NOVEL MEMBERS OF THE PLEXIN FAMILY AND USES THEREOF

The invention provides methods and compositions related to novel plexins. The polypeptides may be produced recombinantly from transformed host cells and from the disclosed plexin encoding nucleic acids or purified from human cells. The invention provides isolated plexin hybridization probes and primers capable of specifically hybridizing with the disclosed plexin genes, plexin-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in biopharmaceutical industry. The invention also provides novel plexin neuropilin multimeric receptor complexes for semaphorins and methods of use thereof, including but not limited to, the treatment and diagnosis of neurological disease and neuroregeneration, immune modulation, and viral and oncological diseases.