The clinical use of antineoplastic drugs can be limited by different drug-induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manifested as a reduction of the glomerular filtration rate, electrolyte imbalances, or acute renal failure. Careful assessment of renal function has to be performed taking into account that the impairment of renal function is initially silent and only later may be clinically dramatic. When clinically indicated, the reduction or, in cases of severe nephrotoxicity, the suspension of chemotherapy should be considered to avoid the progressive deterioration of the compromised glomerular and/or tubular function.

Ruggiero, A., Ferrara, P., Attinà, G., Rizzo, D., Riccardi, R., Renal toxicity and chemotherapy in children with cancer, <<BRITISH JOURNAL OF CLINICAL PHARMACOLOGY>>, 2017; 83 (12): 2605-2614. [doi:10.1111/bcp.13388] [http://hdl.handle.net/10807/105729]

Renal toxicity and chemotherapy in children with cancer

Ruggiero, Antonio;Ferrara, Pietro;Attinà, Giorgio;Rizzo, Daniela;Riccardi, Riccardo.
2017

Abstract

The clinical use of antineoplastic drugs can be limited by different drug-induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manifested as a reduction of the glomerular filtration rate, electrolyte imbalances, or acute renal failure. Careful assessment of renal function has to be performed taking into account that the impairment of renal function is initially silent and only later may be clinically dramatic. When clinically indicated, the reduction or, in cases of severe nephrotoxicity, the suspension of chemotherapy should be considered to avoid the progressive deterioration of the compromised glomerular and/or tubular function.
Inglese
Ruggiero, A., Ferrara, P., Attinà, G., Rizzo, D., Riccardi, R., Renal toxicity and chemotherapy in children with cancer, <<BRITISH JOURNAL OF CLINICAL PHARMACOLOGY>>, 2017; 83 (12): 2605-2614. [doi:10.1111/bcp.13388] [http://hdl.handle.net/10807/105729]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/105729
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