The organ-specific modulation by ascorbic acid and related compounds on alkaline phosphatase activity of calf intestinal and human placental tissues has been studied at pH 8.0 and 37 degrees C. L(+)-ascorbic acid and its isomer D(-)-ascorbic acid inhibit to a similar extent the intestinal isoenzyme and appear to be more potent modifiers than dehydro-L-(+)-ascorbic acid. In contrast, the placental isoenzyme shows an initial activation by the three chemical agents, followed by an inhibition. The inhibition is lower with L(+)-ascorbic acid and D(-)-ascorbic acid, while its catalytic activity is affected only slightly by dehydro-L-(+)ascorbic acid.
Miggiano, G., Mordente, A., Martorana, G., Meucci, E., Castelli, A., Modulation of alkaline phosphatase in different organs by ascorbic acid and related compounds, <<ACTA VITAMINOLOGICA ET ENZYMOLOGICA>>, 1983; 5 (4): 219-224 [http://hdl.handle.net/10807/10005]
Autori: | |
Titolo: | Modulation of alkaline phosphatase in different organs by ascorbic acid and related compounds |
Data di pubblicazione: | 1983 |
Abstract: | The organ-specific modulation by ascorbic acid and related compounds on alkaline phosphatase activity of calf intestinal and human placental tissues has been studied at pH 8.0 and 37 degrees C. L(+)-ascorbic acid and its isomer D(-)-ascorbic acid inhibit to a similar extent the intestinal isoenzyme and appear to be more potent modifiers than dehydro-L-(+)-ascorbic acid. In contrast, the placental isoenzyme shows an initial activation by the three chemical agents, followed by an inhibition. The inhibition is lower with L(+)-ascorbic acid and D(-)-ascorbic acid, while its catalytic activity is affected only slightly by dehydro-L-(+)ascorbic acid. |
Lingua: | Inglese |
Rivista: | |
Citazione: | Miggiano, G., Mordente, A., Martorana, G., Meucci, E., Castelli, A., Modulation of alkaline phosphatase in different organs by ascorbic acid and related compounds, <<ACTA VITAMINOLOGICA ET ENZYMOLOGICA>>, 1983; 5 (4): 219-224 [http://hdl.handle.net/10807/10005] |
Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |