;Sistigu, Antonella
2017
Abstract
If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome. Originally described as potent antivirals, Type-I interferons (IFNs) were quickly recognized as central coordinators of tumor-immune system interactions. Type-I-IFNs are produced by, and act on, both tumor and immune cells being either host-protecting or tumor-promoting. Here, we discuss Type-I-IFNs in infectious and cancer diseases highlighting their dichotomous role and raising the importance to deeply understand the underlying mechanisms so to reshape the way we can exploit Type-I-IFNs therapeutically.File | Dimensione | Formato | |
---|---|---|---|
Type I interferons.pdf
Open Access dal 01/05/2018
Tipologia file ?:
Postprint (versione finale dell’autore successiva alla peer-review)
Licenza:
Creative commons
Dimensione
3.75 MB
Formato
Adobe PDF
|
3.75 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.