Apoptosis is a distinctive feature in the physiology of the developing brain, but also a key event in pathological conditions of the adult brain. The basic mechanisms executing cell death by apoptosis are conserved among different tissues and in different conditions, while the initiating event(s) may be more specific. Magnesium appears to be an important player in the process, though it might exert opposite actions depending on extra/intracellular availability. Extracellular magnesium deficiency induces apoptosis, mainly through increased oxidative stress, while intracellular magnesium mobilization from intracellular stores and consequent increase of cytosolic free magnesium seem to act in the effector phase. The molecular mechanism and the physio-pathological meaning of these findings await further characterization. The issue is even more complex in the context of the brain, where many concurring factors may determine a pro- or anti-apoptotic environment. A deeper understanding of the yin-yang role of magnesium in apoptosis may cast light on the basic processes that regulate cell fate, and consequently may open up novel opportunities for a successful therapeutic intervention for all the pathological conditions where excessive and undue apoptosis takes place.

Trapani, V., Mastrototaro, L., Wolf, F. I., Magnesium in the Central Nervous System, in Vink, R. (ed.), Magnesium and the yin-yang interplay in apoptosis, University of Adelaide Press, Adelaide 2011: 85- 98. 10.1017/UPO9780987073051.006 [http://hdl.handle.net/10807/113277]

Magnesium in the Central Nervous System

Trapani
Primo
Writing – Original Draft Preparation
;
Valentina; Mastrototaro
Secondo
Writing – Original Draft Preparation
;
2011

Abstract

Apoptosis is a distinctive feature in the physiology of the developing brain, but also a key event in pathological conditions of the adult brain. The basic mechanisms executing cell death by apoptosis are conserved among different tissues and in different conditions, while the initiating event(s) may be more specific. Magnesium appears to be an important player in the process, though it might exert opposite actions depending on extra/intracellular availability. Extracellular magnesium deficiency induces apoptosis, mainly through increased oxidative stress, while intracellular magnesium mobilization from intracellular stores and consequent increase of cytosolic free magnesium seem to act in the effector phase. The molecular mechanism and the physio-pathological meaning of these findings await further characterization. The issue is even more complex in the context of the brain, where many concurring factors may determine a pro- or anti-apoptotic environment. A deeper understanding of the yin-yang role of magnesium in apoptosis may cast light on the basic processes that regulate cell fate, and consequently may open up novel opportunities for a successful therapeutic intervention for all the pathological conditions where excessive and undue apoptosis takes place.
Inglese
Magnesium and the yin-yang interplay in apoptosis
9780987073051
University of Adelaide Press
Trapani, V., Mastrototaro, L., Wolf, F. I., Magnesium in the Central Nervous System, in Vink, R. (ed.), Magnesium and the yin-yang interplay in apoptosis, University of Adelaide Press, Adelaide 2011: 85- 98. 10.1017/UPO9780987073051.006 [http://hdl.handle.net/10807/113277]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/113277
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? ND
social impact