BACKGROUND: there are many contradictions about pregnancy and fetal/neonatal outcomes after topical use of timolol alone or timolol in combination with other antiglaucoma medications. METHOD: Seventy-five pregnant women exposed to antiglaucoma medications were followed prospectively by phone interviews. 27 women used timolol as monotherapy, 48 women used timolol as part of multidrug therapy. We selected a control group of 187 healthy pregnant women. RESULTS: topical use of timolol alone or timolol in combination with other antiglaucoma medications don't influence pregnancy or fetal/neonatal outcomes. CONCLUSION: beta-blocker is the first choice treatment for glaucoma in pregnancy but, when necessary, multidrug therapy should not to be excluded.
Pellegrino, M., D'Oria, L., De Luca, C., Chiaradia, G., Licameli, A., Neri, C., Nucci, M., Visconti, D., Caruso, A., De Santis, M., Glaucoma drug therapy in pregnancy: literature review and Teratology Information Service (TIS) case series, <<CURRENT DRUG SAFETY>>, 2017; 13 (1): 3-11. [doi:10.2174/1574886312666171030125804] [http://hdl.handle.net/10807/110716]
Glaucoma drug therapy in pregnancy: literature review and Teratology Information Service (TIS) case series
Pellegrino, Marcella;D'Oria, Luisa;De Luca, Carmen;Chiaradia, Giacomina;Licameli, Angelo;Neri, Caterina;Nucci, Marta;Visconti, Daniela;Caruso, Alessandro;De Santis, Marco
2018
Abstract
BACKGROUND: there are many contradictions about pregnancy and fetal/neonatal outcomes after topical use of timolol alone or timolol in combination with other antiglaucoma medications. METHOD: Seventy-five pregnant women exposed to antiglaucoma medications were followed prospectively by phone interviews. 27 women used timolol as monotherapy, 48 women used timolol as part of multidrug therapy. We selected a control group of 187 healthy pregnant women. RESULTS: topical use of timolol alone or timolol in combination with other antiglaucoma medications don't influence pregnancy or fetal/neonatal outcomes. CONCLUSION: beta-blocker is the first choice treatment for glaucoma in pregnancy but, when necessary, multidrug therapy should not to be excluded.
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