Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to of the continued development of the field.

Galluzzi, L., Vitale, I., Aaronson, S., Abrams, J., Adam, D., Agostinis, P., Alnemri, E., Altucci, L., Amelio, I., Andrews, D., Annicchiarico-Petruzzelli, M., Antonov, A., Arama, E., Baehrecke, E., Barlev, N., Bazan, N., Bernassola, F., Bertrand, M., Bianchi, K., Blagosklonny, M., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F., Chandel, N., Cheng, E., Chipuk, J., Cidlowski, J., Ciechanover, A., Cohen, G., Conrad, M., Cubillos-Ruiz, J., Czabotar, P., D'Angiolella, V., Dawson, T., Dawson, V., De Laurenzi, V., De Maria Marchiano, R., Debatin, K., Deberardinis, R., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V., Dixon, S., Duckett, C., Dynlacht, B., El-Deiry, W., Elrod, J., Fimia, G., Fulda, S., García-Sáez, A., Garg, A., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D., Greene, L., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J., Harris, I., Hengartner, M., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P., Juin, P., Kaiser, W., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R., Klionsky, D., Knight, R., Kumar, S., Lee, S., Lemasters, J., Levine, B., Linkermann, A., Lipton, S., Lockshin, R., López-Otín, C., Lowe, S., Luedde, T., Lugli, E., Macfarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J., Martin, S., Martinou, J., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E., Molkentin, J., Moll, U., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J., Pereira, D., Pervaiz, S., Peter, M., Piacentini, M., Calzavara Pinton, P., Prehn, J., Puthalakath, H., Rabinovich, G., Rehm, M., Rizzuto, R., Rodrigues, C., Rubinsztein, D., Rudel, T., Ryan, K., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H., Sistigu, A., Stockwell, B., Strasser, A., Szabadkai, G., Tait, S., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M., Villunger, A., Virgin, H., Vousden, K., Vucic, D., Wagner, E., Walczak, H., Wallach, D., Wang, Y., Wells, J., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G., Kroemer, G., Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, <<CELL DEATH AND DIFFERENTIATION>>, 2018; 25 (3): 486-541. [doi:10.1038/s41418-017-0012-4] [http://hdl.handle.net/10807/111216]

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

De Maria Marchiano, Ruggero;Medema, Jan Paul;Pagano, Marco;Calzavara Pinton, Piergiacomo;Sistigu, Antonella;
2018

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to of the continued development of the field.
2018
Inglese
Galluzzi, L., Vitale, I., Aaronson, S., Abrams, J., Adam, D., Agostinis, P., Alnemri, E., Altucci, L., Amelio, I., Andrews, D., Annicchiarico-Petruzzelli, M., Antonov, A., Arama, E., Baehrecke, E., Barlev, N., Bazan, N., Bernassola, F., Bertrand, M., Bianchi, K., Blagosklonny, M., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F., Chandel, N., Cheng, E., Chipuk, J., Cidlowski, J., Ciechanover, A., Cohen, G., Conrad, M., Cubillos-Ruiz, J., Czabotar, P., D'Angiolella, V., Dawson, T., Dawson, V., De Laurenzi, V., De Maria Marchiano, R., Debatin, K., Deberardinis, R., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V., Dixon, S., Duckett, C., Dynlacht, B., El-Deiry, W., Elrod, J., Fimia, G., Fulda, S., García-Sáez, A., Garg, A., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D., Greene, L., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J., Harris, I., Hengartner, M., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P., Juin, P., Kaiser, W., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R., Klionsky, D., Knight, R., Kumar, S., Lee, S., Lemasters, J., Levine, B., Linkermann, A., Lipton, S., Lockshin, R., López-Otín, C., Lowe, S., Luedde, T., Lugli, E., Macfarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J., Martin, S., Martinou, J., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E., Molkentin, J., Moll, U., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J., Pereira, D., Pervaiz, S., Peter, M., Piacentini, M., Calzavara Pinton, P., Prehn, J., Puthalakath, H., Rabinovich, G., Rehm, M., Rizzuto, R., Rodrigues, C., Rubinsztein, D., Rudel, T., Ryan, K., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H., Sistigu, A., Stockwell, B., Strasser, A., Szabadkai, G., Tait, S., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M., Villunger, A., Virgin, H., Vousden, K., Vucic, D., Wagner, E., Walczak, H., Wallach, D., Wang, Y., Wells, J., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G., Kroemer, G., Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, <<CELL DEATH AND DIFFERENTIATION>>, 2018; 25 (3): 486-541. [doi:10.1038/s41418-017-0012-4] [http://hdl.handle.net/10807/111216]
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