Six Y-linked tetranucleotide microsatellites were typed in a sample of continental Italians and Sardinians. Significant differences in allele distributions were found between peninsular Italy and the island. Patterns of distinct allelic associations were evident in Sardinia and in the mainland. STR haplotypes in a subset of Sardinian chromosomes were monophyletically related and indicated that additions/deletions of a single tetranucleotide unit had to sequentially occur within a historical time-scale (about 9,000 years). Assumptions on both the time elapsed since the peopling of the island and the number of mutational events led us to estimate (by three different methods) a rate of 2.7-11 x 10(-4) mutations per generation per locus--at the upper end of the range of values reported in the literature.

Caglià, A., Novelletto, A., Dobosz, M., Malaspina, P., Ciminelli, B. M., Pascali, V. L., Y-chromosome STR loci in Sardinia and continental Italy reveal islander-specific haplotypes, <<EUROPEAN JOURNAL OF HUMAN GENETICS>>, 1997; 5 (5): 288-292 [http://hdl.handle.net/10807/10887]

Y-chromosome STR loci in Sardinia and continental Italy reveal islander-specific haplotypes

Dobosz, Marina;Pascali, Vincenzo Lorenzo
1997

Abstract

Six Y-linked tetranucleotide microsatellites were typed in a sample of continental Italians and Sardinians. Significant differences in allele distributions were found between peninsular Italy and the island. Patterns of distinct allelic associations were evident in Sardinia and in the mainland. STR haplotypes in a subset of Sardinian chromosomes were monophyletically related and indicated that additions/deletions of a single tetranucleotide unit had to sequentially occur within a historical time-scale (about 9,000 years). Assumptions on both the time elapsed since the peopling of the island and the number of mutational events led us to estimate (by three different methods) a rate of 2.7-11 x 10(-4) mutations per generation per locus--at the upper end of the range of values reported in the literature.
1997
Inglese
Caglià, A., Novelletto, A., Dobosz, M., Malaspina, P., Ciminelli, B. M., Pascali, V. L., Y-chromosome STR loci in Sardinia and continental Italy reveal islander-specific haplotypes, <<EUROPEAN JOURNAL OF HUMAN GENETICS>>, 1997; 5 (5): 288-292 [http://hdl.handle.net/10807/10887]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/10887
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