Overcoming resistance to standard anticancer treatments represents a signi cant challenge. The interest regarding cancer stem cells, a cellular population that has the ability to self-renew and to propagate the tumor, was prompted by experimental evidence delineating the molecular mechanisms that are selectively activated in this cellular subset in order to survive chemotherapy. This has also stimulated combination strategies aimed at rendering cancer stem cells vulnerable to anticancer agents. Moreover, cancer stem cells o er a unique opportunity for modeling human cancers in mice, thus emerging as a powerful tool for testing novel drugs and combinations in a simulation of human disease. These novel animal models may lay the foundation for a new generation of clinical trials aimed at anticipating the bene t to patients of anticancer therapies.

Marcello, M., Patrizia, V., Luigi Di, L., Maddalena, B., Carla Azzurra, A., Enzo, G., Marcella, M., De Maria Marchiano, R., Cancer stem cells: are they responsible for treatment failure?, <<FUTURE ONCOLOGY>>, 2014; (10 (13)): 2033-2044. [doi:10.2217/FON.14.126] [http://hdl.handle.net/10807/111343]

Cancer stem cells: are they responsible for treatment failure?

De Maria Marchiano, Ruggero.
2014

Abstract

Overcoming resistance to standard anticancer treatments represents a signi cant challenge. The interest regarding cancer stem cells, a cellular population that has the ability to self-renew and to propagate the tumor, was prompted by experimental evidence delineating the molecular mechanisms that are selectively activated in this cellular subset in order to survive chemotherapy. This has also stimulated combination strategies aimed at rendering cancer stem cells vulnerable to anticancer agents. Moreover, cancer stem cells o er a unique opportunity for modeling human cancers in mice, thus emerging as a powerful tool for testing novel drugs and combinations in a simulation of human disease. These novel animal models may lay the foundation for a new generation of clinical trials aimed at anticipating the bene t to patients of anticancer therapies.
Inglese
Marcello, M., Patrizia, V., Luigi Di, L., Maddalena, B., Carla Azzurra, A., Enzo, G., Marcella, M., De Maria Marchiano, R., Cancer stem cells: are they responsible for treatment failure?, <<FUTURE ONCOLOGY>>, 2014; (10 (13)): 2033-2044. [doi:10.2217/FON.14.126] [http://hdl.handle.net/10807/111343]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/111343
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