Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
Cauda, R., Ortona, L., Lucia, M. B. P., Rainaldi, G., Donelli, G., Malorni, W., A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients, <<IMMUNOLOGY LETTERS>>, 2000; (60): 19-21 [http://hdl.handle.net/10807/10318]
A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients
Cauda, Roberto;Ortona, Luigi;Lucia, Mothanje Barbara Patricia;
2000
Abstract
Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
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