We propose a response-adaptive design, described in terms of urn model, whose allocation proportion converges to prespecified values. The main asymptotic results concerning the urn designs are presented and discussed. We adopt the urn model to implement the random allocation procedure of an experiment that aims at testing the mean effect of two treatments. We conduct a statistical analysis on the inferential performance of different tests and we show that, given a non adaptive test T0, the response adaptive model constructs a test T that is better than T0, in terms of (a) higher power and (b) fewer subjects assigned to the inferior treatment. A retrospective real case study is presented.

Ghiglietti, A., Maria Paganoni, A., Statistical properties of urn designs in clinical trials, Contributed paper, in Proceedings of XLVII Scientific meeting of the Italian Statistical Society, (Cagliari, 11-13 June 2014), CUEC editrice, Cagliari 2014: 1-8 [http://hdl.handle.net/10807/109501]

Statistical properties of urn designs in clinical trials

Ghiglietti, Andrea;
2014

Abstract

We propose a response-adaptive design, described in terms of urn model, whose allocation proportion converges to prespecified values. The main asymptotic results concerning the urn designs are presented and discussed. We adopt the urn model to implement the random allocation procedure of an experiment that aims at testing the mean effect of two treatments. We conduct a statistical analysis on the inferential performance of different tests and we show that, given a non adaptive test T0, the response adaptive model constructs a test T that is better than T0, in terms of (a) higher power and (b) fewer subjects assigned to the inferior treatment. A retrospective real case study is presented.
Inglese
Proceedings of XLVII Scientific meeting of the Italian Statistical Society
XLVII Scientific meeting of the Italian Statistical Society
Cagliari
Contributed paper
11-giu-2014
13-giu-2014
9788884678744
CUEC editrice
Ghiglietti, A., Maria Paganoni, A., Statistical properties of urn designs in clinical trials, Contributed paper, in Proceedings of XLVII Scientific meeting of the Italian Statistical Society, (Cagliari, 11-13 June 2014), CUEC editrice, Cagliari 2014: 1-8 [http://hdl.handle.net/10807/109501]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/109501
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