In the last years, a dramatic amount of research has been performedincreasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopathological mechanisms promoting inflammation. In this narrative review we will discuss the biological relevance of B cell derived autoimmunity and in RA course, from disease onset to remission achievement.
Alivernini, S., Tolusso, B., Fedele, A. L., Di Mario, C., Ferraccioli, G., Gremese, E., The B side of rheumatoid arthritis pathogenesis, <<PHARMACOLOGICAL RESEARCH>>, 2019; 149 (149): 104465-N/A. [doi:10.1016/j.phrs.2019.104465] [http://hdl.handle.net/10807/148152]
The B side of rheumatoid arthritis pathogenesis
Alivernini, Stefano;Tolusso, Barbara;Di Mario, Clara;Ferraccioli, Gianfranco;Gremese, Elisa
2019
Abstract
In the last years, a dramatic amount of research has been performedincreasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopathological mechanisms promoting inflammation. In this narrative review we will discuss the biological relevance of B cell derived autoimmunity and in RA course, from disease onset to remission achievement.
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