Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development.

Masciarelli, S., Bellissimo, T., Iosue, I., Fazi, F., Methods in Molecular Biology, Cancer Chemoprevention methods and protocols, Humana Press Inc., 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA 2016 <<METHODS IN MOLECULAR BIOLOGY>>, 1379: 69-76. 10.1007/978-1-4939-3191-0_6 [http://hdl.handle.net/10807/147541]

Methods in Molecular Biology

Masciarelli, Silvia;
2016

Abstract

Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development.
2016
Inglese
978-1-4939-3190-3
Humana Press Inc.
1379
Masciarelli, S., Bellissimo, T., Iosue, I., Fazi, F., Methods in Molecular Biology, Cancer Chemoprevention methods and protocols, Humana Press Inc., 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA 2016 <<METHODS IN MOLECULAR BIOLOGY>>, 1379: 69-76. 10.1007/978-1-4939-3191-0_6 [http://hdl.handle.net/10807/147541]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/147541
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