The death ligand TRAIL was discovered just over 10 years ago. In this chapter, we summarize the most important findings on the biochemistry, biology and potential therapeutic applicability of this promising novel cytokine. We address a number of eminent questions. How does TRAIL apoptosis signaling work and what is special about it? Why is this member of the tumor necrosis factor family of cytokines so interesting for cancer researchers and immunologists? What is the physiological role of the TRAIL–TRAIL receptor system? We cannot provide full answers to all of these questions; however, we intend to point out to the reader the most important unsolved scientific questions regarding the biology of this fascinating cytokine and its receptors.
Walczak, H., Koschny, R., Willen, D., Schader, M. B., Sykora, J., Ganten, T. M., Haas, T. L., Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts, in Debatin K, D. K., Fulda, F. S. (ed.), Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic ConceptsVolume 1, 26 May 2008, John Wiley and Sons, online journal 2008: 1 31- 92. 10.1002/9783527619665.ch2 [http://hdl.handle.net/10807/127898]
Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts
Haas, Tobias Longin
2008
Abstract
The death ligand TRAIL was discovered just over 10 years ago. In this chapter, we summarize the most important findings on the biochemistry, biology and potential therapeutic applicability of this promising novel cytokine. We address a number of eminent questions. How does TRAIL apoptosis signaling work and what is special about it? Why is this member of the tumor necrosis factor family of cytokines so interesting for cancer researchers and immunologists? What is the physiological role of the TRAIL–TRAIL receptor system? We cannot provide full answers to all of these questions; however, we intend to point out to the reader the most important unsolved scientific questions regarding the biology of this fascinating cytokine and its receptors.
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