Cathespin D (Cath D) is a proteolytic enzyme secreted by human breast cancer cells with a growth promoting activity in vitro. In the present study, we measured Cath D and Epidermal Growth Factor/alpha Transforming Growth Factor (EGF/alpha-TGF) concentrations in the breast cyst fluid (BCF) of 43 patients with gross cystic disease of the breast. Both Cath D (median 2.45 pmoles mg-1 protein; range 0-4.84 vs 0.98 pmoles mg-1 protein; range 0-3.11) and EGF/alpha-TGF (28.71 ng mg-1 protein; range 7.05-50.63 vs 10.83 ng mg-1 protein; range 0.06-30.55) levels were higher in BCF of apocrine than flattened cysts (P less than 0.0005 and P less than 0.01, respectively). Premenopausal patients showed higher concentrations of Cath D (P less than 0.05) and EGF/alpha-TGF (P less than 0.05) than postmenopausal patients. A positive correlation was obtained between intracystic concentrations of Cath D and EGF/alpha-TGF (P less than 0.00001). The higher levels of Cath-D and EGF/alpha-TGF found in apocrine cysts could provide an explanation for the increased risk of subsequent breast cancer in women with this type of cyst.

Scambia, G., Benedetti Panici, P., Ferrandina, G., Battaglia, F., Rossi, S., Bellantone, R. D. A., Crucitti, F., Mancuso, S., Cathepsin D and epidermal growth factor in human breast cyst fluid, <<BRITISH JOURNAL OF CANCER>>, 1991; 64 (5): 965-967 [http://hdl.handle.net/10807/11128]

Cathepsin D and epidermal growth factor in human breast cyst fluid

Scambia, Giovanni;Rossi, Sabrina;Bellantone, Rocco Domenico Alfonso;Mancuso, Salvatore
1991

Abstract

Cathespin D (Cath D) is a proteolytic enzyme secreted by human breast cancer cells with a growth promoting activity in vitro. In the present study, we measured Cath D and Epidermal Growth Factor/alpha Transforming Growth Factor (EGF/alpha-TGF) concentrations in the breast cyst fluid (BCF) of 43 patients with gross cystic disease of the breast. Both Cath D (median 2.45 pmoles mg-1 protein; range 0-4.84 vs 0.98 pmoles mg-1 protein; range 0-3.11) and EGF/alpha-TGF (28.71 ng mg-1 protein; range 7.05-50.63 vs 10.83 ng mg-1 protein; range 0.06-30.55) levels were higher in BCF of apocrine than flattened cysts (P less than 0.0005 and P less than 0.01, respectively). Premenopausal patients showed higher concentrations of Cath D (P less than 0.05) and EGF/alpha-TGF (P less than 0.05) than postmenopausal patients. A positive correlation was obtained between intracystic concentrations of Cath D and EGF/alpha-TGF (P less than 0.00001). The higher levels of Cath-D and EGF/alpha-TGF found in apocrine cysts could provide an explanation for the increased risk of subsequent breast cancer in women with this type of cyst.
Inglese
Scambia, G., Benedetti Panici, P., Ferrandina, G., Battaglia, F., Rossi, S., Bellantone, R. D. A., Crucitti, F., Mancuso, S., Cathepsin D and epidermal growth factor in human breast cyst fluid, <>, 1991; 64 (5): 965-967 [http://hdl.handle.net/10807/11128]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/11128
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