It has been demonstrated that omega‰-3 polyunsaturated fatty acids (omega-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of omega-3 PUFA in different kinds of cancers, and several human studies have shown that omega-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. omega‰-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of omega-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of omega‰-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered.

Serini, S., Vasconcelos, R. O., Gomes, R. N., Calviello, G., Protective effects of omega -3 PUFA in anthracycline-induced cardiotoxicity: A critical review, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2017; 18 (12): 2689-N/A. [doi:10.3390/ijms18122689] [http://hdl.handle.net/10807/110012]

Protective effects of omega‰-3 PUFA in anthracycline-induced cardiotoxicity: A critical review

Serini, Simona
Primo
;
Calviello, Gabriella
Ultimo
2017

Abstract

It has been demonstrated that omega‰-3 polyunsaturated fatty acids (omega-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of omega-3 PUFA in different kinds of cancers, and several human studies have shown that omega-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. omega‰-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of omega-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of omega‰-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered.
Inglese
http://www.mdpi.com/1422-0067/18/12/2689/pdf
Serini, S., Vasconcelos, R. O., Gomes, R. N., Calviello, G., Protective effects of omega -3 PUFA in anthracycline-induced cardiotoxicity: A critical review, <>, 2017; 18 (12): 2689-N/A. [doi:10.3390/ijms18122689] [http://hdl.handle.net/10807/110012]
File in questo prodotto:
File Dimensione Formato  
Serini et al., IJMS 2017.pdf

accesso aperto

Tipologia file ?: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 1.15 MB
Formato Adobe PDF
1.15 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/110012
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 19
social impact