Epidermal growth factor (EGF-R) estrogen (ER) and progesterone (PR) receptors were evaluated in 89 primary breast cancers and 23 axillary lymph node metastases. About 57% of primary and 72.2% of metastatic tumors were EGF-R positive and median EGF-R levels were higher in metastatic deposits than in primary breast tumors (P less than 0.05). An inverse distribution of EGF-R and steroid hormone receptor positive tumors was found (chi 2 = 10.87; P less than 0.001 for PR and chi 2 = 5.01; P less than 0.05 for ER) and an interesting correlation between EGF-R expression in primary tumor and axillary lymph node involvement was demonstrated (chi 2 = 21.4; P less than 0.001). Immunohistochemical studies with a monoclonal antibody against EGF-R revealed the presence of EGF-R only in malignant cells. Our data suggest that EGF-R could identify a class of more aggressive breast tumors endowed with a higher metastatic potential and may therefore represent an unfavorable prognostic parameter in breast cancer.

Battaglia, F., Scambia, G., Rossi, S., Panici, P., Bellantone, R. D. A., Polizzi, G., Querzoli, P., Negrini, R., Iacobelli, S., Crucitti, F., Epidermal growth factor receptor in human breast cancer: correlation with steroid hormone receptors and axillary lymph node involvement, <<EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY>>, 1988; 24 (11): 1685-1690 [http://hdl.handle.net/10807/11069]

Epidermal growth factor receptor in human breast cancer: correlation with steroid hormone receptors and axillary lymph node involvement

Scambia, Giovanni;Rossi, Sabrina;Bellantone, Rocco Domenico Alfonso;
1988

Abstract

Epidermal growth factor (EGF-R) estrogen (ER) and progesterone (PR) receptors were evaluated in 89 primary breast cancers and 23 axillary lymph node metastases. About 57% of primary and 72.2% of metastatic tumors were EGF-R positive and median EGF-R levels were higher in metastatic deposits than in primary breast tumors (P less than 0.05). An inverse distribution of EGF-R and steroid hormone receptor positive tumors was found (chi 2 = 10.87; P less than 0.001 for PR and chi 2 = 5.01; P less than 0.05 for ER) and an interesting correlation between EGF-R expression in primary tumor and axillary lymph node involvement was demonstrated (chi 2 = 21.4; P less than 0.001). Immunohistochemical studies with a monoclonal antibody against EGF-R revealed the presence of EGF-R only in malignant cells. Our data suggest that EGF-R could identify a class of more aggressive breast tumors endowed with a higher metastatic potential and may therefore represent an unfavorable prognostic parameter in breast cancer.
Inglese
Battaglia, F., Scambia, G., Rossi, S., Panici, P., Bellantone, R. D. A., Polizzi, G., Querzoli, P., Negrini, R., Iacobelli, S., Crucitti, F., Epidermal growth factor receptor in human breast cancer: correlation with steroid hormone receptors and axillary lymph node involvement, <>, 1988; 24 (11): 1685-1690 [http://hdl.handle.net/10807/11069]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/11069
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