2024-03-29T04:57:38Zhttps://publicatt.unicatt.it/oai/requestoai:publicatt.unicatt.it:10807/2686972024-03-28T09:38:04Zcom_10807_41com_10807_1col_10807_200
Cognitive processing and pandemic: The role of social distancing on the processing of commercial logos
Scerrati E. (ORCID:0000-0002-4042-6140)
Villani C.
D'Ascenzo, S.
Scerrati, Elisa
Villani, Claudio
Lugli, L.
Brand logos
Distancing effect
Perception
Social distancing
Spaced
Settore M-PSI/01 - PSICOLOGIA GENERALE
Following the spread of the pandemic by COVID-19 social distancing has been imposed, which, along with other behaviors, changed our usual lifestyle. The aim of the present study is to investigate whether social distancing can influence the processing of stimuli such as commercial logos. During a size discrimination task, logos were presented on the screen in their original and spaced representation, belonging to three different categories (letters, symbols and social images). Results showed an effect of spacing (slower processing of spaced stimuli than original stimuli) modulated by the type of logo. Specifically, the effect emerged with logos that have a social dimension, while it was null with logos representing letters and abstract symbols.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/268697
10.1421/102710
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124758473
ita
volume:48
issue:2
firstpage:577
lastpage:585
numberofpages:9
issueyear:2021
journal:GIORNALE ITALIANO DI PSICOLOGIA
Societa Editrice Il Mulino
oai:publicatt.unicatt.it:10807/2274272024-03-20T18:12:56Zcom_10807_41com_10807_1col_10807_200
Exploring the relationship between adherence to a goal-directed fluid therapy protocol and outcome after major surgery
Perilli V. (ORCID:0000-0001-9655-4267)
Sollazzi L. (ORCID:0000-0002-2973-6236)
Aceto P. (ORCID:0000-0002-0228-0603)
Perilli, Valter
Luca, E.
Marusco, I.
Formicola, G. C.
Sollazzi, Liliana
Aceto, Paola
fluid-therapy
major surgery
outcome
monitoring
postoperative complications
Settore MED/41 - ANESTESIOLOGIA
The primary aim of this retrospective study was to evaluate whether adherence to a goal-directed fluid-therapy (GDFT) protocol affects the occurrence of postoperative complications in patients undergoing pancreaticoduodenectomy. The secondary aim was to investigate the relationship between blood loss and adherence to GDFT protocol.
As adherence to GDFT varies widely during high-risk surgery, we hypothesized that patients in the best quartile of adherence (>75%) had a better outcome when compared with those of the worst quartile (with adherence <=25%).
One hundred and three patients scheduled for pancreaticoduodenectomy underwent a stroke volume (SV)-guided fluid therapy using an uncalibrated pulse contour device (Vigileo/FloTrac system version 4.0, Edwards Lifesciences, Irvine, California, USA) according to the NICE (National Institute for Health and Care excellence) protocol.
The main finding of this study, with limitations because of the retrospective design, was that adherence to GDFT protocol may affect postoperative complication rate. In particular, we found a relevant lower postoperative complication rate when adherence was above 75%. Furthermore, blood loss was the main factor influencing the patient’s deviation from SV trigger.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/227427
10.1097/EJA.0000000000001700
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85132960833
info:eu-repo/semantics/altIdentifier/pmid/35759294
info:eu-repo/semantics/altIdentifier/wos/WOS:000820283700008
eng
volume:39
issue:7
firstpage:622
lastpage:626
numberofpages:5
issueyear:2022
journal:EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Lippincott Williams and Wilkins
oai:publicatt.unicatt.it:10807/2265612024-03-18T19:03:18Zcom_10807_41com_10807_1col_10807_200
The «Gruppi di Parola»: Searching the theoretical and practical underpinnings within a focused ethnographic perspective
Molgora S. (ORCID:0000-0002-2517-2373)
Tamanza G. (ORCID:0000-0003-4167-8857)
Saita E. (ORCID:0000-0003-0790-2819)
Poli, C. F.
Molgora, Sara
Tamanza, Giancarlo
Saita, Emanuela
content analysis
focused ethnography
Gruppi di Parola
separation
Settore M-PSI/08 - PSICOLOGIA CLINICA
The Gruppo di Parola is an intervention group for children having separated parents used in Italy since 2005. It can be defined as a short, preventive and support program which is meant for school-age children (6-12 years old) as well as for teenagers (13-17 years old). The aim of the current study was to discover the theoretical underpinnings of the Italian Gruppi di Parola according to a focused ethnographic perspective. The study involved 12 workers who have concluded their training at least two years before the research. They were interviewed and content analysis were conducted on their verbatim transcription. In particular, the qualitative analysis of the content (QRS*NVivo) and the thematic analysis of the elementary contexts (T-Lab) were done in a multimethodological perspective. Our analysis demonstrates the ultimate presence of four thematic clusters showing that the intervention is rooted in both theoretical elements (the theoretical and conceptual references) as well as in more practical ones (the way of leadership, the value of the group, the particular «use» of the words of participants) within an integrative perspective.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/226561
10.1421/105149
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145171377
ita
volume:49
issue:2
firstpage:341
lastpage:361
numberofpages:21
issueyear:2022
journal:GIORNALE ITALIANO DI PSICOLOGIA
Societa Editrice Il Mulino
oai:publicatt.unicatt.it:10807/2271172023-06-21T20:26:18Zcom_10807_41com_10807_1col_10807_209
Editorial: Digitalization for precision healthcare
Cascini, Fidelia (ORCID:0000-0001-6499-0734)
Beccia, Flavia
Causio, Francesco Andrea
Ricciardi, Walter (ORCID:0000-0002-5655-688X)
Cascini, Fidelia
Beccia, Flavia
Causio, Francesco Andrea
Muscat, Natasha Azzopardi
Ricciardi, Walter
Artificial Intelligence
COVID-19
digitalization
precision healthcare
public health
Settore MED/42 - IGIENE GENERALE E APPLICATA
N/A
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/227117
10.3389/fpubh.2022.1078610
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144137483
info:eu-repo/semantics/altIdentifier/pmid/36530708
info:eu-repo/semantics/altIdentifier/wos/WOS:000899638500001
eng
volume:10
issue:dicembre
firstpage:N/A
lastpage:N/A
issueyear:2022
journal:FRONTIERS IN PUBLIC HEALTH
info:eu-repo/semantics/openAccess
oai:publicatt.unicatt.it:10807/2620342024-02-10T03:57:46Zcom_10807_41com_10807_1col_10807_200
Efectos de la resolución del contrato por incumplimiento: restituciones e indemnización por daños en una perspectiva de comparación dentro de la latinidad jurídica
Nicolussi, Andrea (ORCID:0000-0002-4038-2432)
Troncoso, María Isabel
Nicolussi, Andrea
Restituciones
Resolución
Daños y perjuicios
Latinidad jurídica
Contratos
Derecho civil
Settore IUS/01 - DIRITTO PRIVATO
Il saggio analizza, con una chiave comparatistica all'interno della "latinità giuridica", le restituzioni derivanti dalla risoluzione per inadempimento. Mette a confronto le soluzioni accolte nel diritto italiano (latinità giuridica europea) e quelle di due sistemi giuridici latinoamericani, la Colombia e il Perù. Dal punto di vista della disciplina dedicata alla risoluzione e alle sue conseguenze, i codici italiano e peruviano sono i più avanzati, mentre quello colombiano, che risale al XIX secolo, lascia ampio spazio allo sviluppo giurisprudenziale di questo rimedio. In ogni caso, i tre sistemi giuridici sembrano convergere sul ruolo della restituzione come strumento per riportare le parti alla situazione economica precedente al contratto. Tuttavia, per quanto riguarda il fondamento della funzione di restituzione, persistono incertezze tra la condictio indebiti e le restituzioni specificamente disciplinate nell'ambito della risoluzione. Anche il legame reciproco tra le restituzioni dovute dalle due parti necessita di una messa a fuoco. Infine, il coordinamento tra restituzione e risarcimento del danno nel contesto della risoluzione sembra essere colto più chiaramente dalla dottrina italiana, alla quale la dottrina peruviana sembra avvicinarsi. Il risarcimento del danno deve essere compatibile con il fatto che la parte adempiente del contratto non è più tenuta all'osservanza del contratto e rinuncia al corrispettivo. Il risarcimento non può quindi includere il valore della prestazione non eseguita, ma deve tutelare la parte fedele al contratto in termini di interesse positivo al contratto, cioè il beneficio che avrebbe ottenuto utilizzando la prestazione dovuta se fosse stata eseguita.
The essay addresses the restitutions derived from the resolution for non-compliance in a comparative way within the “legal Latinity”. It compares the solutions accepted in Italian law (European legal latinity), and those of two Latin American legal systems, Colombia, and Peru. From the point of view of the discipline dedicated to resolution (termination) and its consequences, the Italian and Peruvian codes are the most advanced, while the Colombian one, which dates from the nineteenth century, leaves ample room for the jurisprudential development of this remedy. In any event, the three legal systems seem to converge on the role of restitution as a tool to return the parties to the economic situation prior to the contract. However, with regard to the basis of the restitution function, uncertainties persist between the condictio indebiti and restitutions specifically regulated in the framework of rhe resolution (termination). Even the reciprocal link between the restitutions owed by the two parties remains undeepened. Finally, the coordination between restitution and compensation for damages in the context of the resolution seems to be more clearly captured in the Italian doctrine, to which the Peruvian doctrine seems closer. Damages must be compatible with the fact that the fullfilling party of the contract no longer owes its observance to the contract, and waives the consideration. Damages cannot therefore include the value of the performance unfulfilled, but must protect the party who is faithful to the contract in terms of its positive interest in the contract, that is to say, the benefit that he would have obtained by using the performance due if it had been fulfilled.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/262034
10.18800/iusetveritas.202302.001
spa
issue:67
firstpage:9
lastpage:29
numberofpages:21
issueyear:2023
journal:IUS ET VERITAS
oai:publicatt.unicatt.it:10807/2321552024-03-18T18:52:42Zcom_10807_41com_10807_1col_10807_209
SGLT2i Increase Endogenous Glucose Production: That’s Good News!
Giaccari A. (ORCID:0000-0002-7462-7792)
Giaccari, Andrea
endogenous glucose production
SGLTi2
Settore MED/13 - ENDOCRINOLOGIA
N/A
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/232155
10.2337/dci22-0010
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131251516
info:eu-repo/semantics/altIdentifier/pmid/35653601
info:eu-repo/semantics/altIdentifier/wos/WOS:000886431800006
eng
volume:45
issue:6
firstpage:1301
lastpage:1302
numberofpages:2
issueyear:2022
journal:DIABETES CARE
American Diabetes Association Inc.
oai:publicatt.unicatt.it:10807/2285852024-03-12T14:02:17Zcom_10807_41com_10807_1col_10807_200
NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia
Locatelli F. (ORCID:0000-0002-7976-3654)
Locatelli, Franco
Pende, D.
Falco, M.
Della Chiesa, M.
Moretta, A.
Moretta, L.
GvL
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Natural killer (NK) cells are involved in innate defenses against viruses and tumors. Their function is finely tuned by activating and inhibitory receptors. Among the latter, killer immunoglobulin-like receptors and CD94/NKG2A recognize human leukocyte antigen (HLA) Class I molecules, allowing NK cells to discriminate between normal and aberrant cells, as well as to recognize allogeneic cells, because of their ability to sense HLA polymorphisms. This latter phenomenon plays a key role in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for high-risk acute leukemia patients transplanted from an NK-alloreactive donor. Different haplo-HSCT settings have been developed, either T depleted or T replete – the latter requiring graft-versus-host disease prophylaxis. A novel graft manipulation, based on depletion of αβ T cells and B cells, allows infusion of fully mature, including alloreactive, NK cells. The excellent patient clinical outcome underscores the importance of these innate cells in cancer therapy.
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/228585
10.1016/j.it.2018.04.009
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85047188414
info:eu-repo/semantics/altIdentifier/pmid/29793748
info:eu-repo/semantics/altIdentifier/wos/WOS:000436643200006
eng
volume:39
issue:7
firstpage:577
lastpage:590
numberofpages:14
issueyear:2018
journal:TRENDS IN IMMUNOLOGY
Elsevier Ltd
oai:publicatt.unicatt.it:10807/2338732023-06-21T17:54:18Zcom_10807_41com_10807_1col_10807_200
Biopsychosocial frailty and mild cognitive impairment subtypes: Findings from the Italian project on the epidemiology of Alzheimer's disease (IPREA)
Daniele, Antonio (ORCID:0000-0003-1641-5852)
Solfrizzi, Vincenzo
Scafato, Emanuele
Custodero, Carlo
Piazzolla, Giuseppina
Capogna, Lavinia
Procaccio, Annagrazia
Gandin, Claudia
Galluzzo, Lucia
Ghirini, Silvia
Matone, Alice
Dibello, Vittorio
Sardone, Rodolfo
Daniele, Antonio
Lozupone, Madia
Panza, Francesco
Alzheimer's disease
cognitive frailty
dementia
frailty
lifestyle
physical frailty
social frailty
Settore MED/26 - NEUROLOGIA
IntroductionFrailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial phenotypes. We operationalized a biopsychosocial frailty construct, estimating its association with mild cognitive impairment (MCI) and its subtypes. MethodsIn 1980, older individuals from the population-based Italian PRoject on the Epidemiology of Alzheimer's disease (IPREA), we investigated cross-sectional associations among biopsychosocial frailty, MCI, and its subtypes. ResultsParticipants with biopsychosocial frailty showed an increased odds ratio (OR) of MCI [OR: 4.36; 95% confidence interval (CI): 2.60-7.29; Fisher's exact p < 0.01], particularly for nonamnestic MCI single domain (naMCI-SD, OR:3.28; 95% CI: 1.35-7.97; Fisher's exact p = 0.02) and for nonamnestic MCI multiple domain (naMCI-MD, OR:6.92; 95% CI: 3.37-14.21; Fisher's exact p < 0.01). No statistically significant associations between amnestic MCI single or multiple domain and biopsychosocial frailty were observed. DiscussionIn a large, older Italian cohort, a biopsychosocial frailty phenotype was associated with MCI, in particular, could be associated with some of its subtypes, that is, naMCI-SD, and naMCI-MD.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/233873
10.1002/alz.12944
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147582395
info:eu-repo/semantics/altIdentifier/pmid/36757048
info:eu-repo/semantics/altIdentifier/wos/WOS:000929414900001
eng
issue:2023
firstpage:N/A
lastpage:N/A
issueyear:2
journal:ALZHEIMER'S & DEMENTIA
WILEY
oai:publicatt.unicatt.it:10807/2580362024-03-19T17:38:16Zcom_10807_41com_10807_1col_10807_200
Molecular characterization of pyrethroid resistance in field- collected populations of the pea aphid, Acyrthosiphon pisum
Mazzoni, E (ORCID:0000-0001-9845-6038)
Müller, V
Buer, B
Lueke, B
Mazzoni, Emanuele
Pym, A
Bass, C
Nauen, R
insecticide resistance
cytochrome P450
detoxification
RNAseq
CYP6CY12
Settore AGR/11 - ENTOMOLOGIA GENERALE E APPLICATA
Acyrthosiphon pisum Harris (Hemiptera: Aphididae) is a globally distributed and economically important aphid pest of leguminous crops including peas, broad beans, and alfalfa. Infestations weaken plants directly by feeding, and indirectly, by the transmission of yield-affecting plant viruses. Although pea aphid control strategies largely rely on the application of insecticides, cases of insecticide resistance under applied conditions have not yet been described. Here we investigated the molecular basis of high levels of pyrethroid resistance (up to >180-fold) in two strains of A. pisum, PYR-R1 and VR, collected in the field in France and Italy, respectively. Foliar bioassays revealed significant synergistic effects between deltamethrin and piperonyl butoxide (a cytochrome P450 (P450) inhibitor), and, to a lesser extent, S,S,S-tributyl phosphorotrithioate (an esterase inhibitor). P450 and esterase activities in both resistant strains were significantly higher compared to an insecticide susceptible reference strain SUS-1. Target-site resistance mutations in the voltage-gated sodium channel known to confer pyrethroid resistance in other aphid pest species were not detected in either resistant strain. However, transcriptome profiling identified the P450 gene CYP6CY12 as highly over-expressed in the resistant PYR-R1 strain compared to the SUS-1 strain, and real-time quantitative PCR showed that this gene is also significantly overexpressed (>30-fold) in the VR strain. Functional expression of recombinant CYP6CY12 revealed its catalytic capacity to hydroxylate deltamethrin, thus confirming its causal role in pyrethroid resistance. Our study uncovered a P450-mediated mechanism of pyrethroid resistance in A. pisum for the first time and will inform future resistance management tactics to control this pest.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/258036
10.1127/entomologia/2023/1848
info:eu-repo/semantics/altIdentifier/wos/WOS:000956044400001
eng
volume:43
issue:3
firstpage:627
lastpage:637
numberofpages:11
issueyear:2023
journal:ENTOMOLOGIA GENERALIS
E SCHWEIZERBARTSCHE VERLAGSBUCHHANDLUNG
oai:publicatt.unicatt.it:10807/2290402024-03-20T01:38:51Zcom_10807_41com_10807_1col_10807_200
Collocations terminologiques et extraction automatique : une étude pilote dans le domaine du commerce électronique
Silvia Calvi
Calvi, Silvia
collocations, terminologie, extraction automatique, commerce électronique, humanités numériques
Settore L-LIN/04 - LINGUA E TRADUZIONE - LINGUA FRANCESE
This article concentrates on the automatic extraction of collocations, defined by the Explanatory and Combinatorial Lexicology as phraseological units composed by two elements – the base and the collocate. The aim of this article is to propose a methodology to follow in order to automatically extract collocations from a terminological corpus. This method takes into account different measures: the syntactic dependences between the items of the collocation, their frequency, their tendency to co-occur (PMI) and their specificity to the e-commerce domain. After having explained the theoretical framework, the methodology is illustrated using a pilot study of the French terminology of e-commerce. In the pilot study, data were extracted from a corpus made up of e-commerce texts, which are drawn from a larger corpus called DIACOM-fr, a corpus in the process of being built at the University of Verona within the project Digital Humanities applied to foreign languages and literatures. Data extraction was primarily done using two tools: Stanza a Python natural language analysis package developed by the Stanford NLP group and TermoStat an automatic extractor tool developed at the Observatoire de Linguistique Sens-Texte of the University of Montreal.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229040
fre
issue:13
firstpage:75
lastpage:82
numberofpages:8
issueyear:2021
journal:ACADEMIC JOURNAL OF MODERN PHILOLOGY
oai:publicatt.unicatt.it:10807/2383552024-03-23T20:04:12Zcom_10807_41com_10807_1col_10807_200
Prosodic skills in children with Down syndrome and in typically developing children
Zanchi P. (ORCID:0000-0002-0985-2301)
Zampini, L.
Fasolo, M.
Spinelli, M.
Zanchi, Paola
Suttora, C.
Salerni, N.
Down syndrome
multi-word utterances
prosodic skills
syntactic development
Settore M-PSI/04 - PSICOLOGIA DELLO SVILUPPO E PSICOLOGIA DELL'EDUCAZIONE
Background Many studies have analysed language development in children with Down syndrome to understand better the nature of their linguistic delays and the reason why these delays, particularly those in the morphosyntactic area, seem greater than their cognitive impairment. However, the prosodic characteristics of language development in children with Down syndrome have been scarcely investigated. Aims To analyse the prosodic skills of children with Down syndrome in the production of multi-word utterances. Data on the prosodic skills of these children were compared with data on typically developing children matched on developmental age and vocabulary size. Between-group differences and the relationships between prosodic and syntactic skills were investigated. Methods & Procedures The participants were nine children with Down syndrome (who ranged in chronological age from 45 to 63 months and had a mean developmental age of 30 months) and 12 30-month-old typically developing children. The children in both groups had a vocabulary size of approximately 450 words. The children's spontaneous productions were recorded during observations of mother-child play sessions. Outcomes & Results Data analyses showed that despite their morphosyntactic difficulties, children with Down syndrome were able to master some aspects of prosody in multi-word utterances. They were able to produce single intonation multi-word utterances on the same level as typically developing children. In addition, the intonation contour of their utterances was not negatively influenced by syntactic complexity, contrary to what occurred in typically developing children, although it has to be considered that the utterances produced by children with Down syndrome were less complex than those produced by children in the control group. However, children with Down syndrome appeared to be less able than typically developing children to use intonation to express the pragmatic interrogative function. Conclusions & Implications The findings are discussed considering the effects of social experience on the utterance prosodic realization.
2016
info:eu-repo/semantics/article
https://hdl.handle.net/10807/238355
10.1111/1460-6984.12186
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84954383647
info:eu-repo/semantics/altIdentifier/pmid/26123669
info:eu-repo/semantics/altIdentifier/wos/WOS:000367671000006
eng
volume:51
issue:1
firstpage:74
lastpage:83
numberofpages:10
issueyear:2016
journal:INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
Taylor and Francis Ltd
oai:publicatt.unicatt.it:10807/2402052023-06-26T08:06:14Zcom_10807_41com_10807_1col_10807_200
Future Modulation of Gut Microbiota: From Eubiotics to FMT, Engineered Bacteria, and Phage Therapy
Airola, Carlo
Severino, Andrea
Porcari, Serena
Fusco, William
Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Cammarota, Giovanni (ORCID:0000-0002-3626-6148)
Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238)
Ianiro, Gianluca (ORCID:0000-0002-8318-0515)
Airola, Carlo
Severino, Andrea
Porcari, Serena
Fusco, William
Mullish, Benjamin H
Gasbarrini, Antonio
Cammarota, Giovanni
Ponziani, Francesca Romana
Ianiro, Gianluca
dysbiosis
eubiotics
fecal microbiota transplant
microbiota
phage therapy
rifaximin
Settore MED/12 - GASTROENTEROLOGIA
The human gut is inhabited by a multitude of bacteria, yeasts, and viruses. A dynamic balance among these microorganisms is associated with the well-being of the human being, and a large body of evidence supports a role of dysbiosis in the pathogenesis of several diseases. Given the importance of the gut microbiota in the preservation of human health, probiotics, prebiotics, synbiotics, and postbiotics have been classically used as strategies to modulate the gut microbiota and achieve beneficial effects for the host. Nonetheless, several molecules not typically included in these categories have demonstrated a role in restoring the equilibrium among the components of the gut microbiota. Among these, rifaximin, as well as other antimicrobial drugs, such as triclosan, or natural compounds (including evodiamine and polyphenols) have common pleiotropic characteristics. On one hand, they suppress the growth of dangerous bacteria while promoting beneficial bacteria in the gut microbiota. On the other hand, they contribute to the regulation of the immune response in the case of dysbiosis by directly influencing the immune system and epithelial cells or by inducing the gut bacteria to produce immune-modulatory compounds, such as short-chain fatty acids. Fecal microbiota transplantation (FMT) has also been investigated as a procedure to restore the equilibrium of the gut microbiota and has shown benefits in many diseases, including inflammatory bowel disease, chronic liver disorders, and extraintestinal autoimmune conditions. One of the most significant limits of the current techniques used to modulate the gut microbiota is the lack of tools that can precisely modulate specific members of complex microbial communities. Novel approaches, including the use of engineered probiotic bacteria or bacteriophage-based therapy, have recently appeared as promising strategies to provide targeted and tailored therapeutic modulation of the gut microbiota, but their role in clinical practice has yet to be clarified. The aim of this review is to discuss the most recently introduced innovations in the field of therapeutic microbiome modulation.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/240205
10.3390/antibiotics12050868
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85160341717
info:eu-repo/semantics/altIdentifier/pmid/37237771
info:eu-repo/semantics/altIdentifier/wos/WOS:000995502100001
eng
volume:12
issue:5
firstpage:868
lastpage:N/A
issueyear:N/A
journal:ANTIBIOTICS
MDPI
oai:publicatt.unicatt.it:10807/2366342024-03-20T22:30:44Zcom_10807_41com_10807_1col_10807_200
A registry for Dravet syndrome: The Italian experience
De Masi, Salvatore
Perulli, Marco
Battaglia, Domenica (ORCID:0000-0003-0491-4021)
Granata, Tiziana
Ferrari, Annarita
Pellegrin, Serena
Balestrini, Simona
Doccini, Viola
Giometto, Sabrina
Lucenteforte, Ersilia
De Masi, Salvatore
Giarola, Elisa
Brambilla, Isabella
Pieroni, Federica
Perulli, Marco
Battaglia, Domenica Immacolata
Specchio, Nicola
Ragona, Francesca
Granata, Tiziana
Pellacani, Simona
Ferrari, Annarita
Marini, Carla
Matricardi, Sara
Cesaroni, Elisabetta
Giordano, Lucio
Accorsi, Patrizia
Sciruicchio, Vittorio
Tinuper, Paolo
Messana, Tullio
Russo, Angelo
Pruna, Dario
Nosadini, Margherita
De Giorgis, Valentina
Caputo, Davide
Pellegrin, Serena
Lo Barco, Tommaso
Darra, Francesca
Dalla Bernardina, Bernardo
Guerrini, Renzo
SCN1A
epilepsy syndrome
natural history
rare disease
registry
Settore MED/39 - NEUROPSICHIATRIA INFANTILE
ObjectivesWe describe the Residras registry, dedicated to Dravet syndrome (DS) and to other phenotypes related to SCN1A mutations, as a paradigm of registry for rare and complex epilepsies. Our primary objectives are to present the tools and framework of the integrative platform, the main characteristics emerging from the patient cohort included in the registry, with emphasis on demographic, clinical outcome, and mortality. MethodsStandardized data of enrolled pediatric and adult patients were collected in 24 Italian expert centers and regularly updated at least on a yearly basis. Patients were prospectively enrolled, at registry starting, but historical retrospective data were also included. ResultsAt present, 281 individuals with DS and a confirmed SCN1A mutation are included. Most patients have data available on epilepsy (n = 263) and their overall neurological condition (n = 255), based on at least one follow-up update. Median age at first clinical assessment was 2 years (IQR 0-9) while at last follow-up was 11 years (IQR 5-18.5). During the 7-year activity of the registry, five patients died resulting in a mortality rate of 1.84 per 1000-person-years. When analyzing clinical changes over the first 5-year follow-up, we observed a significant difference in cognitive function (P < 0.001), an increased prevalence of behavioral disorders including attention deficit (P < 0.001), a significant worsening of language (P = 0.001), and intellectual disability (P < 0.001). SignificanceThe Residras registry represents a large collection of standardized national data for the DS population. The registry platform relies on a shareable and interoperable framework, which promotes multicenter high-quality data collection. In the future, such integrated platform may represent an invaluable asset for easing access to cohorts of patients that may benefit from clinical trials with emerging novel therapies, for drug safety monitoring, and for delineating natural history. Its framework makes it improvable based on growing experience with its use and easily adaptable to other rare and complex epilepsy syndromes.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/236634
10.1002/epi4.12730
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85152445996
info:eu-repo/semantics/altIdentifier/pmid/36938796
info:eu-repo/semantics/altIdentifier/wos/WOS:000966513000001
eng
issue:MARZO
firstpage:1
lastpage:18
numberofpages:18
issueyear:2023
journal:EPILEPSIA OPEN
info:eu-repo/semantics/openAccess
WILEY
oai:publicatt.unicatt.it:10807/2506202023-09-13T23:16:37Zcom_10807_41com_10807_1col_10807_200
Reconstitution of repertoire of natural killer cell receptors after transplantation: just a question of time?
Locatelli, F (ORCID:0000-0002-7976-3654)
Locatelli, Franco
Bertaina, A
N/A
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
N/A
2010
info:eu-repo/semantics/article
https://hdl.handle.net/10807/250620
10.1038/bmt.2010.116
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77954844322
info:eu-repo/semantics/altIdentifier/pmid/20531444
info:eu-repo/semantics/altIdentifier/wos/WOS:000278573600002
eng
volume:45
issue:6
firstpage:968
lastpage:969
numberofpages:2
issueyear:2010
journal:BONE MARROW TRANSPLANTATION
NATURE PUBLISHING GROUP
oai:publicatt.unicatt.it:10807/2330272023-11-20T17:12:21Zcom_10807_41com_10807_1col_10807_200
Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Richeldi, Luca (ORCID:0000-0001-8594-1448)
Leone, Paolo M
Peljto, Anna L
Blumhagen, Rachel Z
Walts, Avram D
Cardwell, Jonathan
Powers, Julia
Corte, Tamera J
Dickinson, Joanne L
Glaspole, Ian
Moodley, Yuben P
Vasakova, Martina Koziar
Bendstrup, Elisabeth
Davidsen, Jesper R
Borie, Raphael
Crestani, Bruno
Dieude, Philippe
Bonella, Francesco
Costabel, Ulrich
Gudmundsson, Gunnar
Donnelly, Seamas C
Egan, Jim
Henry, Michael T
Keane, Michael P
Kennedy, Marcus P
Mccarthy, Cormac
Mcelroy, Aoife N
Olaniyi, Joshua A
O'Reilly, Katherine M A
Richeldi, Luca
Leone, Paolo Maria
Poletti, Venerino
Puppo, Francesco
Tomassetti, Sara
Luzzi, Valentina
Kokturk, Nurdan
Mogulkoc, Nesrin
Fiddler, Christine A
Hirani, Nikhil
Jenkins, Gisli
Maher, Toby M
Molyneaux, Philip L
Parfrey, Helen
Braybrooke, Rebecca
Blackwell, Timothy S
Jackson, Peter D
Nathan, Steven D
Porteous, Mary K
Brown, Kevin K
Christie, Jason D
Collard, Harold R
Eickelberg, Oliver
Foster, Elena E
Gibson, Kevin F
Glassberg, Marilyn
Kass, Daniel
Kropski, Jonathan A
Lederer, David
Linderholm, Angela L
Loyd, Jim
Mathai, Susan K
Montesi, Sydney B
Noth, Imre
Oldham, Justin M
Palmisciano, Amy J
Reichner, Cristina A
Rojas, Mauricio
Roman, Jesse
Schluger, Neil
Shea, Barry S
Swigris, Jeffrey J
Wolters, Paul J
Zhang, Yingze
Prele, Cecilia M A
Enghelmayer, Juan I
Otaola, Maria
Ryerson, Christopher J
Salinas, Mauricio
Sterclova, Martina
Gebremariam, Tewodros H
Myllärniemi, Marjukka
Carbone, Roberto
Furusawa, Haruhiko
Hirose, Masaki
Inoue, Yoshikazu
Miyazaki, Yasunari
Ohta, Ken
Ohta, Shin
Okamoto, Tsukasa
Kim, Dong Soon
Pardo, Annie
Selman, Moise
Aranda, Alvaro U
Park, Moo Suk
Park, Jong Sun
Song, Jin Woo
Molina-Molina, Maria
Planas-Cerezales, Lurde
Westergren-Thorsson, Gunilla
Smith, Albert V
Manichaikul, Ani W
Kim, John S
Rich, Stephen S
Oelsner, Elizabeth C
Barr, R Graham
Rotter, Jerome I
Dupuis, Josee
O'Connor, George
Vasan, Ramachandran S
Cho, Michael H
Silverman, Edwin K
Schwarz, Marvin I
Steele, Mark P
Lee, Joyce S
Yang, Ivana V
Fingerlin, Tasha E
Schwartz, David A
Genetic Association Studies
Interstitial Lung Disease
TOPMed
Telomerase
Whole Genome Sequencing
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
Rationale: Idiopathic pulmonary fibrosis is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to non-genetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, and exome studies have also been reported to associate with IPF. However, the extent to which rare variants genome-wide may contribute to the risk of IPF remains unknown. Objectives: We used whole-genome sequencing to investigate the role of rare variants, genome-wide, on IPF risk. Methods: As part of the Trans-Omics for Precision Medicine Program, we sequenced 2,180 cases of IPF. Association testing focused on the aggregated effect of rare variants (minor allele frequency ≤0.01) within genes or regions. We also identified individual variants that are influential within genes and estimated the heritability of IPF based on rare and common variants. Measurements and main results: Rare variants in both TERT and RTEL1 were significantly associated with IPF. A single rare variant in each of the TERT and RTEL1 genes was found to consistently influence the aggregated test statistics. There was no significant evidence of association with other previously reported rare variants. The SNP-heritability of IPF was estimated to be 32% (s.e. 3%). Conclusions: Rare variants within the TERT and RTEL1 genes and well-established common variants have the largest contribution to IPF risk overall. Efforts in risk profiling or development of therapies for IPF that focus on TERT, RTEL1, common variants, and environmental risk factors are likely to have the largest impact on this complex disease.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/233027
10.1164/rccm.202207-1331OC
info:eu-repo/semantics/altIdentifier/pmid/36602845
eng
volume:2023
issue:Jan 5
firstpage:1
lastpage:5
numberofpages:5
issueyear:2023
journal:AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
oai:publicatt.unicatt.it:10807/2259512024-03-20T22:41:21Zcom_10807_41com_10807_1col_10807_200
Effectiveness of vaccination against SARS-CoV-2 Omicron variant infection, symptomatic disease, and hospitalization: a systematic review and meta-analysis
Farina, Sara
Castagna, Carolina
Stefanelli, Paola
Boccia, Stefania (ORCID:0000-0002-1864-749X)
Rezza, Giovanni
Meggiolaro, Angela
Sane Schepisi, Monica
Farina, Sara
Castagna, Carolina
Mammone, Alessia
Siddu, Andrea
Stefanelli, Paola
Boccia, Stefania
Rezza, Giovanni
Booster dose
Sars-Cov2 vaccine
effectiveness
omicron VOC Sars-Cov2 vaccine
risk of hospitalization
symptomatic omicron infection
waning immunity
Settore MED/42 - IGIENE GENERALE E APPLICATA
Background This meta-analysis aims to assess the effectiveness of the current Sars-Cov2 vaccine regimens against Omicron infection. A secondary endpoint aims to investigate the waning effectiveness of primary vaccination against symptomatic infection and related hospitalization. Research design and methods The systematic review started on 1 December 2021 and was concluded on 1 March 2022. Random-effects frequentist meta-analyses and multiple meta-regressions were performed. Results In total, 15 studies are included in the quantitative synthesis. According to the meta-analysis results, the overall risk of Sars-Cov2 infection in vaccinated individuals is on average 31 center dot 5% lower than the infection risk in unvaccinated while vaccinated with one booster dose have a 70 center dot 4% risk reduction of Omicron infection compared to unvaccinated. In particular, one booster dose significantly decreases by 69% the risk of symptomatic Omicron infection with respect to unvaccinated. Six months after the primary vaccination, the average risk reduction declines to 22% against symptomatic infection and to 55% against hospitalization. Conclusions Primary vaccination does not provide sufficient protection against symptomatic Omicron infection. Although the effectiveness of the primary vaccination against hospitalization due to Omicron remains significantly above 50% after 3 months, it dramatically fades after 6 months.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/225951
10.1080/14760584.2022.2130773
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141716936
info:eu-repo/semantics/altIdentifier/pmid/36242513
info:eu-repo/semantics/altIdentifier/wos/WOS:000868444800001
eng
volume:21
issue:12
firstpage:1831
lastpage:1841
numberofpages:11
issueyear:2022
journal:EXPERT REVIEW OF VACCINES
info:eu-repo/semantics/openAccess
TAYLOR & FRANCIS LTD
oai:publicatt.unicatt.it:10807/2446352023-07-25T23:07:24Zcom_10807_41com_10807_1col_10807_200
From the Exclusive to the Excessive. Lake Garda's Long History of Tourism from the Belle Époque to Overtourism
Pasini M. P. (ORCID:0000-0002-1495-2542)
Pasini, Maria Paola
history of tourism, overtourism, sustainability, lake Garda, growth.
Settore SECS-P/12 - STORIA ECONOMICA
There are destinations that have a long tourism history marked by different transformations and phases and generally with a continuous growth of the tourism phenomenon. In recent years, some of these locations are overwhelmed by overtourism, which focuses on specific places because of their beauty, notoriety, history and reputation. Recently local governances are beginning to implement sustainable strategies to curb flows and mitigate the impacts on the territory of tourism excesses. This is the only opportunity for the destination to continue its life and avoid decline: a new model of sustainable rejuvenation. The paper sets out to analyze some aspects of the long-term history of Lake Garda, one of the most popular destinations in Italy. Starting from a tourism history that has been mainly established since the 19th century with a very "exclusive" form, this contribution aims to focus on the main trends that have seen Garda's attractiveness grow over the decades. It also analyzes the problem of "overtourism" that has affected some lake locations in recent years and the strategies implemented at the local level to contain this phenomenon.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/244635
10.30958/ajt.X-Y-Z
eng
volume:Volume 10
issue:3
firstpage:221
lastpage:242
numberofpages:22
issueyear:2023
journal:ATHENS JOURNAL OF TOURISM
oai:publicatt.unicatt.it:10807/2318532024-01-31T00:27:07Zcom_10807_41com_10807_1col_10807_200
Uk, la faticosa mitologia della stabilità politica
Zotti (ORCID:0000-0002-6034-4919)
Zotti, Antonio
Sistema politico britannico
Settore SPS/04 - SCIENZA POLITICA
Negli ultimi tempi il sistema politico britannico pare in crisi: è in atto un declino dell’incarnazione per antonomasia del “modello Westminster” verso una situazione di sempre maggior disordine e imprevedibilità? Un’analisi per capire.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231853
ita
volume:2023
issue:1
firstpage:33
lastpage:39
numberofpages:7
issueyear:2023
journal:VITA E PENSIERO
oai:publicatt.unicatt.it:10807/2369752024-03-23T02:33:05Zcom_10807_41com_10807_1col_10807_200
Asthma expectations predict symptoms over time: a longitudinal cohort study
Pagnini, F (ORCID:0000-0003-1612-4211)
Volpato, E (ORCID:0000-0003-0266-6386)
Poletti, V (ORCID:0000-0001-7458-7498)
Cavalera, C (ORCID:0000-0001-9309-0874)
Spina, F
Pagnini, Francesco
Volpato, Eleonora
Poletti, Valentina
Cavalera, Cesare Massimo
Graziano, F
Spina, Francesca
Banfi, P
illness expectations, mind/body connection, asthma, placebo, nocebo
Settore M-PSI/08 - PSICOLOGIA CLINICA
Background: Illness expectations are cognitive schemas, both explicit and implicit, describing
how symptoms are expected to be in the future. They can be particularly relevant to
disease in a mind/body framework. Asthma is a condition in which the psychological aspects
can highly influence the body, but no study has directly explored these specific expectations,
and no dedicated assessment tools are available.
Methods: We developed a questionnaire to assess the illness expectations, together with an
ad hoc version of the Implicit Association Test (IAT). We tested its factorial structure, and
the internal and test–retest validity, recruiting a sample of 183 asthmatic people. We also
explored the convergent validity and the correlations with objective and subjective clinical
assessments.
Results: Data suggested a three-factorial structure of the questionnaire into expectations
about future symptoms, change in current health status, and rigidity of these expectations.
The questionnaire showed good psychometric properties and strong associations with the
other considered outcomes, including implicit expectations. The implicit evaluation, however,
lacked test–retest reliability.
Conclusion: The questionnaire is a valid tool to assess illness expectations in people with
asthma. The two expectation scales are highly related, and the implicit expectations are
moderately associated with the explicit ones. The lack of stability related to IAT results may
reflect a lack of stability of the implicit expectations. The implications for the mind/body
framework still need to be fully explored.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/236975
10.1183/13993003.congress-2022.1616
info:eu-repo/semantics/altIdentifier/wos/WOS:000893392402200
eng
volume:60
issue:60
firstpage:1616
lastpage:1622
numberofpages:7
issueyear:2022
journal:EUROPEAN RESPIRATORY JOURNAL
EUROPEAN RESPIRATORY SOC JOURNALS LTD
oai:publicatt.unicatt.it:10807/2323762023-06-21T11:30:49Zcom_10807_41com_10807_1col_10807_200
Lentil seed coat as a source of phenolic compounds: influence of geographical origin and genotype
Senizza B.
Lucini L. (ORCID:0000-0002-5133-9464)
Galgano, F.
Condelli, N.
Tolve, R.
Scarpa, T.
Caruso, M. C.
Senizza, Biancamaria
Marzario, S.
Lucini, Luigi
Food by-products
Functional components
Lentil seed coat
Metabolomics
Polyphenols
UHPLC/QTOF-MS
Settore AGR/13 - CHIMICA AGRARIA
Lentils (Lens culinaris spp.) are promising legumes whose seed coats, the by-products produced from dehulling, can represent a valuable source of functional components. This work aimed at valorizing lentils seed coat as functional ingredients, by investigating its profile across 11 genotypes grown in two different growing locations in Italy. The total phenolic, flavonoids, and condensed tannins contents (mg/g dry weight,) ranged from 30.60 to 70.37 gallic acid equivalents, 0.86 to 2.21 catechin equivalents, and 22.34 to 77.49 catechin equivalents, respectively. The untargeted phenolic profiling through UHPLC/QTOF-MS, followed by multivariate statistics, revealed differences in the quality and quantity of polyphenols. A broad and diverse profile could be highlighted, including 420 compounds, mainly ascribable to flavonoids, phenolic acids, and low-molecular-weight phenolic compounds. Unsupervised cluster analysis highlighted that origin is hierarchically more important than genotype in determining the phenolic profiles. Pearson’s correlation analysis showed that color was only partially related to phenolic content, while the geographic location and the genotype were more relevant. The significant accumulation of phenolics in some genotypes suggests that the genetic background should be taken into account, when lentils seed coat is to be included in food design as a sustainable source of phenolic compounds.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/232376
10.1007/s11694-022-01711-9
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142740115
info:eu-repo/semantics/altIdentifier/wos/WOS:000889029400001
eng
volume:17
issue:2
firstpage:N/A
lastpage:N/A
numberofpages:10
issueyear:2023
journal:JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
Springer
oai:publicatt.unicatt.it:10807/2227122023-06-21T15:51:11Zcom_10807_41com_10807_1col_10807_200
Managing Children's Fears during the COVID-19 Pandemic: Strategies Adopted by Italian Caregivers
Landoni, Marta (ORCID:0000-0003-0082-1565)
Ionio, Chiara (ORCID:0000-0002-0163-3841)
Giordano, Francesca (ORCID:0000-0002-2959-2850)
Landoni, Marta
Silverio, Sergio A
Ionio, Chiara
Giordano, Francesca
COVID-19
children
content analysis
coping strategies
family resilience
fear
parents
qualitative
Settore M-PSI/04 - PSICOLOGIA DELLO SVILUPPO E PSICOLOGIA DELL'EDUCAZIONE
Background: Life-threatening events, such as the COVID-19 pandemic, may generate feelings of insecurity and fear in the affected population, particularly children. Parents' ability to help children cope with negative emotions is essential during challenging periods. The current study aims to analyse the coping strategies adopted by Italian caregivers concerning their children's fears about COVID-19. Method: An online survey was administered during the Italian lockdown to 649 parents of at least one child aged 5 to 17 years old. Respondents completed the survey for themselves and their children. In addition, a qualitative content analysis of the data from the open-ended question was conducted (N = 569; 87.9% women; M-Age = 45 years). Results: Several themes were identified. Firstly, families' primary approach was 'communication and meaning-making'. Secondly, another essential strategy was 'the importance of safe space', enabled by keeping routine in place and creating a loving and caring environment. Thirdly, other factors relevant to managing children's fears were 'adaptation', 'religion', 'a positive attitude', and 'humour and hope'. Finally, the last two strategies significant and valuable for Italian families were 'flexibility' and 'maintaining virtual contacts. Conclusion: During the pandemic COVID-19, parents may have used various strategies to protect their children from stress. Future research could investigate single parents' coping strategies explicitly developed during the COVID-19 lockdown.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/222712
10.3390/ijerph191811699
info:eu-repo/semantics/altIdentifier/pmid/36141968
info:eu-repo/semantics/altIdentifier/wos/WOS:000856457800001
eng
volume:19
issue:18
firstpage:1
lastpage:12
numberofpages:12
issueyear:2022
journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
MDPI
oai:publicatt.unicatt.it:10807/2352332024-03-23T18:15:33Zcom_10807_41com_10807_1col_10807_200
Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
Calabresi, Paolo (ORCID:0000-0003-0326-5509)
Primiano, Guido
Servidei, Serenella (ORCID:0000-0001-8478-2799)
Singh, Bhagteshwar
Lant, Suzannah
Cividini, Sofia
Cattrall, Jonathan W S
Goodwin, Lynsey C
Benjamin, Laura
Michael, Benedict D
Khawaja, Ayaz
Matos, Aline de Moura Brasil
Alkeridy, Walid
Pilotto, Andrea
Lahiri, Durjoy
Rawlinson, Rebecca
Mhlanga, Sithembinkosi
Lopez, Evelyn C
Sargent, Brendan F
Somasundaran, Anushri
Tamborska, Arina
Webb, Glynn
Younas, Komal
Al Sami, Yaqub
Babu, Heavenna
Banks, Tristan
Cavallieri, Francesco
Cohen, Matthew
Davies, Emma
Dhar, Shalley
Fajardo Modol, Anna
Farooq, Hamzah
Harte, Jeffrey
Hey, Samuel
Joseph, Albert
Karthikappallil, Dileep
Kassahun, Daniel
Lipunga, Gareth
Mason, Rachel
Minton, Thoma
Mond, Gabrielle
Poxon, Joseph
Rabas, Sophie
Soothill, Germander
Zedde, Marialuisa
Yenkoyan, Konstantin
Brew, Bruce
Contini, Erika
Cysique, Lucette
Zhang, Xin
Maggi, Pietro
van Pesch, Vincent
Lechien, Jérome
Saussez, Sven
Heyse, Alex
Brito Ferreira, Maria Lúcia
Soares, Cristiane N
Elicer, Isabel
Eugenín-von Bernhardi, Laura
Ñancupil Reyes, Waleng
Yin, Rong
Azab, Mohammed A
Abd-Allah, Foad
Elkady, Ahmed
Escalard, Simon
Corvol, Jean-Christophe
Delorme, Cécile
Tattevin, Pierre
Bigaut, Kévin
Lorenz, Norbert
Hornuss, Daniel
Hosp, Jona
Rieg, Siegbert
Wagner, Dirk
Knier, Benjamin
Lingor, Paul
Winkler, Andrea Sylvia
Sharifi-Razavi, Athena
Moein, Shima T
Seyedalinaghi, Seyedahmad
Jamalimoghadamsiahkali, Saeidreza
Morassi, Mauro
Padovani, Alessandro
Giunta, Marcello
Libri, Ilenia
Beretta, Simone
Ravaglia, Sabrina
Foschi, Matteo
Calabresi, Paolo
Primiano, Guido Alessandro
Servidei, Serenella
Biagio Mercuri, Nicola
Liguori, Claudio
Pierantozzi, Mariangela
Sarmati, Loredana
Boso, Federica
Garazzino, Silvia
Mariotto, Sara
Patrick, Kimani N
Costache, Oana
Pincherle, Alexander
Klok, Frederikus A
Meza, Roger
Cabreira, Verónica
Valdoleiros, Sofia R
Oliveira, Vanessa
Kaimovsky, Igor
Guekht, Alla
Koh, Jasmine
Fernández Díaz, Eva
Barrios-López, José María
Guijarro-Castro, Cristina
Beltrán-Corbellini, Álvaro
Martínez-Poles, Javier
Diezma-Martín, Alba María
Morales-Casado, Maria Isabel
García García, Sergio
Breville, Gautier
Coen, Matteo
Uginet, Marjolaine
Bernard-Valnet, Raphaël
Du Pasquier, Renaud
Kaya, Yildiz
Abdelnour, Loay H
Rice, Claire
Morrison, Hamish
Defres, Sylviane
Huda, Saif
Enright, Noelle
Hassell, Jane
D'Anna, Lucio
Benger, Matthew
Sztriha, Laszlo
Raith, Eamon
Chinthapalli, Krishna
Nortley, Ro
Paterson, Ro
Chandratheva, Arvind
Werring, David J
Dervisevic, Samir
Harkness, Kirsty
Pinto, Ashwin
Jillella, Dinesh
Beach, Scott
Gunasekaran, Kulothungan
Rocha Ferreira Da Silva, Ivan
Nalleballe, Krishna
Santoro, Jonathan
Scullen, Tyler
Kahn, Lora
Kim, Carla Y
Thakur, Kiran T
Jain, Rajan
Umapathi, Thirugnanam
Nicholson, Timothy R
Sejvar, James J
Hodel, Eva Maria
Tudur Smith, Catrin
Solomon, Tom
Autonomic dysfunction
Settore MED/26 - NEUROLOGIA
BackgroundNeurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome.MethodsWe conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models.ResultsWe included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region.InterpretationNeurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/235233
10.1371/journal.pone.0263595
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131265462
info:eu-repo/semantics/altIdentifier/pmid/35653330
info:eu-repo/semantics/altIdentifier/wos/WOS:000843619700020
eng
volume:17
issue:6
firstpage:N/A
lastpage:N/A
issueyear:2022
journal:PLOS ONE
PUBLIC LIBRARY SCIENCE
oai:publicatt.unicatt.it:10807/2496742024-03-08T02:16:42Zcom_10807_41com_10807_1col_10807_200
Matriderm dermal substitute in the treatment of post traumatic hand’s fingertip tissue loss
Fulchignoni C.
Rocchi L. (ORCID:0000-0001-9983-3800)
Merendi G.
Fulchignoni, Camillo
Rocchi, Lorenzo
Cauteruccio, M.
Merendi, Gianfranco
dermal substitute
fingertip
Matriderm
skin graft
tissue loss
Settore MED/33 - MALATTIE APPARATO LOCOMOTORE
Introduction: Treatment of fingers tissue loss is particularly challenging as it often necessitates advanced reconstructive techniques such as flaps or grafts, with esthetic and functional results that are not always as good as hoped for, with long healing times. Recently, along with tissue engineering development, numerous types of dermal substitute have been commercialized, with promising possibilities of treatment in finger tissue loss. In the author's unit, Matriderm® is the most commonly used dermal substitute. As described by the manufacturer, this scaffold is designed to be covered with a split-thickness skin graft. In using a two-step procedure, the authors realized that in most cases of fingertips injuries, at three weeks follow-up, the wound appeared in an advanced state of healing, which permitted to avoid grafting. Material And Methods: Between October 2017 and October 2018, 27 fingers have been included in this study. Patients have been divided in two groups: those treated with Matriderm® alone (15 fingers) and those who had a skin graft three weeks after the first surgery (12 fingers). At the 6-month follow-up, authors evaluated the esthetic results with the Vancouver Scar Scale (VSS), the functional results with Quick Disability of the Arm, Shoulder and Hand (qDASH) score, and sensibility by the mean of two-point discrimination test (2-PD). Results: All outcomes were overlapping in patients treated with or without skin graft: mean VSS was 2.3, mean qDASH was 13.3, and mean 2-PD was 7.7 mm. Conclusions: The results obtained allow to consider Matriderm®, used also without skin graft coverage, as a valid solution for treatment of fingertip tissue loss.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/249674
10.1111/jocd.14115
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85103641489
info:eu-repo/semantics/altIdentifier/pmid/33786967
info:eu-repo/semantics/altIdentifier/wos/WOS:000637421600001
eng
volume:21
issue:2
firstpage:750
lastpage:757
numberofpages:8
issueyear:2022
journal:JOURNAL OF COSMETIC DERMATOLOGY
John Wiley and Sons Inc
oai:publicatt.unicatt.it:10807/2680752024-03-27T00:59:22Zcom_10807_41com_10807_1col_10807_200
How priming with body odors affects decision speeds in consumer behavior
Giglioli, Irene Alice Chicchi (ORCID:0000-0003-2577-0039)
Alcañiz, Mariano
Chicchi Giglioli, Irene Alice Margherita
Carrasco-Ribelles, Lucia A.
Minissi, Maria Eleonora
López, Cristina Gil
Semin, Gün R.
Body Odor
Consumer Behavior
willingness to pay
Settore M-PSI/01 - PSICOLOGIA GENERALE
To date, odor research has primarily focused on the behavioral effects of common odors on consumer perception and choices. We report a study that examines, for the first time, the effects of human body odor cues on consumer purchase behaviors. The influence of human chemosignals produced in three conditions, namely happiness, fear, a relaxed condition (rest), and a control condition (no odor), were examined on willingness to pay (WTP) judgments across various products. We focused on the speed with which participants reached such decisions. The central finding revealed that participants exposed to human odors reached decisions significantly faster than the no odor control group. The main driving force is that human body odors activate the presence of others during decision-making. This, in turn, affects response speed. The broader implications of this finding for consumer behavior are discussed.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/268075
10.1038/s41598-023-27643-y
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85146194939
info:eu-repo/semantics/altIdentifier/pmid/36635353
info:eu-repo/semantics/altIdentifier/wos/WOS:000962604100044
eng
volume:13
issue:N/A
firstpage:N/A
lastpage:N/A
issueyear:N/A
journal:SCIENTIFIC REPORTS
info:eu-repo/semantics/openAccess
NATURE PORTFOLIO
oai:publicatt.unicatt.it:10807/2298762024-03-18T18:24:36Zcom_10807_41com_10807_1col_10807_200
Inhibition of natural killer cell cytotoxicity by interleukin-6: Implications for the pathogenesis of macrophage activation syndrome
Locatelli F. (ORCID:0000-0002-7976-3654)
Cifaldi, L.
Prencipe, G.
Caiello, I.
Bracaglia, C.
Locatelli, Franco
De Benedetti, F.
Strippoli, R.
NK
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Objective Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of interleukin-6 (IL-6) in the serum and synovial fluid, and impairment of natural killer (NK) cell function is often observed. This study was undertaken to evaluate a possible link between these 2 biologic findings and whether they may be associated with the development of macrophage activation syndrome, a condition frequently observed in systemic JIA. Methods Splenocytes from wild-type (WT) or IL-6-transgenic (Tg) mice were evaluated for NK cell cytotoxicity using a 51Cr-release assay. Numbers of NK cells and expression of perforin, granzyme B, CD69, and CD107a were evaluated by flow cytometry. Human peripheral blood mononuclear cells (PBMCs) isolated from healthy donors were treated with IL-6 and cultured in the presence or absence of tocilizumab (TCZ), an IL-6 receptor blocker. Human polyclonal NK cells from healthy donor PBMCs were evaluated for cell cytotoxicity and expression of perforin, granzyme B, and CD107a. PBMCs harvested from patients with systemic JIA during periods of active or inactive disease were left untreated or treated with IL-6 in combination with soluble IL-6 receptor and analyzed for the expression of perforin and granzyme B. Results Splenic NK cell cytotoxicity was reduced in IL-6-Tg mice compared to WT mice. Levels of CD69 and CD107a showed no significant differences, whereas expression of perforin and granzyme B was impaired in NK cells from IL-6-Tg mice. Exposure of human peripheral blood NK cells to IL-6 led to reduced expression of perforin and granzyme B. Culturing human polyclonal NK cells in the presence of TCZ significantly increased cell cytotoxicity, and also increased expression of perforin and granzyme B. In patients with systemic JIA, a reduction in IL-6 plasma levels during disease remission correlated with the rescue of perforin and granzyme B expression in NK cells from these patients. Conclusion In both mice and humans, IL-6 down-modulated the cytotoxic activity of NK cells. This decrease was associated with reduced perforin and granzyme B levels in the absence of altered granule exocytosis.
2015
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229876
10.1002/art.39295
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84946022428
info:eu-repo/semantics/altIdentifier/pmid/26251193
info:eu-repo/semantics/altIdentifier/wos/WOS:000363881400029
eng
volume:67
issue:11
firstpage:3037
lastpage:3046
numberofpages:10
issueyear:2015
journal:ARTHRITIS & RHEUMATOLOGY
John Wiley and Sons Inc
oai:publicatt.unicatt.it:10807/2345112023-05-09T12:33:24Zcom_10807_41com_10807_1col_10807_200
Temperature control after cardiac arrest
Sandroni C. (ORCID:0000-0002-8878-2611)
Sandroni, Claudio
Natalini, D.
Nolan, J. P.
Cardiac arrest
Coma
Hypothermia
Hypoxic-ischemic brain injury
Temperature control
Settore MED/41 - ANESTESIOLOGIA
Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI. In 2002, one randomized trial and one quasi-randomized trial showed that temperature control targeted at 32–34 °C improved neurological outcome and mortality in patients who are comatose after cardiac arrest. However, following the publication of these trials, other studies have questioned the neuroprotective effects of hypothermia. In 2021, the largest study conducted so far on temperature control (the TTM-2 trial) including 1900 adults comatose after resuscitation showed no effect of temperature control targeted at 33 °C compared with normothermia or fever control. A systematic review of 32 trials published between 2001 and 2021 concluded that temperature control with a target of 32–34 °C compared with fever prevention did not result in an improvement in survival (RR 1.08; 95% CI 0.89–1.30) or favorable functional outcome (RR 1.21; 95% CI 0.91–1.61) at 90–180 days after resuscitation. There was substantial heterogeneity across the trials, and the certainty of the evidence was low. Based on these results, the International Liaison Committee on Resuscitation currently recommends monitoring core temperature and actively preventing fever (37.7 °C) for at least 72 h in patients who are comatose after resuscitation from cardiac arrest. Future studies are needed to identify potential patient subgroups who may benefit from temperature control aimed at hypothermia. There are no trials comparing normothermia or fever control with no temperature control after cardiac arrest.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/234511
10.1186/s13054-022-04238-z
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142541971
info:eu-repo/semantics/altIdentifier/pmid/36434649
info:eu-repo/semantics/altIdentifier/wos/WOS:000888741400001
eng
volume:26
issue:1
firstpage:361
lastpage:369
numberofpages:9
issueyear:2022
journal:CRITICAL CARE
info:eu-repo/semantics/openAccess
BioMed Central Ltd
oai:publicatt.unicatt.it:10807/2405342023-06-27T07:26:11Zcom_10807_41com_10807_1col_10807_200
Air pollution and plaque healing in acute coronary syndromes
Russo, Michele
Rinaldi, Riccardo
Camilli, Massimiliano
Bonanni, Alice
Basile, Mattia
Salzillo, Carmine
Colucci, Michele
Torre, Ilaria
Sanna, Tommaso (ORCID:0000-0002-5760-6885)
Liuzzo, Giovanna (ORCID:0000-0002-5714-0907)
Burzotta, Francesco (ORCID:0000-0002-6569-9401)
Trani, Carlo (ORCID:0000-0001-9777-013X)
Niccoli, Giampaolo (ORCID:0000-0002-3187-6262)
Crea, Filippo (ORCID:0000-0001-9404-8846)
Montone, Rocco A
Russo, Michele
Rinaldi, Riccardo
Camilli, Massimiliano
Bonanni, Alice
Caffè, Andrea
Basile, Mattia
Salzillo, Carmine
Colucci, Michele
Torre, Ilaria
Sanna, Tommaso
Liuzzo, Giovanna
Burzotta, Francesco
Trani, Carlo
Niccoli, Giampaolo
Crea, Filippo
Montone, Rocco Antonio
Acute coronary syndromes
Air pollution
Inflammation
Plaque healing
Thrombosis
Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
N/A
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/240534
10.1093/eurheartj/ehad319
info:eu-repo/semantics/altIdentifier/pmid/37264700
info:eu-repo/semantics/altIdentifier/wos/WOS:000999584400001
eng
issue:Jun 2
firstpage:321
lastpage:323
numberofpages:3
issueyear:2023
journal:EUROPEAN HEART JOURNAL
OXFORD UNIV PRESS
oai:publicatt.unicatt.it:10807/2195882024-03-20T01:39:53Zcom_10807_41com_10807_1col_10807_200
Leadership Skills, Style of Power and Influence over Regional Policies of Germany in the Post-Crisis Europe (2012-2015)
Valerio Alfonso Bruno
Bruno, Valerio Alfonso
Finzi, Giacomo
Germany, Regional Power, Europe, Leadership, Crisis
Settore SPS/04 - SCIENZA POLITICA
Since the Eurozone crisis, scholars framed different interpretations about the power role of Germany in Europe, pointing at the possible return of the “German question”. Recently, with the “Brexit”, the populist tensions within the EU and the election of Trump as US president, Germany on the contrary, was regarded as the last bastion of the liberal order by Western media. Starting from the premise that with the global economic crisis Germany acquired a supremacy position in Europe “by default”, we proceed by confuting the idea of Germany as a coercive hegemon, without falling into idealistic interpretations. To do so, we define an analytical framework distinguishing leadership and hegemony and insisting on the importance of the context of permanent multi-level crisis in Europe. The argument we advance is that between 2012 and 2015 Germany played a positive power role in Europe, exhibiting appreciable leadership skills, vast regional influence and, first of all, a style of power closer to a benign multilateral leadership than to a coercive unilateral hegemony. The empirical research is based on three case studies from dierent policy areas, the Banking Union (2012-2013), the European migration crisis (2014-2015) and the Russia-Ukraine conflict (2014-2015).
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/219588
10.21814/perspectivas.115
eng
issue:18
firstpage:28
lastpage:43
numberofpages:16
issueyear:2020
journal:Perspectivas. Journal of Political Science
oai:publicatt.unicatt.it:10807/2298732024-03-22T20:21:01Zcom_10807_41com_10807_1col_10807_200
γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes
Locatelli F. (ORCID:0000-0002-7976-3654)
Airoldi, I.
Bertaina, A.
Prigione, I.
Zorzoli, A.
Pagliara, D.
Cocco, C.
Meazza, R.
Loiacono, F.
Lucarelli, B.
Bernardo, M. E.
Barbarito, G.
Pende, D.
Moretta, A.
Pistoia, V.
Moretta, L.
Locatelli, Franco
HSCT
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
We prospectively assessed functional and phenotypic characteristics of γδ T lymphocytes up to 7 months after HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) depleted of αβ+ T cells and CD19+ B cells in 27 children with either malignant or nonmalignant disorders. We demonstrate that (1) γδ T cells are the predominant T-cell population in patients during the first weeks after transplantation, being mainly, albeit not only, derived from cells infused with the graft and expanding in vivo; (2) central-memory cells predominated very early posttransplantation for both Vδ1 and Vδ2 subsets; (3) Vδ1 cells are specifically expanded in patients experiencing cytomegalovirus reactivation and are more cytotoxic compared with those of children who did not experience reactivation; (4) these subsets display a cytotoxic phenotype and degranulate when challenged with primary acute myeloid and lymphoid leukemia blasts; and (5) Vδ2 cells are expanded in vitro after exposure to zoledronic acid (ZOL) and efficiently lyse primary lymphoid and myeloid blasts. This is the first detailed characterization of γδ T cells emerging in peripheral blood of children after CD19+ B-cell and αβ+ T-cell-depleted haplo-HSCT. Our results can be instrumental to the development of clinical trials using ZOL for improving γδ T-cell killing capacity against leukemia cells. This trial was registered at www.clinicaltrials.gov as #NCT01810120.
2015
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229873
10.1182/blood-2014-09-599423
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84927547046
info:eu-repo/semantics/altIdentifier/pmid/25612623
info:eu-repo/semantics/altIdentifier/wos/WOS:000354628100010
eng
volume:125
issue:15
firstpage:2349
lastpage:2358
numberofpages:10
issueyear:2015
journal:BLOOD
American Society of Hematology
oai:publicatt.unicatt.it:10807/2638362024-03-03T10:14:38Zcom_10807_41com_10807_1col_10807_95494
Temporomandibular disorders: the most common diagnostic approaches
RAFFAELLI, Luca (ORCID:0000-0003-4525-8446)
Saccomanno, Sabina
Saran, Stefano
Parpagliolo, Luca
Tasquier, Federico
Giannotta, Nicola
Kozokic, Jovana
Carganico, Andrea
Mastrapasqua, Rodolfo F.
Raffaelli, Luca
Levrini, Luca
Temporomandibular
Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE
Background: Temporomandibular disorders (TMDs) are a heterogeneous group of conditions involving the temporomandibular joint complex, and surrounding musculature and osseous components. They are a multifactorial disease that can be determined by organic, genetic aspects, oral parafunctional habits, and psychological stress. They have an annual incidence of more than 5% of the population and about 6% to 12% of the population is affected by symptoms. The diagnostic criteria (DC), introduced by Dworkin, is considered the standard system to diagnose this disease in a specific way. Imaging can support the diagnosis of TMD when history and physical examination findings are equivocal. The aim of the study was to evaluate instrumental examinations and therapies, clinicians prefer to use in different cases of TMDs. Methods: An anonymized survey, available in two languages (Italian and English), was given to 450 patients, 398 (120 males, 274 females and 4 who did not answer) of different private dental practices were considered, using Google Form (Google LLC, Mountain View, CA, USA) and used an electronic platform, from September 2021 to February 2022. There was no reminder sent to patients to let them feel free to answer. Results: We performed binary regression for oral bite prescription considering common symptoms and found that the most representative is jaw block (P=0.007, exponential value [EXP]=0.509), followed by TMJ noises (P=0.01, EXP=0.503) and feeling stressed (P=0.04, EXP=1.125) while headache and tinnitus resulted not significant. Conclusions: The study highlighted that magnetic resonance imaging (MRI) is the most instrumental examination adopted by the clinicians and the oral splint(bite) is the therapy most widespread nowadays, even if TMDs are a multifactorial disease that is not, probably, only linked to an alteration of dental occlusion.
2023
info:eu-repo/semantics/conferenceObject
https://hdl.handle.net/10807/263836
10.23736/s2724-6329.23.04845-3
info:eu-repo/semantics/altIdentifier/pmid/38127420
eng
volume:2023
issue:vol 72 -n.6
firstpage:147
lastpage:155
numberofpages:9
issueyear:2023
journal:MINERVA DENTAL AND ORAL SCIENCE
oai:publicatt.unicatt.it:10807/2594572024-03-14T05:59:01Zcom_10807_41com_10807_1col_10807_200
Temporal trends of frame expansion and paravalvular leak reduction after transcatheter aortic valve replacement with self-expandable prostheses
Russo, Giulio
Burzotta, Francesco (ORCID:0000-0002-6569-9401)
Pedicino, Daniela
Graziani, Francesca (ORCID:0000-0002-4520-5689)
Bruno, Piergiorgio (ORCID:0000-0002-1075-5808)
Locorotondo, Gabriella
Calabrese, Michele
Aurigemma, Cristina
Romagnoli, Enrico
Trani, Carlo (ORCID:0000-0001-9777-013X)
Russo, Giulio
Zambrano, Aniello
Burzotta, Francesco
Pedicino, Daniela
Graziani, Francesca
Cangemi, Stefano
Bianchini, Francesco
Bruno, Piergiorgio
Locorotondo, Gabriella
Calabrese, Michele
Aurigemma, Cristina
Romagnoli, Enrico
Trani, Carlo
Temporal trends
transcatheter aortic valve
paravalvular leak reduction
Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Background: Paravalvular leakage (PVL) is a common finding after transcatheter aortic valve replacement (TAVR) and affects late clinical outcome. It is more frequent with self-expandable (SE) transcatheter-heart-valve (THV). Few is known about SE-THV expansion after implantation. The purpose is to assess SE-THV frame expansion and its possible influence on PVL. Methods: We designed a prospective pilot study to assess the time-course of SE-THV frame dimensions and PVL after TAVR. Consecutive patients undergoing TAVR with SE-THV were enrolled. Prosthesis fluoroscopy and echocardiography were prospectively performed immediately after TAVR (T0) and before discharge (T1) to grade PVL. Prosthesis diameters were assessed in 2 fluoroscopic orthogonal views. PVL reduction ≥1+ from T0 to T1 at echocardiography was the primary study endpoint. Results: Twenty-five patients were enrolled. Mean interval between T0 and T1 evaluations was 5 days. Grade 1 or 2 was present in 76% of patients at T0 and in 68% at T1 (P=0.034). A total of 7 patients (28%) improved PVL ≥1 grade from T0 to T1. Differences between T0 and T1 fluoroscopic diameters were not statistically significant. When comparing the diameter changes according to PVL evolution, patients with PVL improvement (as compared with those without) had significantly larger minimum diameter increase at both annulus/inflow (P=0.016) and outflow/distal edge (P=0.027). Conclusions: PVL may improve in the early days after SE-THV and those patients with PVL improvement may have THV frame expansion. Further studies are needed to confirm such preliminary observations and to establish the clinical relevance of this phenomenon.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/259457
10.23736/S2724-5683.23.06368-8
info:eu-repo/semantics/altIdentifier/pmid/38088090
eng
issue:Dec 12
firstpage:N/A
lastpage:N/A
issueyear:2023
journal:MINERVA CARDIOLOGY AND ANGIOLOGY
oai:publicatt.unicatt.it:10807/2682632024-03-28T01:34:12Zcom_10807_41com_10807_1col_10807_209
Editorial: Virtual Reality, Augmented Reality and Video Games for Addressing the Impact of COVID-19 on Mental Health
Chicchi Giglioli, Irene Alice (ORCID:0000-0003-2577-0039)
Pallavicini, Federica
Chicchi Giglioli, Irene Alice Margherita
Kim, Gerard Jounghyun
Alcañiz, Mariano
Rizzo, Albert
virtual reality
augmented reality
video games
COVID-19
mental health
Settore M-PSI/01 - PSICOLOGIA GENERALE
The coronavirus disease 2019 (COVID-19) pandemic is having a significant impact on global healthcare, economics and general human well-being. In addition to the tragic effect of COVID-19 on the medical health of the global population, its ominous and physically invisible presence could have an enduring impact on mental health and the everyday life of millions of people worldwide. Thus far, 187 countries have been affected, with more than 5 million confirmed infections and over 345,000 deaths. The adverse impact on mental health concerns not only health care workers, who are facing exhausting work rhythms and the need to manage patients experiencing extreme suffering, but also millions of people forced into isolation and/or quarantine.
These conditions put health care workers as well as the general population at a high risk of developing stress-related psychopathological symptoms, anxiety disorders, depression, moral injury, and post-traumatic stress disorder (PTSD), with potential long-term consequences on their mental and physical health.
Numerous scientific studies have shown that, among various therapeutic programs, virtual reality (VR) and augmented reality (AR) represent highly specialized and effective tools for the prevention, assessment and treatment of mental health concerns, including stress-related psychopathological symptoms, depression, and anxiety disorders, such as PTSD. These technologies, in fact, can help patients both process the emotional aspects of traumatic memories and learn useful resources to better manage COVID-19 related stressors. Such approaches have been shown to be effective with victims of stress and trauma from other sources including war, natural disasters, interpersonal violence and terrorist attacks. Furthermore, various studies have demonstrated that people play video games (VGs) because of their inherent capacity to play a role as a distraction from undesirable emotional states, such as anxiety and stress, by providing a temporary diversion from (real-world) negative events or emotions. Different genres of VGs have proved capable of eliciting positive emotions and decreasing stress and anxiety in players, especially casual video games (CVGs) and exergames. Additionally, VR/AR games have also recently proven effective to decrease stress and anxiety in individuals.
It is in this context that we welcome contributions to this Research Topic entitled “Virtual Reality, Augmented Reality and Video Games for Addressing the Impact of COVID-19 on Mental Health”. Theoretical, empirical, experimental and case studies are welcome. All contributions should clearly address the practical and theoretical implications of the research reported, and short papers (2-5 pages) will be considered if they meet these criteria.
We therefore welcome submissions of Original Research and Reviews on the following topics:
•Application of VR/AR and VGs for psychological support during the COVID-19 crisis;
•Design and evaluation of VR/AR contents and VGs for the prevention and treatment of mental health concerns related to the COVID-19 pandemic;
•Applications that differentially consider the specific needs of frontline healthcare providers, COVID-19 survivors, previous trauma victims (military veterans etc.), and the general population;
•Possible uses of VR/AR and VGs at home, schools, hospitals and clinics for psychological support in the COVID-19 crisis and/or the methodologies and technologic approaches that will promote access and adoption in these settings;
•Theoretical perspective of understanding VR and VGs in the prevention and treatment of mental health concerns related to the COVID-19 pandemic;
•Potential impact (socio-cultural, economic and environmental) of VR and VGs for psychological support in the COVID-19 pandemic;
•Methods for promoting safety and infection prevention in the use of VR/AR head-mounted displays;
•Challenges and pitfalls in applying VR and VGs for psychological support in the COVID-19 pandemic purposes.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/268263
10.3389/frvir.2021.719358
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131127322
info:eu-repo/semantics/altIdentifier/wos/WOS:001023325100001
eng
volume:2
issue:N/A
firstpage:N/A
lastpage:N/A
issueyear:N/A
journal:FRONTIERS IN VIRTUAL REALITY
info:eu-repo/semantics/openAccess
FRONTIERS MEDIA SA
oai:publicatt.unicatt.it:10807/2330092023-06-21T14:35:47Zcom_10807_41com_10807_1col_10807_200
Protein-amino acid metabolism disarrangements: The hidden enemy of chronic age-related conditions
Calvani R. (ORCID:0000-0001-5472-2365)
Pasini, E.
Corsetti, G.
Aquilani, R.
Romano, C.
Picca, A.
Calvani, Riccardo
Dioguardi, F. S.
protein metabolism
sarcopenia
muscle wasting
amino acids
catabolism
inflammation
Settore MED/09 - MEDICINA INTERNA
Proteins are macro-molecules crucial for cell life, which are made up of amino acids (AAs). In healthy people, protein synthesis and degradation are well balanced. However, in the presence of hypercatabolic stimulation (i.e., inflammation), protein breakdown increases as the resulting AAs are consumed for metabolic proposes. Indeed, AAs are biochemical totipotent molecules which, when deaminated, can be transformed into energy, lipids, carbohydrates, and/or biochemical intermediates of fundamental cycles, such as the Krebs' cycle. The biochemical consequence of hyper-catabolism is protein disarrangement, clinically evident with signs such as sarcopenia, hypalbuminemia, anaemia, infection, and altered fluid compartmentation, etc. Hypercatabolic protein disarrangement (HPD) is often underestimated by clinicians, despite correlating with increased mortality, hospitalization, and morbidity quite independent of the primary disease. Simple, cheap, repeatable measurements can be used to identify HPD. Therefore, identification and treatment of proteins' metabolic impairment with appropriate measurements and therapy is a clinical strategy that could improve the prognosis of patients with acute/chronic hypercatabolic inflammatory disease. Here, we describe the metabolism of protein and AAs in hypercatabolic syndrome, illustrating the clinical impact of protein disarrangement. We also illustrate simple, cheap, repeatable, and worldwide available measurements to identify these conditions. Finally, we provide scientific evidence for HPD nutritional treatment.
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/233009
10.3390/nu10040391
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85044606597
info:eu-repo/semantics/altIdentifier/pmid/29565819
info:eu-repo/semantics/altIdentifier/wos/WOS:000435182900007
eng
volume:10
issue:4
firstpage:1
lastpage:11
numberofpages:11
issueyear:2018
journal:NUTRIENTS
MDPI
oai:publicatt.unicatt.it:10807/2266882024-03-18T20:57:56Zcom_10807_41com_10807_1col_10807_200
The joint impact of labour policies and the "Great Recession" on unemployment in Europe
Bruno R. L. (ORCID:0000-0002-3436-5046)
Dal Bianco, S.
Bruno, Randolph Luca
Signorelli, M.
Crisis
Labour market policies
Unemployment
Youth unemployment
Settore SECS-P/01 - ECONOMIA POLITICA
Settore SECS-P/02 - POLITICA ECONOMICA
Settore SECS-P/05 - ECONOMETRIA
Settore SECS-P/06 - ECONOMIA APPLICATA
The paper consists of an empirical analysis of the separate as well as joint impacts on total and youth unemployment of indicators of labour market policies on the one hand, and the financial crisis associated with the "Great Recession" on the other. In particular, we investigate labour market data in the past two decades for the Enlarged Europe and adopt a variable accounting for the idiosyncratic severity shock of the crisis. This time-varying and country-specific crisis variable enables us to test empirically and in a novel way the joint impact of labour market policies and the economic crisis on labour market dynamics even when accounting for common macro shocks.
2015
info:eu-repo/semantics/article
https://hdl.handle.net/10807/226688
10.1016/j.ecosys.2014.06.002
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925940011
https://www.sciencedirect.com/science/article/pii/S0939362514000776
info:eu-repo/semantics/altIdentifier/wos/WOS:000353601800002
eng
volume:39
issue:1
firstpage:3
lastpage:26
numberofpages:24
issueyear:2015
journal:ECONOMIC SYSTEMS
Elsevier B.V.
oai:publicatt.unicatt.it:10807/2276802024-02-29T08:22:28Zcom_10807_41com_10807_1col_10807_200
Quenching of oxygen-related defects in graphene oxide nanohybrid: Highly selective room-temperature ethanol sensor
Casotto A.
Sangaletti L. (ORCID:0000-0001-9312-5862)
Kaur, N.
Singh, M.
Casotto, Andrea
Arachchige, H. M. M. M.
Sangaletti, Luigi Ermenegildo
Comini, E.
sensors
photoemission
Settore FIS/03 - FISICA DELLA MATERIA
The presence of surface defects, such as epoxy and carbonyl groups, is known to control the charge-carrier transport in graphene oxide (GO). In addition, these surface entities also provide an opportunity to synthesize novel hybrid (NH) materials via chemical bonding. These hybrid materials are particularly interesting for sensing as they offer novel properties like larger surface area and improved physical/chemical properties. Herein, we are proposing a novel SiO2@GO-NH based room-temperature (RT) ethanol sensor. The NH is realized from solution-route by following the sol-gel chemistry of tetraethyl orthosilicate. The attachment of SiO2 with the GO network occurs via the formation of Si-O-C bonds, which also leads to the reduction in the atomic percentage of electron-withdrawing groups. This reduction results in the improvement in electron charge transport in GO, which leads to the RT detection of ethanol. Specifically, the charge transport in NH is found to be dominated by a field-driven temperature-independent 2D variable-range hopping mechanism. While the ethanol sensing mechanism is found to be governed by two processes, i.e., via direct interaction of ethanol with NH and interaction with chemisorbed oxygen ions on the Pt/Si@GO-NH interface. Detailed observations reveal that the SiO2-GO NH has great potential to be used as a biomarker for food quality control.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/227680
10.1063/5.0114607
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143980701
eng
volume:9
issue:4
firstpage:041407
lastpage:N/A
issueyear:2022
journal:APPLIED PHYSICS REVIEWS
American Institute of Physics Inc.
oai:publicatt.unicatt.it:10807/2404962024-03-20T17:33:39Zcom_10807_41com_10807_1col_10807_200
Systematic Research Review of Collaborative Assessment Methods
Aschieri F. (ORCID:0000-0002-1164-5926)
Aschieri, Filippo
van Emmerik, A. A. P.
Wibbelink, C. J. M.
Kamphuis, J. H.
collaborative assessment
psychological assessment
psychotherapy
psychotherapy outcome
Settore M-PSI/07 - PSICOLOGIA DINAMICA
Collaborative assessment methods (CAMs) involve working with clients during all phases of the assessment process, from goal definition to interpretation of the testing results to the recommendations and conclusions. In this article, we define CAMs, provide clinical examples, and then meta-analyze the published literature to assess their effectiveness on distal treatment outcomes. Our meta-analytic results indicate that CAMs have positive effects on three outcome domains: a moderate effect on treatment processes, a small-to-moderate effect on personal growth, and a small effect on symptom reduction. There is little research evidence on the immediate, in-session effects of CAMs. We include diversity considerations, training implications. and therapeutic practices grounded in this research evidence.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/240496
10.1037/pst0000477
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85158166222
info:eu-repo/semantics/altIdentifier/pmid/36972083
info:eu-repo/semantics/altIdentifier/wos/WOS:000958652600001
eng
issue:Advance online publication.
firstpage:1
lastpage:12
numberofpages:12
issueyear:2023
journal:PSYCHOTHERAPY
American Psychological Association
oai:publicatt.unicatt.it:10807/2459582024-03-17T21:32:39Zcom_10807_41com_10807_1col_10807_200
Multimodal therapy for synchronous bone oligometastatic NSCLC: The role of surgery
Congedo, Maria Teresa
Meacci, Elisa (ORCID:0000-0001-8424-3816)
Vita, Maria Letizia
Lococo, Filippo (ORCID:0000-0002-9383-5554)
D'Argento, Ettore
Margaritora, Stefano (ORCID:0000-0002-9796-760X)
Congedo, Maria Teresa
Nachira, Dania
Bertolaccini, Luca
Chiappetta, Marco
Zanfrini, Edoardo
Meacci, Elisa
Vita, Maria Letizia
Lococo, Filippo
D'Argento, Ettore
Spaggiari, Lorenzo
Margaritora, Stefano
bone metastases
lung surgery
oligometastatic NSCLC
oncological outcomes
radiotherapy
Settore MED/21 - CHIRURGIA TORACICA
Objectives The study aimed to assess the feasibility of radical surgical treatment for selected bone-oligometastatic non-small cell lung cancer (NSCLC) patients and to identify prognostic factors associated with survival. Materials and methods The clinical records of 27 patients with bone synchronous oligometastatic NSCLC were retrospectively analyzed. Results Thirteen (48.1%) bone metastases were treated by surgery and 14 (51.9%) by local radiotherapy. Eighteen (66.7%) patients underwent induction chemotherapy before lung surgery, and 3 (11.1%) concurrent radiotherapy. Pulmonary surgery was a major lung resection in 23 (85.2%) cases. Intraoperative and 30-days mortality was null. Only one major (ARDS) and 10 (37.04%) mild complications (like air leakage, arrhythmia, and mucus retention) were recorded. 1-year and 5-years OS from the diagnosis and 1-year, 3- years disease-free survival (DFS) were 96%, 38%, and 66%, 30%, respectively. After stepwise Cox regression analysis, local recurrence (p = 0.05) and metachronous metastases (p = 0.04) maintained their independent prognostic value as overall survival negative determinants. Nodal upstaging (p = 0.04) and nonsurgical treatment of bone lesion (p = 0.03) turned out to be independent risk factors for shorter DFS; the vertebral localization of bone metastases showed only a remarkable trend towards significance (p = 0.06) as a risk factor for a worse DFS. Conclusions In selected patients, surgical treatment of primary NSCLC and bone synchronous metastasis seems to be safe and feasible and rewarding survivals may be expected.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/245958
10.1002/jso.26773
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121333592
info:eu-repo/semantics/altIdentifier/pmid/34918785
info:eu-repo/semantics/altIdentifier/wos/WOS:000731055300001
eng
volume:125
issue:4
firstpage:782
lastpage:789
numberofpages:8
issueyear:2022
journal:JOURNAL OF SURGICAL ONCOLOGY
WILEY
oai:publicatt.unicatt.it:10807/2297692024-03-08T02:16:45Zcom_10807_41com_10807_1col_10807_200
Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA-C
Locatelli F. (ORCID:0000-0002-7976-3654)
Meazza, R.
Falco, M.
Canevali, P.
Loiacono, F.
Colomar-Carando, N.
Muntasell, A.
Rea, A.
Mingari, M. C.
Locatelli, Franco
Moretta, L.
Lopez-Botet, M.
Pende, D.
HLA-C
killer immunoglobulin-like receptors
KIR/KIR-ligand interaction
monoclonal antibodies
natural killer cells
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
The phenotypic identification of different NK cell subsets allows more in-depth characterization of KIR repertoire and function, which are of potential interest in KIR and disease association studies. KIR genes are highly polymorphic, but a great homology exists among the various sequences and few monoclonal antibodies (mAbs) specifically recognize a single KIR. This is the case of HP-DM1 which was demonstrated by analysis of cell transfectants and epitope mapping to be exclusively KIR2DL1-specific, covering all allotypes identified to date, except for KIR2DL1*022 and *020, and also to react with KIR2DS1*013. Here, we compared in immunofluorescence analyses the staining of HP-DM1 with other available mAbs to precisely identify KIR2DL1+ NK cells in potential donors for αβT/B-depleted haplo-HSCT, with known KIR genotype. HP-DM1 mAb was used in combination with EB6 or 11PB6 (anti-KIR2DL1/S1 and anti-KIR2DL3*005), 143211 (anti-KIR2DL1/S5), and HP-MA4 (anti-KIR2DL1/S1/S3/S5) mAbs, allowing the accurate identification of different KIR+ NK cell subsets. These phenotypic evaluations appeared useful to dissect the expression pattern of various KIR2D in NK cells from KIR2DL3*005+ individuals, particularly if KIR2DS1 is present. HP-DM1 mAb remarkably refined NK cell phenotyping of donors carrying KIR2DS5, either in the centromeric or telomeric region. Functional assays with KIR2DL1+/S1+/S5+ NK cells confirmed that only HP-DM1 exclusively reacts with KIR2DL1. Finally, we demonstrated that HP-DM1 mAb blocked KIR2DL1 recognition of C2+ HLA-C. Altogether, the data support that HP-DM1 is a unique reagent valuable for characterizing KIR+ NK cell subsets.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229769
10.1111/tan.14640
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131563979
info:eu-repo/semantics/altIdentifier/pmid/35439359
info:eu-repo/semantics/altIdentifier/wos/WOS:000795788900001
eng
volume:100
issue:2
firstpage:119
lastpage:132
numberofpages:14
issueyear:2022
journal:HLA
John Wiley and Sons Inc
oai:publicatt.unicatt.it:10807/2350902023-12-02T23:38:35Zcom_10807_41com_10807_1col_10807_200
Hydrogen adsorption study on nanostructured Ag–Rh films grown by supersonic cluster beam deposition
Cavaliere E. (ORCID:0000-0002-1934-6760)
Gavioli L. (ORCID:0000-0003-2782-7414)
Vega, F.
Fernandez, J.
Elgueta, S.
Cavaliere, Emanuele
Gavioli, Luca
Cabrera, A. L.
Ag Rh nanoparticle
hydrogen storage
ultrathin nanogranular film
supersonic cluster beam deposition
Settore FIS/03 - FISICA DELLA MATERIA
Settore FIS/01 - FISICA SPERIMENTALE
Following recent literature work, an interesting result on hydrogen sorption by Ag–Rh clusters was reported which do not follow the common understanding of hydrogen absorption in bulk alloys. Thus, nanostructured Ag–Rh films with a composition of 75% Ag–25% Rh were grown by supersonic cluster beam deposition onto microbalance quartz crystals in order to measure hydrogen absorption. The films were exposed to H2 gas to study hydrogen absorption at different partial pressure. The Ag–Rh films were then characterized by XPS and AFM. The Ag/Rh atomic ratio was found to be 75/25 by XPS. Surface roughness was determined by AFM to be 3 nm RMS in all the films. In disagreement with the quoted literature report, no hydrogen absorption was observed in our Ag–Rh films up to 5.3×103Pa of hydrogen pressure. The response of the balance was checked and validated by measuring hydrogen absorption on 10 and 100 nm Pd films. The hydrogen absorption by Pd yielded an atomic H/Pd ratio of ∼0.65 in agreement with our prior measurements.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/235090
10.1016/j.ijhydene.2023.01.225
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147384617
info:eu-repo/semantics/altIdentifier/wos/WOS:000998845100001
eng
issue:48
firstpage:17230
lastpage:17236
numberofpages:7
issueyear:2023
journal:INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
Elsevier Ltd
oai:publicatt.unicatt.it:10807/2196932023-07-28T11:56:10Zcom_10807_41com_10807_1col_10807_200
Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database
Mega, Andrea
Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Miele, Luca (ORCID:0000-0003-3464-0068)
Vitale, Alessandro
Svegliati-Baroni, Gianluca
Ortolani, Alessio
Cucco, Monica
Dalla Riva, Giulio V
Giannini, Edoardo G
Piscaglia, Fabio
Rapaccini, Gianludovico
Di Marco, Mariella
Caturelli, Eugenio
Zoli, Marco
Sacco, Rodolfo
Cabibbo, Giuseppe
Marra, Fabio
Mega, Andrea
Morisco, Filomena
Gasbarrini, Antonio
Foschi, Francesco Giuseppe
Missale, Gabriele
Masotto, Alberto
Nardone, Gerardo
Raimondo, Giovanni
Azzaroli, Francesco
Vidili, Gianpaolo
Oliveri, Filippo
Pelizzaro, Filippo
Ramirez Morales, Rafael
Cillo, Umberto
Trevisani, Franco
Miele, Luca
Marchesini, Giulio
Farinati, Fabio
hepatocellular carcinoma
nonalcoholic steatohepatitis
Settore MED/12 - GASTROENTEROLOGIA
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort. Methods We analysed 6882 consecutive patients with HCC enrolled from 2002 to 2019 by 23 Italian Liver Cancer centres to compare epidemiological and future trends in three subgroups: pure, single aetiology MAFLD (S-MAFLD); mixed aetiology MAFLD (metabolic and others, M-MAFLD); and non-MAFLD HCC. Results MAFLD was diagnosed in the majority of patients with HCC (68.4%). The proportion of both total MAFLD and S-MAFLD HCC significantly increased over time (from 50.4% and 3.6% in 2002-2003, to 77.3% and 28.9% in 2018-2019, respectively, p<0.001). In Italy S-MAFLD HCC is expected to overcome M-MAFLD HCC in about 6 years. Patients with S-MAFLD HCC were older, more frequently men and less frequently cirrhotic with clinically relevant portal hypertension and a surveillance-related diagnosis. They had more frequently large tumours and extrahepatic metastases. After weighting, and compared with patients with non-MAFLD, S-MAFLD and M-MAFLD HCC showed a significantly lower overall (p=0.026, p=0.004) and HCC-related (p<0.001, for both) risk of death. Patients with S-MAFLD HCC showed a significantly higher risk of non-HCC-related death (p=0.006). Conclusions The prevalence of MAFLD HCC in Italy is rapidly increasing to cover the majority of patients with HCC. Despite a less favourable cancer stage at diagnosis, patients with MAFLD HCC have a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/219693
10.1136/gutjnl-2021-324915
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137250091
info:eu-repo/semantics/altIdentifier/pmid/34933916
info:eu-repo/semantics/altIdentifier/wos/WOS:000733795700001
eng
volume:2021
issue:DICEMBRE
firstpage:N/A
lastpage:N/A
issueyear:2021
journal:EGUT
BMJ PUBLISHING GROUP
oai:publicatt.unicatt.it:10807/2487142024-03-15T05:10:29Zcom_10807_41com_10807_1col_10807_200
Il disagio del progresso. Note sul sentiment della crisi
Daniele Bruzzone (ORCID:0000-0002-2497-0277)
Bruzzone, Daniele
Progresso
Tonalità emotiva
Stimmung
Fenomenologia
Educazione
Settore M-PED/01 - PEDAGOGIA GENERALE E SOCIALE
The idea of progress, the main feature of Western civilization for centuries, was subtended by a complex mood – a sense of security combined with faith in reason and trust in the future – that appears in deep crisis nowadays. The society of uncertainty and weak reason, indeed, is characterized by a lack of feeling for the future and questions any perspective of cumulative and virtually unlimited growth. The phenomenology of affectivity shows that mood transformations disclose (or preclude) certain ways of experiencing and being in the world. An analysis of the Stimmung of our times is developed here, in order to understand the deeper motives of the malaise of progress and to sketch the clues of a new experience of the world, which perhaps can be only attained through this discomfort.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/248714
10.7347/spgs-01s-2023-49
ita
volume:1
issue:1 (Supplemento)
firstpage:263
lastpage:268
numberofpages:6
issueyear:2023
journal:CULTURA PEDAGOGICA E SCENARI EDUCATIVI
oai:publicatt.unicatt.it:10807/2444342023-07-21T22:48:26Zcom_10807_41com_10807_1col_10807_200
The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies
Locatelli, Franco (ORCID:0000-0002-7976-3654)
Fierabracci, Alessandra
Milillo, Annamaria
Locatelli, Franco
Fruci, Doriana
Autoimmunity etiopathogenesis
MHC class 1
Antigen processing
ERAPs
GWAS
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Autoimmune diseases represent a heterogeneous group of conditions whose incidence is increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors, aimed at finally improving prevention and treatment of these diseases. In the autoimmune process, immune responses are generated against self antigens presented by Major Histocompatibility Complex (MHC) class I on the cell surface. These peptide/MHC class I complexes are generated and assembled through MHC class I antigen processing and presentation machinery. In the endoplasmic reticulum (ER), aminopeptidases ERAP1 and ERAP2 display distinct trimming activity before antigenic peptides are loaded onto MHC class I molecules.The advent of new tools such as genome-wide association studies (GWAS) has provided evidence for new susceptibility loci and candidate genes playing a role in the autoimmune process for the recognized immune function of their transcripts. Genetic linkage has been discovered with MHC antigens and various autoimmune conditions. Recent GWAS showed the importance of ERAP1 and ERAP2 in several autoimmune diseases, including ankylosing spondylitis, insulin-dependent diabetes mellitus, psoriasis, multiple sclerosis, Crohn's disease.In this review, we first provide a general overview of ERAP1 and ERAP2 genes, their biological functions and their relevancy in autoimmunity. We then discuss the importance of GWAS and the case-control studies that confirm the relevancy of ERAP single-nucleotide polymorphism associations and their linkage with particular MHC class I haplotypes, supporting a putative functional role in the autoimmune process. (c) 2012 Elsevier B.V. All rights reserved.
2012
info:eu-repo/semantics/article
https://hdl.handle.net/10807/244434
10.1016/j.autrev.2012.04.007
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84870255603
info:eu-repo/semantics/altIdentifier/pmid/22575366
info:eu-repo/semantics/altIdentifier/wos/WOS:000313403500027
eng
volume:12
issue:2
firstpage:281
lastpage:288
numberofpages:8
issueyear:2012
journal:AUTOIMMUNITY REVIEWS
ELSEVIER SCIENCE BV
oai:publicatt.unicatt.it:10807/2295112024-03-18T18:03:57Zcom_10807_41com_10807_1col_10807_200
Rest/Stress Intradermal Lymphoscintigraphy for the Functional Imaging of the Lymphatic System
Visconti G. (ORCID:0000-0002-0041-5420)
Tarantino G.
Gentileschi S. (ORCID:0000-0001-9682-4706)
Salgarello M. (ORCID:0000-0003-4296-4214)
Tartaglione, G.
Ieria, F. P.
Visconti, Giuseppe
Bartoletti, R.
Tarantino, Giulio
Aloisi, D.
Gentileschi, Stefano
Salgarello, Marzia
exercise
intradermal injection
lymphatic system
lymphedema
lymphoscintigraphy
radionuclide imaging
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Purpose Lymphoscintigraphy is the criterion-standard method for diagnosing lymphedema, and there is no universally standardized imaging modality. In our center, we use a new approach: rest/stress intradermal lymphoscintigraphy. Methods We tested 231 consecutive patients with suspected lymphedema. All patients were studied after a complex physical therapy program to reduce edema. Two doses of Tc-99m-nanocolloid were injected intradermally. Two static planar scans were taken at rest following tracer injection. Next, patients performed an isotonic muscular exercise for 2 minutes followed by postexercise scans. Subsequently, a prolonged exercise was performed for 30 to 40 minutes, after which delayed scans were taken. Abnormal patterns were distinguished into minor or major findings, according to severity. Results We identified superficial lymphatic vessels and regional lymph nodes in approximately 80% of limbs. Deep vessels were visualized in 26% of limbs. Minor findings were reported in 22.7% of limbs examined, whereas major findings were reported in 53.2% of limbs. Conclusion We observed major findings including lymph stagnation, extravasation, or dermal backflow in a significantly higher percentage of limbs with secondary lymphedema than in primary. We also observed the deep lymphatic pathways in a significantly higher percentage of limbs with primary lymphedema. Intradermal radiotracer injection, combined with isotonic muscular exercise, may offer a better and faster imaging of lymphatic pathways, evaluating the effects of muscular exercise on lymphatic drainage. Based on the in-depth information of the lymphatic pathways provided by rest/stress intradermal lymphoscintigraphy, microsurgeons can obtain important functional information to perform supermicrosurgical lymphatic-venous anastomosis or vascularized lymph node transfer.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229511
10.1097/RLU.0000000000004422
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141891652
info:eu-repo/semantics/altIdentifier/pmid/36183418
info:eu-repo/semantics/altIdentifier/wos/WOS:000879547100019
eng
volume:47
issue:12
firstpage:1011
lastpage:1018
numberofpages:8
issueyear:2022
journal:CLINICAL NUCLEAR MEDICINE
LIPPINCOTT WILLIAMS & WILKINS
oai:publicatt.unicatt.it:10807/2291972024-03-23T22:46:40Zcom_10807_41com_10807_1col_10807_200
Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation
Locatelli F. (ORCID:0000-0002-7976-3654)
Dander, E.
De Lorenzo, P.
Bottazzi, B.
Quarello, P.
Vinci, P.
Balduzzi, A.
Masciocchi, F.
Bonanomi, S.
Cappuzzello, C.
Prunotto, G.
Pavan, F.
Pasqualini, F.
Sironi, M.
Cuccovillo, I.
Leone, R.
Salvatori, G.
Parma, M.
Terruzzi, E.
Pagni, F.
Locatelli, Franco
Mantovani, A.
Fagioli, F.
Biondi, A.
Garlanda, C.
Valsecchi, M. G.
Rovelli, A.
D'Amico, G.
Acute graft-versus-host disease
Biomarkers
Hematology
Immune response
Immunity
Immunology and microbiology section
Pediatric haematopoietic stem cell transplantation
Pentraxin 3 (PTX3)
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Acute Graft-versus-Host Disease (GvHD) remains a major complication of allogeneic haematopoietic stem cell transplantation, with a significant proportion of patients failing to respond to first-line systemic corticosteroids. Reliable biomarkers predicting disease severity and response to treatment are warranted to improve its management. Thus, we sought to determine whether pentraxin 3 (PTX3), an acutephase protein produced locally at the site of inflammation, could represent a novel acute GvHD biomarker. Using a murine model of the disease, we found increased PTX3 plasma levels after irradiation and at GvHD onset. Similarly, plasma PTX3 was enhanced in 115 pediatric patients on day of transplantation, likely due to conditioning, and at GvHD onset in patients experiencing clinical symptoms of the disease. PTX3 was also found increased in skin and colon biopsies from patients with active disease. Furthermore, PTX3 plasma levels at GvHD onset were predictive of disease outcome since they resulted significantly higher in both severe and therapyunresponsive patients. Multiple injections of rhPTX3 in the murine model of GvHD did not influence the disease course. Taken together, our results indicate that PTX3 constitutes a biomarker of GvHD severity and therapy response useful to tailor treatment intensity according to early risk-stratification of GvHD patients.
2016
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229197
10.18632/oncotarget.13488
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85004098314
info:eu-repo/semantics/altIdentifier/pmid/27893415
info:eu-repo/semantics/altIdentifier/wos/WOS:000391352800017
eng
volume:7
issue:50
firstpage:82123
lastpage:82138
numberofpages:16
issueyear:2016
journal:ONCOTARGET
Impact Journals LLC
oai:publicatt.unicatt.it:10807/2310092023-03-29T14:35:09Zcom_10807_41com_10807_1col_10807_200
«Prendiamoci cura di noi»: un progetto di supervisione online con le assistenti sociali italiane durante l’emergenza sanitaria COVID-19
Panciroli Chiara (ORCID:0000-0003-4096-6304)
Panciroli, Chiara
lavoro sociale
supervisione
Relational Social Work
emergenza Covid-19
servizi sociali
Settore SPS/07 - SOCIOLOGIA GENERALE
The social worker is a professional that works in emergency «by definition» because the challenges that social workers everyday face are characterized by a high rate of frenzy, complexity and multidimensionality. The level of complexity inherent in the professional practice is further amplified by the organizational context and the system of social policies. However, the direct and indirect consequences of the health emergency SARS COV 2 have placed the Social Services in the face of unprecedented challenges in which the practitioners have had to make enormous operational and personal efforts.
The article presents the findings of a research carried out beginning from a project pro- moted and financed by the Italian Association of Social Workers with the aim to offer a space of supervision to the social workers operating on the national territory during the pandemic COVID-19. The project resulted in the creation of 5 online supervision groups in which 37 social workers participated from different parts of Italy. The supervision pro- cess was monitored and studied by the Relational Social Work Research Center through the analysis of the diaries held by professionals who facilitated the supervision meetings and a focus group carried out at the end of the project. The research has highlighted how the supervision project has offered participants opportunities for support and advice for the management of complex situations, mutual emotional support, contrast to burnout, development of networks for future collaborations.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231009
10.7389/104620
ita
volume:2022
issue:2
firstpage:289
lastpage:310
numberofpages:22
issueyear:2022
journal:POLITICHE SOCIALI
oai:publicatt.unicatt.it:10807/2309872023-03-30T05:04:41Zcom_10807_41com_10807_1col_10807_200
Parapharyngeal Space Tumors: Our Experience
Jacopo Galli (ORCID:0000-0001-6353-6249)
Rolando Rolesi
Alessandro Pedicelli (ORCID:0000-0002-2558-8838)
Francesco Bussu (ORCID:0000-0001-6261-2772)
Emanuele Scarano (ORCID:0000-0003-2570-1121)
Galli, Jacopo
Rolesi, Rolando
Gallus, Roberto
Seccia, Annalisa
Pedicelli, Alessandro
Bussu, Francesco
Scarano, Emanuele
Contour
EVOH
SQUID12
para-pharyngeal space
transoral surgery
Settore MED/31 - OTORINOLARINGOIATRIA
Para-pharyngeal space (PPS) tumors include an heterogeneous group of neoplasms, accounting for approximatively 0.5-1.5% of all head and neck tumors. Management of these neoplasms requires a careful diagnostic workout and an appropriate surgical approach to obtain good outcomes associated with minimal aesthetic drawbacks. In this study we investigated clinical onset, histologic features, surgical treatment outcomes, peri operative complications and follow up of 98 patients treated for PPS tumors in our Centre between 2002 and 2021. Furthermore, we reviewed our preliminary experience of preoperative embolization of hyper vascular PPS tumors trough SQUID12, an ethylene vinyl alcohol copolymers (EVOH) which exhibits many advantages over other embolic agents, due to its better devascularization rate and lower risk of systemic complications. Our data support the hypothesis that transoral surgery scenario should be significantly revised, as it could represent a valid treatment for tumors located in lower and prestyloyd portion of PPS. Moreover, SQUID12, a novel embolization agent, may be a very promising choice for PPS hyper vascularized tumors, ensuring higher devascularization rate, safer procedures and lower risk of systemic dispersion compared to traditional Contour treatment.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/230987
eng
issue:feb
firstpage:283
lastpage:283
numberofpages:1
issueyear:2023
journal:JOURNAL OF PERSONALIZED MEDICINE
oai:publicatt.unicatt.it:10807/2295162024-03-08T02:16:47Zcom_10807_41com_10807_1col_10807_200
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention
Locatelli F. (ORCID:0000-0002-7976-3654)
Lanzillotta, C.
Zuliani, I.
Tramutola, A.
Barone, E.
Blarzino, C.
Folgiero, V.
Caforio, M.
Valentini, D.
Villani, A.
Locatelli, Franco
Butterfield, D. A.
Head, E.
Perluigi, M.
Abisambra, J. F.
Di Domenico, F.
Down syndrome
Nrf2
PERK
Protein translation
Unfolded protein response
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
A major challenge in neurobiology is the identification of the mechanisms by which protein misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant protein conformers aggregate into pathological inclusions, present the chronic activation of the PERK branch of the unfolded protein response. The adaptive effects of the PERK pathway include reduction of translation by transient inhibition of eIF2α and antioxidant protein production via induction of Nrf2 transcription factor. In contrast, PERK prolonged activation leads to sustained reduction in protein synthesis and induction of cell death pathways. To further investigate the role of the PERK pathway in neurodegenerative disorders, we focused on Down syndrome (DS), in which aging confers a high risk of Alzheimer disease (AD). By investigating human DS frontal cortices, we found early and sustained PERK activation associated with the induction of eIF2α and ATF4 downstream signals. We also observed that the Nrf2 response is uncoupled from PERK and its antioxidant effects are repressed in a mechanism implicating the transcription repressor Bach1. The pharmacological inhibition of PERK in DS mice reduced eIF2α-related translational repression and promoted Nrf2 nuclear translocation, favoring the rescue of Nrf2/Bach1 imbalance. The further analysis of peripheral cells from living DS individuals provided strong support of the pathological link between PERK and trisomy 21. Our results suggest that failure to regulate the PERK pathway is a peculiar characteristic of DS pathology and it may represent an essential step to promote cellular dysfunction, which actively contributes in the brain to the early development of AD.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229516
10.1016/j.pneurobio.2020.101892
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85089501564
info:eu-repo/semantics/altIdentifier/pmid/32795489
info:eu-repo/semantics/altIdentifier/wos/WOS:000604785900004
eng
volume:196
issue:196
firstpage:1
lastpage:17
numberofpages:17
issueyear:2021
journal:PROGRESS IN NEUROBIOLOGY
Elsevier Ltd
oai:publicatt.unicatt.it:10807/2212452023-06-14T00:57:32Zcom_10807_41com_10807_1col_10807_200
Pains, guns and moves: The effect of the U.S. opioid epidemic on Mexican migration
Marco Le Moglie (ORCID:0000-0003-3123-9818)
Daniele, Gianmarco
Le Moglie, Marco
Masera, Federico
Mexico, Opioid epidemics, Drug cartels
Settore SECS-P/01 - ECONOMIA POLITICA
In this paper, we study how a positive economic shock to an illicit industry might foster migration. In 2010, a series of reforms to the U.S. health care system resulted in a shift in demand from legal opiates to heroin. This demand shock had considerable effects on Mexico, the main supplier of heroin consumed in the United States. We exploit variation in potential opium production at the municipal level in a difference-in-differences (DID) framework, which compares Mexican municipalities with different amounts of opium-suitable land before and after 2010. We find that people fled out of municipalities more suitable for opium production, many to areas close to the U.S. border and into the United States. This is due to the increase in violence and conflicts, as municipalities more suitable for opium became highly valuable to drug cartels. Overall, almost 95,000 people migrate within Mexico and 22,000 emigrate to the United States.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/221245
10.1016/j.jdeveco.2022.102983
eng
volume:160
issue:January
firstpage:N/A
lastpage:N/A
issueyear:2023
journal:JOURNAL OF DEVELOPMENT ECONOMICS
oai:publicatt.unicatt.it:10807/2612242024-01-28T01:11:40Zcom_10807_41com_10807_1col_10807_209
Surgery after induction chemo or immunotherapy for locally advanced NSCLC
Lococo, Filippo (ORCID:0000-0002-9383-5554)
Sassorossi, Carolina
Vita, Emanuele
Martino, Antonella
Nachira, Dania (ORCID:0000-0003-2937-9678)
Cesario, Alfredo (ORCID:0000-0003-4687-0709)
Trisolini, Rocco
Bria, Emilio (ORCID:0000-0002-2333-704X)
Margaritora, Stefano (ORCID:0000-0002-9796-760X)
Lococo, Filippo
Sassorossi, Carolina
Mazzarella, Ciro
Vita, Emanuele
Leoncini, Fausto
Martino, Antonella
Nachira, Dania
Chiappetta, Marco
Cesario, Alfredo
Trisolini, Rocco
Bria, Emilio
Margaritora, Stefano
Lung cancer
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
none
2020
info:eu-repo/semantics/article
https://hdl.handle.net/10807/261224
10.21037/ccts-20-78
eng
volume:2
issue:2020
firstpage:1
lastpage:6
numberofpages:6
issueyear:2020
journal:CURRENT CHALLENGES IN THORACIC SURGERY
oai:publicatt.unicatt.it:10807/2291102024-03-15T18:28:32Zcom_10807_41com_10807_1col_10807_200
Proteomic Analysis of Neuroblastoma-Derived Exosomes: New Insights into a Metastatic Signature
Locatelli F. (ORCID:0000-0002-7976-3654)
Colletti, M.
Petretto, A.
Galardi, A.
Di Paolo, V.
Tomao, L.
Lavarello, C.
Inglese, E.
Bruschi, M.
Lopez, A. A.
Pascucci, L.
Geoerger, B.
Peinado, H.
Locatelli, Franco
Di Giannatale, A.
cell biology
exosomes
metastasis
neuroblastoma
signature
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. Around 70% of patients with metastatic disease at diagnosis present bone-marrow infiltration, which is considered a marker of poor outcome; however, the mechanism underlying this specific tropism has to be elucidated. Tumor-derived exosomes may support metastatic progression in several tumors by interacting with the microenvironment, and may serve as tumor biomarkers. The main objective of this study is to identify an exosomal signature associated with NB metastatic bone-marrow dissemination. Therefore, the proteomic cargo of exosomes isolated from NB cell lines derived from primary tumor and bone-marrow metastasis is characterized. The comparison among exosomal proteins show 15 proteins exclusively present in primary tumor-derived exosomes, mainly involved in neuronal development, and 6 proteins in metastasis-derived exosomes related to cancer progression. Significant proteins obtain with statistical analysis performed between the two groups, reveal that primary tumor exosomes contain a higher level of proteins involved in extra-cellular matrix (ECM) assembly and adhesion, as well as in neuronal development. Exosomes isolated from bone-marrow metastasis exhibit proteins involved in ameboidal cell migration and mitochondrial activity. This work suggests that proteomic profiling of NB-derived exosomes reflects the tumor stage and may be considered as potential tumor biomarker.
2017
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229110
10.1002/pmic.201600430
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85038411874
info:eu-repo/semantics/altIdentifier/pmid/28722341
info:eu-repo/semantics/altIdentifier/wos/WOS:000418420500004
eng
volume:17
issue:23-24
firstpage:1
lastpage:11
numberofpages:11
issueyear:2017
journal:PROTEOMICS
Wiley-VCH Verlag
oai:publicatt.unicatt.it:10807/2218912023-06-21T11:14:19Zcom_10807_41com_10807_1col_10807_200
Physicians' vs patients' global assessments of disease activity in rheumatology and musculoskeletal trials: A meta-research project with focus on reasons for discrepancies
D'Agostino, Maria-Antonietta (ORCID:0000-0002-5347-0060)
Lynæs, Christian
Lynæs, Maria
Simon, Lee S
Tugwell, Peter
D'Agostino, Maria Antonietta
Strand, Vibeke
Juhl, Carsten B
Nielsen, Sabrina M
De Witt, Maarten
Beaton, Dorca
Maxwell, Lara J
Meara, Alexa S
Christensen, Robin
disease activity, rheumatology, musculoskeletal trials, discrepancies
Settore MED/16 - REUMATOLOGIA
Background: In most rheumatic and musculoskeletal diseases (RMDs), global assessments of disease activity by physicians and patients are 'anchor outcomes' in therapeutic trials evaluating whether a treatment is effective. Objectives: To compare physicians' vs patients' global assessments of disease activity in RMD trials and explore reasons for discrepancies between them. Methods: Eligible trials were sampled from systematic reviews of treatments for RMDs by using the Cochrane database of systematic reviews (i.e., reviews from the Cochrane Musculoskeletal Group, [CMSG]). Randomized controlled trials (RCTs) of interventions for RMDs were eligible if they reported quantitative analyses of both physicians acute accent and patients acute accent global assessments at the same time point for the comparison of the same experimental intervention against the same comparator (i.e., placebo, no treatment, or other treatment). We accepted data from trial comparisons for each type of outcome, regardless of the type of intervention and type of RMD within the CMSG. Using mixed-effects meta -regression models, we assigned the dependent variable as the ratio of odds ratios (ROR) of global change with the experimental intervention, versus the control comparator. An ROR > 1 would indicate that physicians rated the experimental intervention more favorable than their patients did. Results: We were able to estimate the ROR (data from both physicians' and patients' global assessments) across 70 trials (116 randomized comparisons) in 7 diseases (ankylosing spondylitis, fibromyalgia, psoriatic arthritis, osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, and gout). The combined ROR across all effectiveness comparisons were rated significantly in favor of the intervention by physicians: ROR=1.15 CI 95% (1.07 to 1.23). This combined ROR was based on a substantial heterogeneity across comparisons (I2=89.1%). Across all the stratified analyses, the type of the RMD was an informative reason for discrepancies, with a statistically significant ROR in rheumatoid arthritis ROR=1.33, CI 95% (1.13 to 1.56), unlike the ROR in all other conditions (ROR=1.04, CI 95% (0.95-1.14). Conclusion: In comparative effectiveness research on rheumatology, physicians' global assessments of disease activity, surprisingly, are more in favor of the experimental interventions than are those of the patients.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/221891
10.1016/j.semarthrit.2022.152074
info:eu-repo/semantics/altIdentifier/pmid/35921746
info:eu-repo/semantics/altIdentifier/wos/WOS:000849117700001
eng
volume:56
issue:October
firstpage:152074
lastpage:N/A
issueyear:2022
journal:SEMINARS IN ARTHRITIS AND RHEUMATISM
W B SAUNDERS CO-ELSEVIER INC
oai:publicatt.unicatt.it:10807/2577952023-12-02T23:38:36Zcom_10807_41com_10807_1col_10807_200
Review and Alignment of Domain-Level Ontologies for Materials Science
Pozzi A. (ORCID:0000-0002-9808-5123)
Toti D. (ORCID:0000-0002-9668-6961)
De Baas, A.
Nostro, P. D.
Friis, J.
Ghedini, E.
Goldbeck, G.
Paponetti, I. M.
Pozzi, Andrea
Sarkar, A.
Yang, L.
Zaccarini, F. A.
Toti, Daniele
alignment
bridge concepts
data
domain-level ontology
harmonization
materials characterization
materials modeling
materials science
Ontology
standardization
top-level ontology
Settore ING-INF/05 - SISTEMI DI ELABORAZIONE DELLE INFORMAZIONI
The growing complexity and interdisciplinary nature of Materials Science research demand efficient data management and exchange through structured knowledge representation. Domain-Level Ontologies (DLOs) for Materials Science have emerged as a valuable tool for describing materials properties, processes, and structures, enabling effective data integration, interoperability, and knowledge discovery. However, the harmonization of DLOs, and, more generally, the establishment of fully interoperable multi-level ecosystems, remains a challenge due to various factors, including the diverse landscape of existing ontologies. This work provides, for the first time in literature, a comprehensive overview of the state-of-the-art of DLOs for Materials Science, reviewing more than 40 DLOs and highlighting their main features and purposes. Furthermore, an alignment methodology including both manual and automated steps, making use of Top-Level Ontologies' (TLO) capability of promoting interoperability, and revolving around the engineering of FAIR standalone entities acting as minimal data pipelines ('bridge concepts'), is presented. A proof of concept is also provided. The primary aspiration of this undertaking is to make a meaningful contribution towards the establishment of a unified ontology framework for Materials Science, facilitating more effective data integration and fostering interoperability across Materials Science subdomains.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/257795
10.1109/ACCESS.2023.3327725
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85176397131
eng
volume:11
issue:N/A
firstpage:120372
lastpage:120401
numberofpages:30
issueyear:2023
journal:IEEE ACCESS
Institute of Electrical and Electronics Engineers Inc.
oai:publicatt.unicatt.it:10807/2528142024-02-06T02:43:09Zcom_10807_41com_10807_1col_10807_200
L’impatto delle Medical Humanities nella formazione delle professioni sanitarie e nelle pratiche di cura. una revisione narrativa
Lombi L. (ORCID:0000-0002-8486-1021)
Lombi, Linda
Lombardi, L.
Medical Humanities
Empatia clinica
Professionisti sanitari
Valutazione d'impatto
Settore SPS/07 - SOCIOLOGIA GENERALE
In the international arena, there is a broad debate about the importance of including Medical
Humanities in the education of health professionals. On the one hand a large part of the available
literature highlights the several benefits of the impact of these disciplines on the competence
and skills of doctors and other health professionals, which are deemed useful in improving their care
practices. On the other hand, some scholars complain that these studies are not rigorous enough, and
that the evidence they provide is fragmented and limited. This article, based on a narrative review,
gives an account of this debate, highlighting the different theoretical-epistemological approaches
that support the discussion, the methodological weaknesses and the main findings of the studies.
In the conclusion, some suggestions for future research are provided and it is recommended that
an integrative approach be adopted, both from a theoretical-epistemological and a methodological
point of view: this will make it possible to assess the outcomes of Medical Humanities for health
professionals and care practices.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/252814
https://doi.org/10.26350/000309_000173
ita
issue:Special issue
firstpage:11
lastpage:27
numberofpages:17
issueyear:2023
journal:STUDI DI SOCIOLOGIA
oai:publicatt.unicatt.it:10807/2297472023-03-25T17:30:45Zcom_10807_41com_10807_1col_10807_209
ANGELA IDA VILLA - ANGELO COLOMBO, Editoriale, “R-EM. Rivista internazionale di Studi su Eugenio Montale”, n. 2-3, 2021-2022, pp. IX-XIV [= 6 pp.]
VILLA ANGELA IDA (ORCID:0000-0003-0679-334X)
Villa, Angela Ida
Colombo, Angelo
Arnaldo Di Benedetto, Giuseppe Farinelli, Luigi Blasucci (commemorazione dei componenti del Comitato scientifico della rivista montaliana "R-EM" deceduti nell'autunno del 2021)
Spiegazione del logo della rivista montaliana "R-EM" ideato da Angela Ida Villa e realizzato graficamente da Elena a Vitarelli
Decifrazione del Montale "che visse al 5%, non aumentate la dose"
L'Apocalisse nella misteriosa mitologia famigliare cimiteriale monterossina della famiglia Montale
"III Convegno internazionale di Studi su Eugenio Montale", Montale, Università Cattolica del Sacro Cuore, 18-19 maggio 2023, in modalità on line
Presentazione del numero 2-3, 2021-2022 di "R-EM. Rivista internazionale di studi su Eugenio Montale"
Settore L-FIL-LET/11 - LETTERATURA ITALIANA CONTEMPORANEA
ANGELA IDA VILLA - ANGELO COLOMBO, Editoriale, “R-EM. Rivista internazionale di Studi su Eugenio Montale”, n. 2-3, 2021-2022, pp. IX-XIV [= 6 pp.]
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229747
ita
volume:II-III
issue:2-3
firstpage:IX
lastpage:XIV
numberofpages:5
issueyear:2021-2022
journal:"R-EM. Rivista internazionale di Studi su Eugenio Montale"
oai:publicatt.unicatt.it:10807/2581942023-12-02T23:38:37Zcom_10807_41com_10807_1col_10807_200
Media Literacy al tempo degli “spettautori”: contrastare la povertà educativa digitale. Media Literacy at the time of the "prosumer": fighting digital educational poverty
Stefano Pasta (ORCID:0000-0002-7756-5427)
MIchele Marangi (ORCID:0000-0003-2013-5079)
Pasta, Stefano
Marangi, Michele
Povertà educativa digitale
competenza digitale
terzi spazi di apprendimento
cittadinanza onlife
Settore M-PED/03 - DIDATTICA E PEDAGOGIA SPECIALE
Settore M-PED/01 - PEDAGOGIA GENERALE E SOCIALE
Dal 2021 il CREMIT utilizza il nuovo costrutto di “povertà educativa digitale”, ampliando il concetto di “digital divide”. Si fa riferimento alla mancata acquisizione dei “nuovi alfabeti” per analizzare la produzione e la fruizione dei diversi contenuti da parte degli “spettautori” del social web. A partire dal progetto Connessioni Digitali (2021-24), si de- lineeranno l’impostazione teorica e le proposte di- dattiche per il contrasto della povertà educativa di- gitale. Le quattro newsroom (Scrittura online, Podcast, Digital Storytelling, Marketing sociale), attorno a cui è costruito il percorso, riflettono una concezione di competenza digitale dinamica, situa- ta e “incompiuta”, declinata nelle dimensioni criti- ca, estetica ed etica. Il progetto è infine analizzato secondo una Teoria del cambiamento tramite la Media Literacy, basata su accesso, consapevolezza, capacità e conseguenze.
Since 2021 CREMIT has been using the new construct of "digital educational poverty", expanding the concept of "digital divide". Reference is made to the failure to acquire the "new alphabets" to analyze the production and use of the different contents by the "spectators" of the social web. Starting from the Digital Connections project (2021-24), the theoretical approach and educational proposals for the fight against digital educational poverty will be outlined. The four newsrooms (Online Writing, Podcast, Digital Storytelling, Social Marketing), around which the itinerary is built, reflect a conception of dynamic, situated and "unfinished" digital competence, declined in the critical, aesthetic and ethical dimensions. Finally, the project is analyzed according to a Theory of Change through Media Literacy, based on access, awareness, capacity and consequences.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/258194
ita
issue:2
firstpage:307
lastpage:322
numberofpages:16
issueyear:XLI
journal:NUOVA SECONDARIA
oai:publicatt.unicatt.it:10807/2482352024-02-08T00:26:01Zcom_10807_41com_10807_1col_10807_200
A cultural training for the improvement of cognitive and affective Theory of Mind in people with Multiple Sclerosis: a pilot randomized controlled study
d’Arma, Alessia
Valle, Annalisa (ORCID:0000-0002-9852-6785)
Massaro, Davide (ORCID:0000-0002-4511-6897)
Isernia, Sara (ORCID:0000-0002-0849-3984)
Di Tella, Sonia (ORCID:0000-0002-2248-5120)
Marchetti, Antonella (ORCID:0000-0001-9985-0539)
D'Arma, Alessia
Valle, Annalisa
Massaro, Davide
Baglio, Gisella
Isernia, Sara
Di Tella, Sonia
Rovaris, Marco
Baglio, Francesca
Marchetti, Antonella
N/A
Settore M-PSI/04 - PSICOLOGIA DELLO SVILUPPO E PSICOLOGIA DELL'EDUCAZIONE
Theory of Mind (ToM), the ability to understand and attribute mental states to ourselves and others, could be impaired in Multiple Sclerosis (MS), a neurodegenerative disease affecting young adults. Considering that ToM is strictly connected to Quality of Life (QoL) in MS and that could enhance the social support network -which is particularly important for this population-, we aimed to design and implement a novel ToM rehabilitation training. To make the training as much ecological as possible, we have devised a protocol enhancing ToM through stimuli depicting real-world conditions (video-clips taken from cinema movies, literary fictions, and audio voices). We test training’s effect on both cognitive and affective components of ToM in a sample of 13 subjects, randomly assigned to the ToM training Group and to the Control Group. The following ToM tasks were administered: the Reading the Mind in the Eyes (RMET), the Strange Stories task, the Faux Pas Task and the False Belief First- and Second - Order Task (FB II and III order). We also administered a psycho-behavioral assessment through the Toronto Alexithymia Scale (TAS-20). Results show that our novel ToM training is useful in enhancing ToM abilities measured by the following tasks: the RMET (affective task, p = 0.015) and the FB II-order task (FB, cognitive task, p = 0.032). Our ToM training had also a significant effect on the total score of the TAS-20 Scale (p = 0.018) and on its “Difficulty Describing Feelings subscale” (p = 0.018), indicating a reduction of the alexithymia traits. Future works with larger samples could investigate the ToM training effectiveness in a more representative MS populations.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/248235
10.3389/fpsyg.2023.1198018
eng
volume:14
issue:N/A
firstpage:1
lastpage:10
numberofpages:10
issueyear:2023
journal:FRONTIERS IN PSYCHOLOGY
oai:publicatt.unicatt.it:10807/2310282023-03-29T20:50:36Zcom_10807_41com_10807_1col_10807_200
L’affascinante sezione aurea
Elisa Appiani (ORCID:0000-0001-9606-724X)
Laura Montagnoli (ORCID:0000-0001-7424-6538)
Appiani, Elisa
Baresi, Francesca
Montagnoli, Laura
Didattica della matematica
Sezione aurea
Flipped lesson
Settore MAT/04 - MATEMATICHE COMPLEMENTARI
Il contributo presenta un percorso interdisciplinare, ideato per studenti di una classe seconda della scuola secondaria di
primo grado, che si pone come obiettivo l’esplorazione, partendo dall’analisi del rettangolo aureo, delle molteplici possibilità del cosiddetto “numero d’oro” in matematica, in arte e nella
natura attraverso la flipped lesson.
2017
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231028
ita
volume:2016-2017
issue:Marzo
firstpage:82
lastpage:88
numberofpages:7
issueyear:2017
journal:SCUOLA E DIDATTICA
oai:publicatt.unicatt.it:10807/2284642024-03-06T04:39:05Zcom_10807_41com_10807_1col_10807_200
Characteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants
Locatelli F. (ORCID:0000-0002-7976-3654)
Cicconi, L.
Testi, A. M.
Montesinos, P.
Rego, E.
Zhu, H. H.
Takahashi, H.
Dworzak, M.
Estey, E.
Schwarer, A.
Esteve, J.
Annibali, O.
Castelli, R.
Mirabile, M.
Angelini, M.
Lazarevic, V.
Kumar, J.
Avvisati, G.
Gurnari, C.
Locatelli, Franco
Voso, M. T.
Sanz, M. A.
Lo-Coco, F.
Abla, O.
AML
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
NO ABSTRACT
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/228464
10.1038/s41408-021-00561-w
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85117489343
info:eu-repo/semantics/altIdentifier/pmid/34657125
info:eu-repo/semantics/altIdentifier/wos/WOS:000707700100001
eng
volume:11
issue:10
firstpage:1
lastpage:4
numberofpages:4
issueyear:2021
journal:BLOOD CANCER JOURNAL
Springer Nature
oai:publicatt.unicatt.it:10807/2314962023-03-31T08:15:13Zcom_10807_41com_10807_1col_10807_209
Foreword of the special issue: Nonlinear models and tools in economics, finance and social sciences
Radi D. (ORCID:0000-0001-7809-1166)
Tramontana F. (ORCID:0000-0002-7299-5524)
Gardini, L.
Radi, Davide
Tramontana, Fabio
Nonlinear Dynamics
Settore SECS-S/06 - METODI MATEMATICI DELL'ECONOMIA E DELLE SCIENZE ATTUARIALI E FINANZIARIE
The special issue on Nonlinear Economic Dynamics contains a selection of papers presented at the 11th International Conference on Nonlinear Economic Dynamics (NED) that took place on September 4–6, 2019, at the Kyiv School of Economics, Ukraine. Organized under the auspices of the Nonlinear Economic Dynamics Society, the NED conference is a biennial (odd-year) international meeting of scholars interested in the development of methods for studying nonlinear dynamical systems and in their applications in economics and social sciences. The aim of this meeting is to bring together different streams of the growing literature in this field and to stimulate a fruitful exchange between theoretical research and applications in economics.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231496
10.1016/j.cnsns.2022.107078
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147826831
info:eu-repo/semantics/altIdentifier/wos/WOS:000928121000001
eng
volume:119
issue:119
firstpage:107078
lastpage:107078
numberofpages:2
issueyear:2023
journal:COMMUNICATIONS IN NONLINEAR SCIENCE & NUMERICAL SIMULATION
Elsevier B.V.
oai:publicatt.unicatt.it:10807/2440462024-01-16T01:57:18Zcom_10807_41com_10807_1col_10807_200
Ancora sulla surrogazione di maternità. Ragioni del divieto e tecniche di tutela del nato
Renda Andrea (ORCID:0000-0001-9669-9730)
Renda, Andrea
Surrogazione di maternità
Adozione
Settore IUS/01 - DIRITTO PRIVATO
The essay deals with surrogacy, aiming to deepen in an integrated way both the reasons for the prohibition established by the Italian legal system (as well as by most European legal systems) and the legal instrument through which it is possible to protect the child born from surrogacy carried out abroad, from the point of view of the establishing of the relationship of filiation with those who have resorted to surrogacy and aspire to be recognized as the parents of the child. Preliminarily, the most common expressions used by the scholars (such as gestation for others, surrogacy of motherhood and intended parents) are submitted to criticism because they are misleading.
The reasons for the prohibition of surrogacy are identified in the protection of the dignity of the woman, as well as of the unborn and newborn child. Surrogacy treats the mother as a simple gestational carrier and thus degrades her to a mere means for the satisfaction of other people’s procreative purposes. At the same time, surrogacy treats the child as a product of the work of the woman’s body and as an object of delivery. Therefore, the prohibition has a constitutional foundation and expresses a principle of international public order.
This implies that the foreign birth certificate or the foreign judgement cannot be recognized in Italy limited to the part in which they attribute parenthood to the subject who has not a biological link with the child. The most appropriate way to protect the child is to apply the rule of article 279 of the civil code, in order to attribute him all the rights towards this subject, without attributing reciprocal rights to this subject towards the child. Nevertheless, since the decisions of the courts ignore this legal instrument and focus on the alternative between full transcription of the birth certificate and simple adoption (“adozione in casi particolari”), the essay discusses which of the two is the one less conflicting with the general principles of the system. Even though the application of simple adoption to the (heterosexual or homosexual) cohabitant of the biological parent would require an explicit legislative provision, this way seems less disruptive than the other one, which frustrates full adoption and is contradictory to the choice of the legal system to allow the contestation of maternity in case of supposition of childbirth.
Finally, arguments are advanced to justify the recognition of paternity of the subject who has a biological link with the child.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/244046
ita
issue:2
firstpage:281
lastpage:350
numberofpages:70
issueyear:2023
journal:EUROPA E DIRITTO PRIVATO
oai:publicatt.unicatt.it:10807/2509392024-03-09T20:13:53Zcom_10807_41com_10807_1col_10807_200
Colon capsule endoscopy to screen for colorectal neoplasia in those with family histories of colorectal cancer
Hassan C.
Spada C. (ORCID:0000-0002-5692-0960)
Parodi, A.
Vanbiervliet, G.
Hassan, Cesare
Hebuterne, X.
De Ceglie, A.
Filiberti, R. A.
Spada, Cristiano
Conio, M.
colorectal cancer
Settore MED/12 - GASTROENTEROLOGIA
Background and Aims: Colon capsule endoscopy (CCE) has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk people. Our aim was to prospectively assess the accuracy of CCE as a screening tool in first-degree relatives (FDRs) of people with CRC by using optical colonoscopy (OC) with segmental unblinding as the reference standard. Methods: Consecutive patients admitted with a CRC diagnosis (index cases) were prospectively evaluated and invited to contact their FDRs. Available FDRs were invited to undergo CCE and OC on the following day, with segmental unblinding of CCE results. Sensitivity, specificity, and predictive values/negative predictive values (PPV/NPV) of CCE were assessed for detecting patients with any polyp ≥6 mm and ≥10 mm. Results: A total of 177 FDRs (median age 57.0 years, 54.8% female) identified from 211 index cases were included. Both CCE and OC were completed in all the included FDRs. Overall, CCE identified 51 of 56 FDRs with polyps ≥6 mm (sensitivity 91%; 95% CI, 81-96) and correctly classified as negative 107 of 121 participants without lesions ≥6 mm (specificity 88%; 95% CI, 81-93). Per-patient positive and negative predictive values for ≥6 mm lesions were 78% (95% CI, 67-87) and 95% (95% CI, 90-98), respectively. CCE detected 24 of 27 patients with polyps ≥10 mm and correctly classified as negative 142 of 150 patients, corresponding to 89% sensitivity and 95% specificity. Post-CCE referral rates to colonoscopy were 37% and 18%, respectively. Conclusions: CCE is an accurate method to screen FDRs of patients with CRC and could be offered as an alternative to those who decline or are unfit for colonoscopy screening. (Clinical trial registration number: NCT01184781.)
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/250939
10.1016/j.gie.2017.05.023
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85024381255
info:eu-repo/semantics/altIdentifier/pmid/28554656
info:eu-repo/semantics/altIdentifier/wos/WOS:000425100000011
eng
volume:87
issue:3
firstpage:695
lastpage:704
numberofpages:10
issueyear:2018
journal:GASTROINTESTINAL ENDOSCOPY
Mosby Inc.
oai:publicatt.unicatt.it:10807/2256872023-06-21T13:30:17Zcom_10807_41com_10807_1col_10807_200
On a threshold descent method for quasi-equilibria
Bianchi Monica (ORCID:0000-0002-5296-3111)
Bianchi, Monica
Konnov, Igor
Pini, Rita
quasi-equilibrium problems
Brezis pseudomonotonicity
Threshold descendent method
Settore MAT/09 - RICERCA OPERATIVA
We describe a special class of quasi-equilibrium problems in metric spaces and proposea novel simple threshold descent method for solving these problems. Due tothe framework, the convergence of the method cannot be established with the usual convexity or generalized convexity assumptions. Under mild conditions, the iterative procedure gives solutions of the quasi-equilibrium problem. We apply this method to scalar and vector generalized quasi-equilibrium problems and to some classes of
relative optimization problems.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/225687
10.1007/s11590-023-01978-x
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147346260
info:eu-repo/semantics/altIdentifier/wos/WOS:000925915000001
eng
volume:2023
issue:N/A
firstpage:N/A
lastpage:N/A
issueyear:2023
journal:OPTIMIZATION LETTERS
oai:publicatt.unicatt.it:10807/2308282023-06-21T16:32:10Zcom_10807_41com_10807_1col_10807_200
Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease
Del Vecchio, Livio Enrico
Fiorani, Marcello
Porcari, Serena
Mele, Maria Cristina (ORCID:0000-0003-0153-5819)
Pizzoferrato, Marco
Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Cammarota, Giovanni (ORCID:0000-0002-3626-6148)
Ianiro, Gianluca (ORCID:0000-0002-8318-0515)
Del Vecchio, Livio Enrico
Fiorani, Marcello
Tohumcu, Ege
Bibbò, Stefano
Porcari, Serena
Mele, Maria Cristina
Pizzoferrato, Marco
Gasbarrini, Antonio
Cammarota, Giovanni
Ianiro, Gianluca
Clostridioides difficile
Crohn’s disease
fecal microbiota transplantation
inflammatory bowel disease
ulcerative colitis
Settore MED/09 - MEDICINA INTERNA
Clostridioides difficile infection (CDI) and inflammatory bowel disease (IBD) are two pathologies that share a bidirectional causal nexus, as CDI is known to have an aggravating effect on IBD and IBD is a known risk factor for CDI. The colonic involvement in IBD not only renders the host more prone to an initial CDI development but also to further recurrences. Furthermore, IBD flares, which are predominantly set off by a CDI, not only create a need for therapy escalation but also prolong hospital stay. For these reasons, adequate and comprehensive management of CDI is of paramount importance in patients with IBD. Microbiological diagnosis, correct evaluation of clinical status, and consideration of different treatment options (from antibiotics and fecal microbiota transplantation to monoclonal antibodies) carry pivotal importance. Thus, the aim of this article is to review the risk factors, diagnosis, and management of CDI in patients with IBD.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/230828
10.3390/microorganisms10071315
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133020673
info:eu-repo/semantics/altIdentifier/pmid/35889034
info:eu-repo/semantics/altIdentifier/wos/WOS:000833103000001
eng
volume:10
issue:7
firstpage:1315
lastpage:N/A
issueyear:N/A
journal:MICROORGANISMS
MDPI
oai:publicatt.unicatt.it:10807/2300832024-03-12T14:02:34Zcom_10807_41com_10807_1col_10807_200
Corrigendum : Targeted NGS platforms for genetic screening and gene discovery in primary immunodeficiencies (Frontiers in Immunology (2019) 10 (316) DOI: 10.3389/fimmu.2019.00316)
Locatelli F. (ORCID:0000-0002-7976-3654)
Cifaldi, C.
Brigida, I.
Barzaghi, F.
Zoccolillo, M.
Ferradini, V.
Petricone, D.
Cicalese, M. P.
Lazarevic, D.
Cittaro, D.
Omrani, M.
Attardi, E.
Conti, F.
Scarselli, A.
Chiriaco, M.
Cesare, S. D.
Licciardi, F.
Davide, M.
Ferrua, F.
Canessa, C.
Pignata, C.
Giliani, S.
Ferrari, S.
Fousteri, G.
Barera, G.
Merli, P.
Palma, P.
Cesaro, S.
Gattorno, M.
Trizzino, A.
Moschese, V.
Chini, L.
Villa, A.
Azzari, C.
Finocchi, A.
Locatelli, Franco
Rossi, P.
Sangiuolo, F.
Aiuti, A.
Cancrini, C.
Di Matteo, G.
primary immunodeficiencies
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
A Corrigendum on Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies by Cifaldi, C., Brigida, I., Barzaghi, F., Zoccolillo, M., Ferradini, V., Petricone, D., et al. (2019). Front. Immunol. 10:316. doi: 10.3389/fimmu.2019.00316 In the published article, there was an error in affiliation “18.” Instead of “Pediatric and Rheumatology Unit, Giannina Gaslini Institute, Genoa, Italy,” it should be “Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
2019
info:eu-repo/semantics/article
https://hdl.handle.net/10807/230083
10.3389/fimmu.2019.01184
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85068463712
info:eu-repo/semantics/altIdentifier/pmid/31214169
info:eu-repo/semantics/altIdentifier/wos/WOS:000470172900002
eng
volume:10
issue:MAY
firstpage:1
lastpage:2
numberofpages:2
issueyear:2019
journal:FRONTIERS IN IMMUNOLOGY
Frontiers Media S.A.
oai:publicatt.unicatt.it:10807/2286072024-03-20T17:48:03Zcom_10807_41com_10807_1col_10807_200
Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias
Locatelli F. (ORCID:0000-0002-7976-3654)
Pietra, G.
Vitale, C.
Pende, D.
Bertaina, A.
Moretta, F.
Falco, M.
Vacca, P.
Montaldo, E.
Cantoni, C.
Mingari, M. C.
Moretta, A.
Locatelli, Franco
Moretta, L.
Acute leukemias
Hematopoietic stem cell transplantation
Immunotherapy
Innate lymphoid cells
NK cells
Tumor microenvironment
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
It is well established that natural killer (NK) cells play an important role in the immunity against cancer, while the involvement of other recently identified, NK-related innate lymphoid cells is still poorly defined. In the haploidentical hematopoietic stem cell transplantation for the therapy of high-risk leukemias, NK cells have been shown to exert a key role in killing leukemic blasts residual after conditioning. While the clinical results in the cure of leukemias are excellent, the exploitation of NK cells in the therapy of solid tumors is still limited and unsatisfactory. In solid tumors, NK cell function may be inhibited via different mechanisms, occurring primarily at the tumor site. The cellular interactions in the tumor microenvironment involve tumor cells, stromal cells and resident or recruited leukocytes and may favor tumor evasion from the host’s defenses. In this context, a number of cytokines, growth factors and enzymes synthesized by tumor cells, stromal cells, suppressive/regulatory myeloid and lymphoid cells may substantially impair the function of different tumor-reactive effector cells, including NK cells. The identification and characterization of such mechanisms may offer clues for the development of new immunotherapeutic strategies to restore effective anti-tumor responses. In order to harness NK cell-based immunotherapies, several approaches have been proposed, including reinforcement of NK cell cytotoxicity by means of specific cytokines, antibodies or drugs. These new tools may improve NK cell function and/or increase tumor susceptibility to NK-mediated killing. Hence, the integration of NK-based immunotherapies with conventional anti-tumor therapies may increase chances of successful cancer treatment.
2016
info:eu-repo/semantics/article
https://hdl.handle.net/10807/228607
10.1007/s00262-015-1744-y
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84939641003
info:eu-repo/semantics/altIdentifier/pmid/26289090
info:eu-repo/semantics/altIdentifier/wos/WOS:000373952700010
eng
volume:65
issue:4
firstpage:465
lastpage:476
numberofpages:12
issueyear:2016
journal:CANCER IMMUNOLOGY, IMMUNOTHERAPY
Springer Science and Business Media Deutschland GmbH
oai:publicatt.unicatt.it:10807/2228882024-03-23T18:49:39Zcom_10807_41com_10807_1col_10807_200
Clustering coefficients as measures of the complex interactions in a directed weighted multilayer network
Gian Paolo Clemente (ORCID:0000-0001-6795-4595)
Bartesaghi, Paolo
Clemente, Gian Paolo
Grassi, Rosanna
Multilayer network
Complex systems
Clustering coefficient
World trade
Settore SECS-S/06 - METODI MATEMATICI DELL'ECONOMIA E DELLE SCIENZE ATTUARIALI E FINANZIARIE
In this paper, we provide novel definitions of clustering coefficient for weighted and directed multilayer networks. We extend in the multilayer theoretical context the clustering coefficients proposed in the literature for weighted directed monoplex networks.
We quantify how deeply a node is involved in a cohesive structure focusing on a single node, a single layer or the entire system, respectively. The coefficients convey several characteristics inherent to the complex topology of the multilayer network. We test their effectiveness applying them to a particularly complex structure such as the international
trade network. The trade data integrate different aspects and they can be described by a directed and weighted multilayer network, where each layer represents import and export relationships between countries for a given sector. The proposed coefficients find successful application in describing the interrelations of the trade network, allowing to disentangle the effects of countries and sectors and jointly consider the interactions between them.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/222888
10.1016/j.physa.2022.128413
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144628694
eng
volume:610
issue:N/A
firstpage:N/A
lastpage:N/A
issueyear:N/A
journal:PHYSICA. A
oai:publicatt.unicatt.it:10807/2599562024-03-19T18:21:14Zcom_10807_41com_10807_1col_10807_200
Gender segregation in higher education: an empirical test of seven explanations
Assirelli G. (ORCID:0009-0007-7594-7206)
Barone, C.
Assirelli, Giulia
Field of study choice
Gender segregation
Higher education
Settore SPS/07 - SOCIOLOGIA GENERALE
Settore SPS/08 - SOCIOLOGIA DEI PROCESSI CULTURALI E COMUNICATIVI
Settore SPS/09 - SOCIOLOGIA DEI PROCESSI ECONOMICI E DEL LAVORO
Gender segregation in higher education (GSHE) is recognized as a key factor to explain the persistence of gender inequalities in the labor market despite the reversal of gender gap in educational attainment. Women are systematically overrepresented in fields of study, such as social sciences and the humanities, which offer relatively poor labor market prospects; at the same time, they are underrepresented in fields that perform above the average, as engineering and ICT. Several explanations for GSHE have been proposed in the literature, but their explanatory power has to be assessed yet. Using a rich longitudinal dataset on a recent cohort of Italian upper secondary school leavers, in this paper we jointly test seven potential mechanisms for GSHE. Our results show that rational choice explanations—such as skill-based explanations and gender differences in career preferences—fail to account for GSHE. On the contrary, expressive motivations related to preferences for school subjects and for specific occupations are found to mediate to a significant extent GSHE. However, our most important result concerns the key role of curricular track choice at upper secondary level which, alone, mediates two third of the gender difference in access to the humanities and social sciences and one third of the gender difference in access to engineering and ICT.
2020
info:eu-repo/semantics/article
https://hdl.handle.net/10807/259956
10.1007/s10734-019-00396-2
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072227876
info:eu-repo/semantics/altIdentifier/wos/WOS:000511894900004
eng
volume:79
issue:N/A
firstpage:55
lastpage:78
numberofpages:24
issueyear:2020
journal:HIGHER EDUCATION
Springer
oai:publicatt.unicatt.it:10807/2508162024-03-20T02:01:38Zcom_10807_41com_10807_1col_10807_200
Nonendoscopic transnasal placement of a wireless capsule for esophageal pH monitoring: Feasibility, safety, and efficacy of a manometry-guided procedure
Spada C. (ORCID:0000-0002-5692-0960)
Familiari P. (ORCID:0000-0002-5181-2928)
Tringali A. (ORCID:0000-0002-9614-3449)
Costamagna G. (ORCID:0000-0002-8100-2731)
Marchese, M.
Spada, Cristiano
Iacopini, F.
Familiari, Pietro
Shah, S. G.
Tringali, Andrea
Costamagna, Guido
Nonendoscopic transnasal placement
Settore MED/12 - GASTROENTEROLOGIA
Background and study aims: The aim of the study was to evaluate the safety, feasibility, and efficacy of transnasal placement of the Medtronic Bravo capsule for wireless esophageal pH monitoring. Patients and methods: Forty patients with symptomatic gastroesophageal reflux disease were prospectively evaluated. All patients underwent upper gastrointestinal endoscopy and esophageal manometry. The Bravo capsule was then introduced transnasally and released 5 cm above the upper margin of the lower esophageal sphincter. Serial radiographs were performed weekly until capsule release. Results: Of the 40 patients who were evaluated, 38 (95%) were eligible to undergo the procedure. Transnasal placement proved impossible in one patient (2.5%). Overall, a total of 39 procedures were performed in 38 patients (the procedure was repeated in one patient because of accidental intragastric fixation). Esophageal placement was successful in 36/39 procedures (92.3%). The mean duration of the procedure was 10 minutes (range 5-16 minutes). Adverse events were noted in five of the 39 procedures (12.8%), mild epistaxis in two patients (5.1%) and pharyngeal irritation in three patients (7.7%). After the procedure, a slight "foreign body" sensation was reported by 20 of the 36 patients (55.5%) who had undergone successful esophageal placement; two patients (5.5%) experienced severe retrosternal pain necessitating endoscopic removal of the capsule. At the end of the study, 34 of the 38 patients (89.5%) stated that they would be willing to undergo the test again if necessary. Conclusions: Transnasal placement of the Bravo pH capsule is safe, well tolerated, does not require sedation, and avoids endoscopy and its complications. © Georg Thieme Verlag KG Stuttgart.
2006
info:eu-repo/semantics/article
https://hdl.handle.net/10807/250816
10.1055/s-2006-944526
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33748126263
info:eu-repo/semantics/altIdentifier/pmid/17001571
eng
volume:38
issue:8
firstpage:813
lastpage:818
numberofpages:6
issueyear:2006
journal:ENDOSCOPY
oai:publicatt.unicatt.it:10807/2202972023-02-27T11:43:02Zcom_10807_41com_10807_1col_10807_95494
The role of variant rs17618244 of KLB gene in MAFLD-related fibrosis
Panera, N
Miele, L (ORCID:0000-0003-3464-0068)
Panera, N
Meroni, M
Longo, M
Crudele, A
Valenti, L
Bellacchio, E
Miele, L
D'Oria, V
Paolini, E
Maggioni, M
Fracanzani, Al
Alisi, A
Dongiovanni, P
N/A
Settore MED/12 - GASTROENTEROLOGIA
N/A
2021
info:eu-repo/semantics/conferenceObject
https://hdl.handle.net/10807/220297
10.1016/j.dld.2020.12.066
info:eu-repo/semantics/altIdentifier/wos/WOS:000622801600052
eng
volume:53
issue:marzo
firstpage:S25
lastpage:S26
issueyear:2021
journal:DIGESTIVE AND LIVER DISEASE
ELSEVIER SCIENCE INC
oai:publicatt.unicatt.it:10807/2638542024-03-22T19:01:57Zcom_10807_41com_10807_1col_10807_200
The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery
Fransvea, Pietro
Sganga, Gabriele (ORCID:0000-0001-5079-0395)
Crucitti, Antonio (ORCID:0000-0003-3496-4185)
Costa, Gianluca
Bersigotti, Laura
Massa, Giulia
Lepre, Luca
Fransvea, Pietro
Lucarini, Alessio
Mercantini, Paolo
Balducci, Genoveffa
Sganga, Gabriele
Crucitti, Antonio
Emergency surgery
Frailty
Predictive tool
Procedure-specific morbidity
Settore MED/18 - CHIRURGIA GENERALE
Background Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emergency surgery. Study design 1024 patients older than 65 years who required urgent surgical procedures were prospectively recruited from 38 Italian centers participating to the multicentric FRAILESEL (Frailty and Emergency Surgery in the Elderly) study, between December 2016 and May 2017. A univariate analysis was carried out, with the purpose of developing a frailty index in emergency surgery called "EmSFI". Receiver operating characteristic curve analysis was then performed to test the accuracy of our predictive score. Results 784 elderly patients were consecutively enrolled, constituting the development set and results were validated considering further 240 consecutive patients undergoing colorectal surgical procedures. A logistic regression analysis was performed identifying different EmSFI risk classes. The model exhibited good accuracy as regard to mortality for both the development set (AUC = 0.731 [95% CI 0.654-0.772]; HL test chi(2) = 6.780; p = 0.238) and the validation set (AUC = 0.762 [95% CI 0.682-0.842]; HL test chi(2) = 7.238; p = 0.299). As concern morbidity, our model showed a moderate accuracy in the development group, whereas a poor discrimination ability was observed in the validation cohort. Conclusions The validated EmSFI represents a reliable and time-sparing tool, despite its discriminative value decreased regarding complications. Thus, further studies are needed to investigate specifically surgical settings, validating the EmSFI prognostic role in assessing the procedure-related morbidity risk.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/263854
10.1007/s40520-020-01735-5
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85096191610
info:eu-repo/semantics/altIdentifier/pmid/33205380
info:eu-repo/semantics/altIdentifier/wos/WOS:000590206200001
eng
volume:33
issue:8
firstpage:2191
lastpage:2201
numberofpages:11
issueyear:2021
journal:AGING CLINICAL AND EXPERIMENTAL RESEARCH
info:eu-repo/semantics/openAccess
SPRINGER
oai:publicatt.unicatt.it:10807/2603932024-01-10T15:14:21Zcom_10807_41com_10807_1col_10807_200
Non-myeloablative stem cell transplantation for severe combined immunodeficiency--Omenn syndrome
Locatelli, Franco (ORCID:0000-0002-7976-3654)
Rossi, Gabriele
Zecca, Marco
Giorgiani, Giovanna
Bonetti, Federico
De Stefano, Piero
Locatelli, Franco
severe combined immunodeficiency
Omenn syndrome
high transplant-related mortality
high graft rejection
non-myeloablative transplant
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
N/A
2004
info:eu-repo/semantics/article
https://hdl.handle.net/10807/260393
10.1111/j.1365-2141.2004.04906.x
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-2442430560
info:eu-repo/semantics/altIdentifier/pmid/15086425
info:eu-repo/semantics/altIdentifier/wos/WOS:000220857200017
eng
volume:125
issue:3
firstpage:406
lastpage:407
numberofpages:2
issueyear:2004
journal:BRITISH JOURNAL OF HAEMATOLOGY
BLACKWELL PUBLISHING LTD
oai:publicatt.unicatt.it:10807/2315342024-03-19T19:21:18Zcom_10807_41com_10807_1col_10807_200
Imaging alternatives to colonoscopy: CT colonography and colon capsule. European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline - Update 2020
Spada, Cristiano (ORCID:0000-0002-5692-0960)
Hassan, Cesare
Pecere, Silvia
Spada, Cristiano
Hassan, Cesare
Bellini, Davide
Burling, David
Cappello, Giovanni
Carretero, Cristina
Dekker, Evelien
Eliakim, Rami
de Haan, Margriet
Kaminski, Michal F
Koulaouzidis, Anastasio
Laghi, Andrea
Lefere, Philippe
Mang, Thoma
Milluzzo, Sebastian Manuel
Morrin, Martina
Mcnamara, Deirdre
Neri, Emanuele
Pecere, Silvia
Pioche, Mathieu
Plumb, Andrew
Rondonotti, Emanuele
Spaander, Manon Cw
Taylor, Stuart
Fernandez-Urien, Ignacio
van Hooft, Jeanin E
Stoker, Jaap
Regge, Daniele
N/A
Settore MED/12 - GASTROENTEROLOGIA
: 1: ESGE/ESGAR recommend computed tomographic colonography (CTC) as the radiological examination of choice for the diagnosis of colorectal neoplasia.Strong recommendation, high quality evidence.ESGE/ESGAR do not recommend barium enema in this setting.Strong recommendation, high quality evidence. 2: ESGE/ESGAR recommend CTC, preferably the same or next day, if colonoscopy is incomplete. The timing depends on an interdisciplinary decision including endoscopic and radiological factors.Strong recommendation, low quality evidence.ESGE/ESGAR suggests that, in centers with expertise in and availability of colon capsule endoscopy (CCE), CCE preferably the same or the next day may be considered if colonoscopy is incomplete.Weak recommendation, low quality evidence. 3: When colonoscopy is contraindicated or not possible, ESGE/ESGAR recommend CTC as an acceptable and equally sensitive alternative for patients with alarm symptoms.Strong recommendation, high quality evidence.Because of lack of direct evidence, ESGE/ESGAR do not recommend CCE in this situation.Very low quality evidence.ESGE/ESGAR recommend CTC as an acceptable alternative to colonoscopy for patients with non-alarm symptoms.Strong recommendation, high quality evidence.In centers with availability, ESGE/ESGAR suggests that CCE may be considered in patients with non-alarm symptoms.Weak recommendation, low quality evidence. 4: Where there is no organized fecal immunochemical test (FIT)-based population colorectal screening program, ESGE/ESGAR recommend CTC as an option for colorectal cancer screening, providing the screenee is adequately informed about test characteristics, benefits, and risks, and depending on local service- and patient-related factors.Strong recommendation, high quality evidence.ESGE/ESGAR do not suggest CCE as a first-line screening test for colorectal cancer.Weak recommendation, low quality evidence. 5: ESGE/ESGAR recommend CTC in the case of a positive fecal occult blood test (FOBT) or FIT with incomplete or unfeasible colonoscopy, within organized population screening programs.Strong recommendation, moderate quality evidence.ESGE/ESGAR also suggest the use of CCE in this setting based on availability.Weak recommendation, moderate quality evidence. 6: ESGE/ESGAR suggest CTC with intravenous contrast medium injection for surveillance after curative-intent resection of colorectal cancer only in patients in whom colonoscopy is contraindicated or unfeasibleWeak recommendation, low quality evidence.There is insufficient evidence to recommend CCE in this setting.Very low quality evidence. 7: ESGE/ESGAR suggest CTC in patients with high risk polyps undergoing surveillance after polypectomy only when colonoscopy is unfeasible.Weak recommendation, low quality evidence.There is insufficient evidence to recommend CCE in post-polypectomy surveillance.Very low quality evidence. 8: ESGE/ESGAR recommend against CTC in patients with acute colonic inflammation and in those who have recently undergone colorectal surgery, pending a multidisciplinary evaluation.Strong recommendation, low quality evidence. 9: ESGE/ESGAR recommend referral for endoscopic polypectomy in patients with at least one polyp ≥ 6 mm detected at CTC or CCE.Follow-up CTC may be clinically considered for 6 - 9-mm CTC-detected lesions if patients do not undergo polypectomy because of patient choice, comorbidity, and/or low risk profile for advanced neoplasia.Strong recommendation, moderate quality evidence.
2020
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231534
10.1055/a-1258-4819
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85095435170
info:eu-repo/semantics/altIdentifier/pmid/33105507
info:eu-repo/semantics/altIdentifier/wos/WOS:000582505700001
eng
volume:52
issue:12
firstpage:1127
lastpage:1141
numberofpages:15
issueyear:2020
journal:ENDOSCOPY
oai:publicatt.unicatt.it:10807/2310322023-03-29T20:49:36Zcom_10807_41com_10807_1col_10807_200
Estate, tempo di relax matematico?
Elisa Appiani (ORCID:0000-0001-9606-724X)
Laura Montagnoli (ORCID:0000-0001-7424-6538)
Appiani, Elisa
Baresi, Francesca
Montagnoli, Laura
Didattica della matematica
Settore MAT/04 - MATEMATICHE COMPLEMENTARI
In questo contributo vengono presentati agli studenti alcuni suggerimenti per far fruttare al meglio il tempo estivo.
2017
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231032
ita
volume:2016-2017
issue:Aprile
firstpage:86
lastpage:87
numberofpages:2
issueyear:2017
journal:SCUOLA E DIDATTICA
oai:publicatt.unicatt.it:10807/2353162024-03-17T17:40:46Zcom_10807_41com_10807_1col_10807_200
Prospective multicenter study on infectious complications and clinical outcome of 230 unfit acute myeloid leukemia patients receiving first-line therapy with hypomethylating agents alone or in combination with Venetoclax
Dragonetti G.
Pagano L. (ORCID:0000-0001-8287-928X)
Candoni, A.
Lazzarotto, D.
Papayannidis, C.
Piccini, M.
Nadali, G.
Dargenio, M.
Riva, M.
Fracchiolla, N.
Mellillo, L.
Dragonetti, Giulia
Del Principe, M. I.
Cattaneo, C.
Stulle, M.
Pasciolla, C.
De Marchi, R.
Delia, M.
Tisi, M. C.
Bonuomo, V.
Sciume, M.
Spadea, A.
Sartor, C.
Griguolo, D.
Buzzatti, E.
Basilico, C. M.
Sarlo, C.
Piccioni, A. L.
Cerqui, E.
Lessi, F.
Olivieri, A.
Fanin, R.
Luppi, M.
Pagano, Livio
leukemia
Settore MED/15 - MALATTIE DEL SANGUE
no abstract
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/235316
10.1002/ajh.26846
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147567234
info:eu-repo/semantics/altIdentifier/pmid/36651870
info:eu-repo/semantics/altIdentifier/wos/WOS:000934939000001
eng
volume:98
issue:4
firstpage:80
lastpage:83
numberofpages:4
issueyear:2023
journal:AMERICAN JOURNAL OF HEMATOLOGY
John Wiley and Sons Inc
oai:publicatt.unicatt.it:10807/2259722024-03-18T21:13:39Zcom_10807_41com_10807_1col_10807_200
An evaluation of Italian medical students attitudes and knowledge regarding forensic medicine
Aulino, Giovanni
Beccia, Flavia
Rega, Michele
Boccia, Stefania (ORCID:0000-0002-1864-749X)
Lanzone, Antonio (ORCID:0000-0003-4119-414X)
Oliva, Antonio (ORCID:0000-0001-7120-616X)
Aulino, Giovanni
Beccia, Flavia
Siodambro, Chiara
Rega, Michele
Capece, Giuseppe
Boccia, Stefania
Lanzone, Antonio
Oliva, Antonio
Forensic medicine
Medical education
Medical liability
Residency programs
Students
Survey
Settore MED/42 - IGIENE GENERALE E APPLICATA
Introduction: This study aims to assess students' knowledge of forensic medicine concepts and their opinions regarding the course taught during the degree course in Medicine and Surgery in an Italian university. Consequently, the study aims to assess the impact of the course on the students' knowledge and attitude in choosing a medical residency. Materials and methods: A cross-sectional study was conducted through an anonymous web-based survey of medical students at the Università Cattolica del Sacro Cuore. Descriptive and univariate analysis were conducted. Results: 1166 students completed the survey. The forensic medicine course appears to be extremely important in providing training in the fundamental concepts of forensic medicine, especially professional liability, defensive medicine, and forensic pathology. Attending autopsies is important during the course, and their number should be more than ten. Additionally, univariate analysis demonstrates that students' awareness of forensic medicine topics, such as the function of the forensic physicians, professional liability, and defensive medicine, improves in the fifth or sixth year of the course. After the course, more students would choose to pursue a nonclinical and nonsurgical specialty, and forensic medicine specifically, for their residency. Conclusions: The forensic medicine course has the task of defining the duties and responsibilities of forensic physicians, providing indispensable tools for future medical practitioners, regardless of their future specialisation, and limiting the increasing use of defensive medicine. In conclusion, we recommend further multicenter studies to evaluate the role and direct effect of undergraduate forensic medicine courses on students and on the quality of practice.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/225972
10.1016/j.jflm.2023.102484
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147089056
info:eu-repo/semantics/altIdentifier/pmid/36640545
eng
volume:94
issue:2023 Feb;94:102484.
firstpage:102484
lastpage:102488
numberofpages:5
issueyear:2023
journal:JOURNAL OF FORENSIC AND LEGAL MEDICINE
oai:publicatt.unicatt.it:10807/2224022023-06-19T08:09:41Zcom_10807_41com_10807_1col_10807_200
Body Image Quality of Life Inventory: cross-national study in college students from four different countries
Castelnuovo, Gianluca (ORCID:0000-0003-2633-9822)
Pietrabissa, Giada (ORCID:0000-0002-5911-5748)
da Silva, Wanderson Roberto
Pimenta, Filipa
Zaffaroni, Lucia
Castelnuovo, Gianluca
Pietrabissa, Giada
Marôco, João
Maloa, Benvindo Felismino Samuel
Campos, Juliana Alvares Duarte Bonini
Body image
College students
Cross-national
Quality of life
Validation
Settore M-PSI/08 - PSICOLOGIA CLINICA
Purpose This study was aimed to examine the psychometric proprieties of the Body Image Quality of Life Inventory (BIQLI) among Brazilian, Portuguese, Mozambican, and Italian college students. Methods A total of 1630 subjects (Brazilians = 446; Portuguese = 480, Mozambicans = 360, and Italians = 344) completed the Portuguese (Brazilian, Portuguese, and Mozambican students) and the Italian versions (Italian students) of the BIQLI for measuring the effects of body image on one's quality of life. Psychometric testing included confirmatory factor analysis (CFA), discriminant and convergent validity, internal consistency, and composite reliability. The cross-national invariance of the BIQLI was assessed by multi-group analysis using Delta CFI. Moreover, the global score of the BIQLI for all countries was calculated by an algorithm and compared using the Welch's ANOVA and the Games-Howell post-test (alpha = 5%). Results CFA showed an inadequate fit of unifactorial model of the BIQLI. Therefore, an alternative model comprising nine first-order factors and one second-order factor was proposed and evaluated. This new model showed adequate fit in all samples, despite some limitations that were found with respect to its convergent and discriminant validity. The alternative BIQLI model was invariant among countries. Global scores for the influence of body image on quality of life were significantly different across countries, with the Italians presenting the lowest scores. Conclusions The BIQLI factorial model found in this study represents a reliable and valid alternative to its original structure for the assessment of the effect of body image on college students' perceived quality of life. This model must be further tested in other populations.
2020
info:eu-repo/semantics/article
https://hdl.handle.net/10807/222402
10.1007/s40519-019-00732-6
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85068155517
info:eu-repo/semantics/altIdentifier/pmid/31218658
info:eu-repo/semantics/altIdentifier/wos/WOS:000556003800028
eng
volume:25
issue:4
firstpage:1079
lastpage:1088
numberofpages:10
issueyear:2020
journal:EATING AND WEIGHT DISORDERS
SPRINGER
oai:publicatt.unicatt.it:10807/2646542024-03-09T18:31:24Zcom_10807_41com_10807_1col_10807_200
A PRISMA systematic review of greenwashing in the banking industry: A call for action
Paltrinieri, Andrea (ORCID:0000-0002-8172-9199)
Galletta, Simona
Mazzù, Sebastiano
Naciti, Valeria
Paltrinieri, Andrea
Greenwashing
Banks
PRISMA model
Sustainable development
Settore SECS-P/11 - ECONOMIA DEGLI INTERMEDIARI FINANZIARI
This study analyses greenwashing practices in the banking industry using the Preferred Reporting
Items for Systematic Reviews and Meta-analyses (PRISMA) and bibliometric methods. This study
aims to identify the key concerns associated with greenwashing in the banking sector and understand
the extent to which these concerns have been addressed in academic research over the
past decade. This analysis was conducted using the Web of Science and Scopus databases,
resulting in 19 articles identified following the PRISMA protocol. The key findings indicate that
the concept of greenwashing has gained significant attention, with an increasing number of
studies published in recent years. The results of the PRISMA analysis revealed that banks have
been accused of greenwashing by overemphasising sustainable policies and their commitment to
environmental objectives without implementation. This study provides valuable insights into the
nature of greenwashing in the banking industry and offers recommendations for future research.
2024
info:eu-repo/semantics/article
https://hdl.handle.net/10807/264654
10.1016/j.ribaf.2024.102262
eng
volume:69
issue:69
firstpage:1
lastpage:13
numberofpages:13
issueyear:2024
journal:RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE
oai:publicatt.unicatt.it:10807/2316272023-03-31T15:25:43Zcom_10807_41com_10807_1col_10807_200
Il perito e lo straniero = The expert and the foreigners
I. Merzagora
S. Pizzoli (ORCID:0000-0001-9378-8447)
Merzagora Betsos, Isabella
Travaini, G.
Pizzoli, Silvia Francesca Maria
Caruso, P.
surveys foreigners
penal responsability
ethnopsychiatry
Settore M-PSI/05 - PSICOLOGIA SOCIALE
The contribution is intended to analyze problems and practices of imputability assessment of foreigners.
Not only the “tools” that uses the verification within the forensic-psychopathological domain (interview and test) depend on language and culture, but the concept of capacity of discernment itself is largely cultural connoted, as it is even psycho- pathology, to the point that the DSM 5 reserves a specific part to cultural diagnosis.
Within a sample of 51 surveys, carried out on foreigners between 1975 and 2015, the authors assess whether and to what extent professionals have been concerned to take account of the cultural factor in the evaluations, including on the use of psycho-diagnostic techniques.
From the analysis carried out, emerge some difficulties and a substantial lack of attention to defendant’s culture, only rarely assessed and weighed, comes out.
2016
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231627
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85019114843
ita
volume:10
issue:4
firstpage:247
lastpage:256
numberofpages:10
issueyear:2017
journal:RASSEGNA ITALIANA DI CRIMINOLOGIA
oai:publicatt.unicatt.it:10807/2129442024-03-23T22:47:20Zcom_10807_41com_10807_1col_10807_95494
Correction to: CT and MR imaging prior to transcatheter aortic valve implantation: standardisation of scanning protocols, measurements and reporting?a consensus document by the European Society of Cardiovascular Radiology (ESCR) (European Radiology, (2019), 10.1007/s00330-019-06357-8)
Natale, L. (ORCID:0000-0002-7949-5119)
Francone, M.
Budde, R. P. J.
Bremerich, J.
Dacher, J. N.
Loewe, C.
Wolf, F.
Natale, Luigi
Pontone, G.
Redheuil, A.
Vliegenthart, R.
Nikolaou, K.
Gutberlet, M.
Salgado, R.
CT and MR imaging prior to transcatheter aortic valve implantation
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
The original version of this article, published on 05 September 2019, unfortunately contained a mistake. The image of "Jena Valve" in Table 3 was incorrect.
2020
info:eu-repo/semantics/conferenceObject
http://hdl.handle.net/10807/212944
10.1007/s00330-020-06741-9
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85081033967
info:eu-repo/semantics/altIdentifier/pmid/32124024
info:eu-repo/semantics/altIdentifier/wos/WOS:000517704400001
eng
volume:30
issue:7
firstpage:4143
lastpage:4144
numberofpages:2
issueyear:1
journal:EUROPEAN RADIOLOGY
SPRINGER
oai:publicatt.unicatt.it:10807/2559942023-12-02T23:38:38Zcom_10807_41com_10807_1col_10807_200
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
Pitolli, Consuelo
Guerra, Marika
Pieraccioli, Marco
Palluzzi, Fernando
Tamburrini, Gianpiero (ORCID:0000-0002-7139-5711)
Cecconi, Francesco (ORCID:0000-0002-5614-4359)
Sette, Claudio (ORCID:0000-0003-2864-8266)
Pagliarini, Vittoria
Pitolli, Consuelo
Marini, Alberto
Guerra, Marika
Pieraccioli, Marco
Marabitti, Veronica
Palluzzi, Fernando
Giacò, Luciano
Tamburrini, Gianpiero
Cecconi, Francesco
Nazio, Francesca
Sette, Claudio
Pagliarini, Vittoria
Brain tumors
Chemotherapy resistance
RNA polymerase processivity
RNA processing regulation
THZ531
Settore BIO/16 - ANATOMIA UMANA
BackgroundMedulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable. Nevertheless, targeting MYC-dependent processes (i.e. transcription and RNA processing regulation) represents a promising approach.MethodsWe have tested the sensitivity of MYC-driven Group 3 MB cells to a pool of transcription and splicing inhibitors that display a wide spectrum of targets. Among them, we focus on THZ531, an inhibitor of the transcriptional cyclin-dependent kinases (CDK) 12 and 13. High-throughput RNA-sequencing analyses followed by bioinformatics and functional analyses were carried out to elucidate the molecular mechanism(s) underlying the susceptibility of Group 3 MB to CDK12/13 chemical inhibition. Data from International Cancer Genome Consortium (ICGC) and other public databases were mined to evaluate the functional relevance of the cellular pathway/s affected by the treatment with THZ531 in Group 3 MB patients.ResultsWe found that pharmacological inhibition of CDK12/13 is highly selective for MYC-high Group 3 MB cells with respect to MYC-low MB cells. We identified a subset of genes enriched in functional terms related to the DNA damage response (DDR) that are up-regulated in Group 3 MB and repressed by CDK12/13 inhibition. Accordingly, MYC- and CDK12/13-dependent higher expression of DDR genes in Group 3 MB cells limits the toxic effects of endogenous DNA lesions in these cells. More importantly, chemical inhibition of CDK12/13 impaired the DDR and induced irreparable DNA damage exclusively in MYC-high Group 3 MB cells. The augmented sensitivity of MYC-high MB cells to CDK12/13 inhibition relies on the higher elongation rate of the RNA polymerase II in DDR genes. Lastly, combined treatments with THZ531 and DNA damage-inducing agents synergically suppressed viability of MYC-high Group 3 MB cells.ConclusionsOur study demonstrates that CDK12/13 activity represents an exploitable vulnerability in MYC-high Group 3 MB and may pave the ground for new therapeutic approaches for this high-risk brain tumor.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/255994
10.1186/s13046-023-02790-2
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85168428027
info:eu-repo/semantics/altIdentifier/pmid/37599362
info:eu-repo/semantics/altIdentifier/wos/WOS:001050572900002
eng
volume:42
issue:1
firstpage:214
lastpage:N/A
numberofpages:19
issueyear:2023
journal:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
info:eu-repo/semantics/openAccess
BMC
oai:publicatt.unicatt.it:10807/2369182024-03-26T02:40:14Zcom_10807_41com_10807_1col_10807_200
The dynamical Schrödinger problem in abstract metric spaces
Luca Tamanini (ORCID:0000-0002-9179-5990)
Monsaingeon, Léonard
Tamanini, Luca
Vorotnikov, Dmitry
Gradient flows
Metric geometry
Optimal transport
Fisher information
Gamma-convergence
Settore MAT/05 - ANALISI MATEMATICA
In this paper we introduce the dynamical Schrödinger prob-lem, defined for a wide class of entropy and Fisher information functionals, as a geometric problem on abstract metric spaces. Under very mild assumptions we prove a generic Γ-convergence result towards the geodesic problem as the noise parameter ε↓0. We also study the dependence of the entropic cost on the parameter ε. Some examples and applications are discussed.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/236918
10.1016/j.aim.2023.109100
eng
issue:426
firstpage:N/A
lastpage:N/A
numberofpages:N/A
issueyear:2023
journal:ADVANCES IN MATHEMATICS
info:eu-repo/semantics/openAccess
oai:publicatt.unicatt.it:10807/2205962023-06-21T21:50:18Zcom_10807_41com_10807_1col_10807_200
Lower-Limb Muscle Power Is Negatively Associated with Protein Intake in Older Adults: A Cross-Sectional Study
Calvani R. (ORCID:0000-0001-5472-2365)
Tosato M.
Landi F. (ORCID:0000-0002-3472-1389)
Marzetti E. (ORCID:0000-0001-9567-6983)
Coelho-Junior, H. J.
Azzolino, D.
Calvani, Riccardo
Goncalves, I. D. O.
Tosato, Matteo
Landi, Francesco
Cesari, M.
Picca, A.
Marzetti, Emanuele
elderly
frailty
macronutrients
nutrition
physical function
sarcopenia
Humans
Aged
Cross-Sectional Studies
Geriatric Assessment
Muscle, Skeletal
Independent Living
Body Weight
Sarcopenia
Settore MED/09 - MEDICINA INTERNA
The present study examined the association between lower-limb muscle power and protein-related parameters in older adults. This study followed a cross-sectional design. Participants were community-dwelling older adults. Candidates were considered eligible if they were 60 years or older, lived independently, and possessed sufficient physical and cognitive abilities to perform all the measurements required by the protocol. The 5 times sit-to-stand (5STS) test was performed as fast as possible according to a standard protocol. Absolute, relative, and allometric muscle power measures were estimated using 5STS-based equations. Diet was assessed by 24-h dietary recall and diet composition was estimated using a nutritional software. One-hundred and ninety-seven older adults participated to the present study. After adjustment for covariates, absolute and allometric muscle power were negatively associated with body weight-adjusted protein intake. Our findings indicate that absolute and allometric muscle power estimated through a simple equation are negatively associated with body weight-adjusted protein intake in community-dwelling older adults.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/220596
10.3390/ijerph192114579
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141817963
info:eu-repo/semantics/altIdentifier/pmid/36361463
info:eu-repo/semantics/altIdentifier/wos/WOS:000883481100001
eng
volume:19
issue:21
firstpage:1
lastpage:10
numberofpages:10
issueyear:2022
journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
MDPI
oai:publicatt.unicatt.it:10807/2121642024-03-09T17:46:40Zcom_10807_41com_10807_1col_10807_200
Integrating Empirical Analysis and Normative Inquiry in Health Technology Assessment: The Values in Doing Assessments of Health Technologies Approach
Refolo P. (ORCID:0000-0003-1055-160X)
Sacchini D. (ORCID:0000-0002-1581-3018)
Van Der Wilt, G. J.
Bloemen, B.
Grin, J.
Gutierrez-Ibarluzea, I.
Sampietro-Colom, L.
Refolo, Pietro
Sacchini, Dario
Hofmann, B.
Sandman, L.
Oortwijn, W.
Ethics
Policy
Technology assessment biomedical
Settore MED/43 - MEDICINA LEGALE
Health technology assessment (HTA) aims, through empirical analysis, to shed light on the value of health technologies (O'Rourke et al. [2020, International Journal of Technology Assessment in Health Care 36, 187-90]). HTA is, then, where facts and values meet. But how, where, and when do facts and values meet in HTA? Currently, HTA is usually portrayed as a sequential process, starting with empirical analysis (assessment), followed by a deliberation on the implications of the findings for a judgment of a health technology's value (appraisal). In this paper, we will argue that in HTA, empirical analysis and normative inquiry are much more closely entwined. In fact, as we hope to show, normative commitments act as an indispensable guide for the collection and interpretation of empirical evidence. Drawing on policy sciences, we will suggest a concrete methodology that can help HTA practitioners to integrate empirical analysis and normative inquiry in a transparent way. The proposed methodology can be conceived as a concrete means for conducting a scoping exercise in HTA. Moreover, it offers a distinct way of giving stakeholders a structural and constructive role in HTA. This paper outlines the approach developed by the values in doing assessments of health technologies project, a project funded by the Erasmus+ program (contract number 2018-1-NL01-KA203-038960), which is the European Union's program to support education, training, youth, and sport in Europe. The project has resulted in an E-learning course, an accompanying handbook, and a consensus statement, all freely available from the project's website www.validatehta.eu.
2022
info:eu-repo/semantics/article
http://hdl.handle.net/10807/212164
10.1017/S0266462321001768
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133442127
info:eu-repo/semantics/altIdentifier/pmid/35959563
eng
volume:38
issue:1
firstpage:N/A
lastpage:N/A
issueyear:2022
journal:INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
Cambridge University Press
oai:publicatt.unicatt.it:10807/2483352024-03-28T01:34:19Zcom_10807_41com_10807_1col_10807_200
A rare case of digestive tract hemorrhage of extraluminal origin after total gastrectomy|Un raro caso di emorragia digestiva da fonte extraluminale dopo gastrectomia totale
Alfieri S. (ORCID:0000-0002-0404-724X)
Di Miceli D.
Sofo L. (ORCID:0000-0002-0592-5999)
Pacelli F. (ORCID:0000-0002-2013-6525)
Caprino, P.
Alfieri, Sergio
Rotondi, F.
Di Miceli, Dario
Sofo, Luigi
Pacelli, Fabio
Battista Doglietto, G.
tract hemorrhage of extraluminal
Settore MED/18 - CHIRURGIA GENERALE
Abstract
The authors report on a case of digestive bleeding (melaena and enterorrhagia) in a patient undergoing total gastrectomy for gastric cancer and later splenectomy for subcapsular haematoma in a different hospital. The source of bleeding was not intraluminal; the bleeding arose from double erosion of the gastroduodenal artery in the tract above the anterior surface of the pancreas, close to the dehiscent duodenal stump. The blood flowed mainly into the enteric district through the open stump thus causing the clinical signs described. The diagnosis was made during an emergency surgical operation for haemorrhagic shock. The patient underwent haemostasis with two stitches on the gastroduodenal artery, external drainage of the duodenum with a Petzer tube, laparostomy of the infected area and ileostomy. After three months he had completely recovered.
2003
info:eu-repo/semantics/article
https://hdl.handle.net/10807/248335
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0037942823
info:eu-repo/semantics/altIdentifier/pmid/12744109
eng
volume:55
issue:2
firstpage:287
lastpage:290
numberofpages:4
issueyear:2003
journal:CHIRURGIA ITALIANA
oai:publicatt.unicatt.it:10807/2581412023-12-02T23:38:39Zcom_10807_41com_10807_1col_10807_200
La sentenza sul disastro di Rigopiano: "nessun fiocco di neve, in una valanga, si sente mai responsabile"
Dario Quaranta (ORCID:0009-0009-6434-1553)
Quaranta, Dario
Cassazione
Penale
Rigopiano
Omicidio colposo
Disastro
Settore IUS/17 - DIRITTO PENALE
Il presente contributo si sofferma sulle motivazioni della prima sentenza di merito relativa alla tragica vicenda del crollo dell'Hotel Rigopiano. La decisione, nell'affrontare un quadro fattuale e giuridico di estrema complessità, costituisce l'occasione per fronteggiare alcune fondamentali tematiche della parte generale del diritto penale, tra le quali, in particolare, spiccano la posizione di garanzia dei pubblici funzionari, la causalità omissiva e l'elemento soggettivo della colpa.
The paper focuses on the analysis of the first decision relating to the well-known story of the Hotel's Rigopiano collapse. The judgement, wich deals with an extremely complex factual and legal framework, constitutes an opportunity to address some of the fundamental issues of criminal law, such as the guarantee position, the causal link between omission and crime, and fault.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/258141
ita
issue:10
firstpage:3083
lastpage:3107
numberofpages:25
issueyear:2023
journal:CASSAZIONE PENALE
oai:publicatt.unicatt.it:10807/2523382023-09-28T15:52:29Zcom_10807_41com_10807_1col_10807_204
Liti tributarie tardive, via libera delle Entrate alla definizione
Marco Allena (ORCID:0000-0002-5032-3006)
Allena, Marco
Liti Tributarie
--
2023
info:eu-repo/semantics/contributionToPeriodical
https://hdl.handle.net/10807/252338
ita
journal:IL SOLE 24 ORE
oai:publicatt.unicatt.it:10807/2305942024-03-23T00:40:01Zcom_10807_41com_10807_1col_10807_200
Effect of β-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS
Franceschi F. (ORCID:0000-0001-6266-445X)
Purchiaroni F.
Andreozzi P.
Tondi P. (ORCID:0000-0003-1654-2448)
Gasbarrini A. (ORCID:0000-0002-7278-4823)
Gasbarrini G.
Ciacci, C.
Franceschi, Francesco
Purchiaroni, Flaminia
Capone, P.
Buccelletti, F.
Iacomini, P.
Ranaudo, A.
Andreozzi, Paola
Tondi, Paolo
Gentiloni Silveri, N.
Gasbarrini, Antonio
Gasbarrini, Giovanni Battista
n/a
Settore MED/02 - STORIA DELLA MEDICINA
.
2011
info:eu-repo/semantics/article
https://hdl.handle.net/10807/230594
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79960370359
info:eu-repo/semantics/altIdentifier/pmid/21796867
eng
volume:15
issue:6
firstpage:637
lastpage:643
numberofpages:7
issueyear:2011
journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
oai:publicatt.unicatt.it:10807/2579622023-12-02T23:38:40Zcom_10807_41com_10807_1col_10807_200
Bayesian Conjugacy in Probit, Tobit, Multinomial Probit and Extensions: A Review and New Results
Fasano Augusto (ORCID:0000-0002-9734-0583)
Anceschi, Niccolò
Fasano, Augusto
Durante, Daniele
Zanella, Giacomo
Bayesian computation
Data augmentation
Expectation-propagation
Truncated normal distribution
Unified skew-normal distribution
Variational Bayes
Settore SECS-S/01 - STATISTICA
A broad class of models that routinely appear in several fields can be expressed as partially or fully discretized Gaussian linear regressions. Besides including classical Gaussian response settings, this class also encompasses probit, multinomial probit and tobit regression, among others, thereby yielding one of the most widely-implemented families of models in routine applications. The relevance of such representations has stimulated decades of research in the Bayesian field, mostly motivated by the fact that, unlike for Gaussian linear regression, the posterior distribution induced by such models does not seem to belong to a known class, under the commonly assumed Gaussian priors for the coefficients. This has motivated several solutions for posterior inference relying either on sampling-based strategies or on deterministic approximations that, however, still experience computational and accuracy issues, especially in high dimensions. The scope of this article is to review, unify and extend recent advances in Bayesian inference and computation for this core class of models. To address such a goal, we prove that the likelihoods induced by these formulations share a common analytical structure implying conjugacy with a broad class of distributions, namely the unified skew-normal (SUN), that generalize Gaussians to include skewness. This result unifies and extends recent conjugacy properties for specific models within the class analyzed, and opens new avenues for improved posterior inference, under a broader class of formulations and priors, via novel closed-form expressions, iid samplers from the exact SUN posteriors, and more accurate and scalable approximations from variational Bayes and expectation-propagation. Such advantages are illustrated in simulations and are expected to facilitate the routine-use of these core Bayesian models, while providing novel frameworks for studying theoretical properties and developing future extensions. Supplementary materials for this article are available online.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/257962
10.1080/01621459.2023.2169150
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85146268728
info:eu-repo/semantics/altIdentifier/wos/WOS:000944005900001
eng
volume:118
issue:542
firstpage:1451
lastpage:1469
numberofpages:19
issueyear:2023
journal:JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
Taylor and Francis Ltd.
oai:publicatt.unicatt.it:10807/2484942024-03-20T20:55:35Zcom_10807_41com_10807_1col_10807_200
Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients
Di Giorgio, Andrea
Alfieri, Sergio (ORCID:0000-0002-0404-724X)
Di Miceli, Dario
Ridolfini, Marco Pericoli
Rosa, Fausto (ORCID:0000-0002-7280-8354)
Covino, Marcello (ORCID:0000-0002-6709-2531)
Di Giorgio, Andrea
Alfieri, Sergio
Rotondi, Fabio
Prete, Francesco
Di Miceli, Dario
Pericoli Ridolfini, Marco
Rosa, Fausto
Covino, Marcello
Doglietto, Giovanni Battista
tumors of Vater's ampulla
Settore MED/18 - CHIRURGIA GENERALE
Evaluation of prognostic factors of adenocarcinoma of Vater's ampulla is still a matter of debate. The aim of this study was to evaluate retrospectively factors that influence early and long-term outcomes in a 20-year single-institution experience on ampullary carcinoma. A total of 94 consecutive patients with ampullary carcinoma or adenoma with severe dysplasia were managed from 1981 to 2002. Among them, 64 underwent pancreatoduodenectomy, and the remaining 30 submitted to surgical (n = 5) or endoscopic (n = 25) palliative treatment. Demographic, clinical, and pathologic data were collected, and a comparison was made between patients who did or did not undergo resection. Standard statistical analyses were carried out in an attempt to establish a correlation between clinical variables, intraoperative and pathologic factors, and survival in patients with resection. A total of 85 (90.4%) patients had potentially resectable lesions due to the extent of the tumor, but only 64 (68%) underwent curative resection. The surgical morbidity rate was 34.3%. Postoperative mortality was 9.3%, with no deaths among the 38 more recently treated patients. Median survivals were 9 and 54 months for nonresected and resected patients, respectively. The overall 5-year survival was 64.4% for patients undergoing pancreatoduodenectomy. Survival was found to be significantly affected by resection, tumor size, tumor grade, and tumor infiltration. Patients with negative lymph nodes show a trend toward longer survival. In a multivariate analysis, only the depth of tumor infiltration influenced patient survival.Pancreatoduodenectomy is the treatment of choice for ampullary carcinoma and adenomas with high-grade dysplasia, with a good chance of long-term survival. Surgical resection remains the most important factor influencing outcome.
2005
info:eu-repo/semantics/article
https://hdl.handle.net/10807/248494
10.1007/s00268-004-7498-x
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-23444447829
info:eu-repo/semantics/altIdentifier/pmid/15776300
info:eu-repo/semantics/altIdentifier/wos/WOS:000228835800023
eng
volume:29
issue:4
firstpage:513
lastpage:518
numberofpages:6
issueyear:2005
journal:WORLD JOURNAL OF SURGERY
SPRINGER
oai:publicatt.unicatt.it:10807/2225452023-06-20T14:35:25Zcom_10807_41com_10807_1col_10807_200
Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis
Montuschi, Paolo (ORCID:0000-0001-5589-1750)
Takahashi, Kentaro
Pavlidis, Stelio
Ng Kee Kwong, Francoi
Hoda, Uruj
Rossios, Christo
Sun, Kai
Loza, Matthew
Baribaud, Fred
Chanez, Pascal
Fowler, Steve J
Horvath, Ildiko
Montuschi, Paolo
Singer, Florian
Musial, Jacek
Dahlen, Barbro
Dahlen, Sven-Eric
Krug, Norbert
Sandstrom, Thoma
Shaw, Dominic E
Lutter, Rene
Bakke, Per
Fleming, Louise J
Howarth, Peter H
Caruso, Massimo
Sousa, Ana R
Corfield, Julie
Auffray, Charle
De Meulder, Bertrand
Lefaudeux, Diane
Djukanovic, Ratko
Sterk, Peter J
Guo, Yike
Adcock, Ian M
Chung, Kian Fan
severe asthma
U-BIOPRED
sputum proteomics
Settore BIO/14 - FARMACOLOGIA
Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes.The U-BIOPRED cohort of severe asthma patients, containing current-smokers (CSA), ex-smokers (ESA), nonsmokers and healthy nonsmokers was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed.Colony-stimulating factor (CSF) 2 protein levels were increased in CSA sputum supernatants, with azurocidin 1, neutrophil elastase and CXCL8 upregulated in ESA. Phagocytosis and innate immune pathways were associated with neutrophilic inflammation in ESA. Gene set variation analysis of bronchial epithelial cell transcriptome from CSA showed enrichment of xenobiotic metabolism, oxidative stress and endoplasmic reticulum stress compared to other groups. CXCL5 and matrix metallopeptidase 12 genes were upregulated in ESA and the epithelial protective genes, mucin 2 and cystatin SN, were downregulated.Despite little difference in clinical characteristics, CSA were distinguishable from ESA subjects at the sputum proteomic level, with CSA patients having increased CSF2 expression and ESA patients showing sustained loss of epithelial barrier processes.
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/222545
10.1183/13993003.02173-2017
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85047303818
info:eu-repo/semantics/altIdentifier/pmid/29650557
info:eu-repo/semantics/altIdentifier/wos/WOS:000435212900008
eng
volume:51
issue:5
firstpage:1702173
lastpage:N/A
issueyear:2018
journal:EUROPEAN RESPIRATORY JOURNAL
EUROPEAN RESPIRATORY SOC JOURNALS LTD
oai:publicatt.unicatt.it:10807/2291322024-03-15T05:26:15Zcom_10807_41com_10807_1col_10807_200
La piattaforma didattica Revita per l'insegnamento del russo a livello universitario
N. Stoyanova (ORCID:0000-0002-8780-9886)
L. Paracchini
Stoyanova, Nataliya
Paracchini, Laila
Lingua russa
didattica delle lingue straniere
piattaforma didattica
didattica a distanza
Settore L-LIN/21 - SLAVISTICA
In questo articolo viene presentata la piattaforma Revita, ideata e creata dall’università di Helsinki, e viene riferita una esperienza di utilizzo a livello universitario di questa piattaforma digitale per l’insegnamento della lingua russa.
2020
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229132
ita
volume:37
issue:8
firstpage:90
lastpage:94
numberofpages:5
issueyear:2020
journal:NUOVA SECONDARIA
oai:publicatt.unicatt.it:10807/2235922024-03-14T17:36:48Zcom_10807_41com_10807_1col_10807_200
Psychological Impact of COVID-19 on Parents of Pediatric Cancer Patients
Guido, Antonella
Marconi, Elisa
Dinapoli, Nicola
Tamburrini, Gianpiero (ORCID:0000-0002-7139-5711)
Balducci, Mario (ORCID:0000-0003-0398-9726)
Valentini, Vincenzo (ORCID:0000-0003-4637-6487)
Ruggiero, Antonio (ORCID:0000-0002-6052-3511)
Chieffo, Daniela Pia Rosaria
Guido, Antonella
Marconi, Elisa
Peruzzi, Laura
Dinapoli, Nicola
Tamburrini, Gianpiero
Attinà, Giorgio
Balducci, Mario
Valentini, Vincenzo
Ruggiero, Antonio
Chieffo, Daniela Pia Rosaria
COVID-19
cancer
children
parent perception
pediatric oncology
psycho-oncology
quality of life
stress
Settore M-PSI/01 - PSICOLOGIA GENERALE
Settore M-PSI/08 - PSICOLOGIA CLINICA
The changes and general alarm of the current COVID-19 pandemic have amplified the sense of precariousness and vulnerability for family members who, in addition to the emotional trauma of the cancer diagnosis, add the distress and fear of the risks associated with infection. The primary objectives of the present study were to investigate the psychological impact of the COVID-19 pandemic on the parents of pediatric cancer patients, and the level of stress, anxiety, and the child's quality of life perceived by the parents during the COVID-19 epidemic. The parents of 45 consecutive children with solid and hematological tumors were enrolled. Four questionnaires (Impact of Event Scale-Revised - IES-R; Perceived Stress Scale - PSS; Spielberger State - Trait Anxiety Inventory - STAI-Y; Pediatric Quality of Life Inventory - PedsQL) were administered to the parents at the beginning of the pandemic lockdown. A 75% of parents exhibited remarkable levels of anxiety, with 60 subjects in state scale and 45 subjects in trait scale having scores that reached and exceeded the STAI-Y cut off. The bivariate matrix of correlation found a significant positive correlation between the IES-R and PSS scores (r = 0.55, P < 0.001). There was a positive correlation between the PSS and PedsQL (emotional needs) scale (P < 0.001) and a negative correlation between IES-R and STAI-Y (P < 0.001). The results confirm that parents of pediatric cancer patients have a high psychological risk for post-traumatic symptoms, high stress levels, and the presence of clinically significant levels of anxiety.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/223592
10.3389/fpsyg.2021.730341
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85116402701
info:eu-repo/semantics/altIdentifier/pmid/34630243
info:eu-repo/semantics/altIdentifier/wos/WOS:000703917600001
eng
volume:12
issue:September
firstpage:1
lastpage:10
numberofpages:10
issueyear:2021
journal:FRONTIERS IN PSYCHOLOGY
FRONTIERS MEDIA SA
oai:publicatt.unicatt.it:10807/2612022024-01-26T16:48:25Zcom_10807_41com_10807_1col_10807_200
Neo-ECHOTIP: A structured protocol for ultrasound-based tip navigation and tip location during placement of central venous access devices in neonates
Barone, Giovanni
Pittiruti, Mauro (ORCID:0000-0003-4541-7566)
Biasucci, Daniele G
La Greca, Antonio (ORCID:0000-0002-7587-7427)
D’Andrea, Vito (ORCID:0000-0002-0980-799X)
Barone, Giovanni
Pittiruti, Mauro
Biasucci, Daniele Guerino
Elisei, Daniele
Iacobone, Emanuele
La Greca, Antonio
Zito Marinosci, Geremia
D'Andrea, Vito
NICU
Ultrasound
central venous access
epicutano caval catheter
intensive care
newborn
tip location
tip navigation
umbilical venous catheter
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Central venous access devices are often needed in neonates admitted to Neonatal Intensive Care Unit. The location of the tip of the central catheter is usually assessed by post-procedural X-ray. However, this strategy is inaccurate and time consuming. Recent guidelines strongly recommend intra-procedural methods of tip location, to increase the cost-effectiveness of the maneuver and to shorten the time between device placement and utilization. In this regard, real-time ultrasound represents the most promising tool for tip navigation and location in neonates. The aim of this paper is (a) to review all the evidence available about ultrasound-based tip navigation and tip location of central catheters in the neonatal population (b) to propose a novel protocol for tip navigation and location (Neo-ECHOTIP) based on such evidence.
2021
info:eu-repo/semantics/article
https://hdl.handle.net/10807/261202
10.1177/11297298211007703
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85103631306
info:eu-repo/semantics/altIdentifier/pmid/33818191
info:eu-repo/semantics/altIdentifier/wos/WOS:000637142100001
eng
volume:23
issue:5
firstpage:679
lastpage:688
numberofpages:10
issueyear:2022
journal:JOURNAL OF VASCULAR ACCESS
SAGE PUBLICATIONS LTD
oai:publicatt.unicatt.it:10807/2233312024-03-22T23:02:00Zcom_10807_41com_10807_1col_10807_200
Does whole-body hypothermia in neonates with hypoxic-ischemic encephalopathy affect surfactant disaturated- phosphatidylcholine kinetics?
Stefano Nobile (ORCID:0000-0002-5304-1485)
Nespeca, Matteo
Giorgetti, Chiara
Nobile, Stefano
Ferrini, Ilaria
Simonato, Manuela
Verlato, Giovanna
Cogo, Paola
Paolo Carnielli, Virgilio
N/A
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Background It is unknown whether Whole-Body Hypothermia (WBH) affects pulmonary function. In vitro studies, at relatively low temperatures, suggest that hypothermia may induce significant changes to the surfactant composition. The effect of WBH on surfactant kinetics in newborn infants is unknown. We studied in vivo kinetics of disaturated-phosphatidylcholine (DSPC) in asphyxiated newborns during WBH and in normothermic controls (NTC) with no or mild asphyxia. Both groups presented no clinically apparent lung disease. Methods Twenty-seven term or near term newborns requiring mechanical ventilation were studied (GA 38.6±2.2 wks). Fifteen during WBH and twelve NTC. All infants received an intra-tracheal dose of 13C labelled DSPC and tracheal aspirate were performed. DSPC amount, DSPC half-life (HL) and pool size (PS) were calculated. Results DSPC amount in tracheal aspirates was 0.42 [0.22-0.54] and 0.36 [0.10-0.58] mg/ml in WBH and NTC respectively (p = 0.578). DSPC HL was 24.9 [15.7-52.5] and 25.3 [15.8- 59.3] h (p = 0.733) and DSPC PS was 53.2 [29.4-91.6] and 40.2 [29.8-64.6] mg/kg (p = 0.598) in WBH and NTC respectively. Conclusions WBH does not alter DSPC HL and PS in newborn infants with no clinical apparent lung disease.
2016
info:eu-repo/semantics/article
https://hdl.handle.net/10807/223331
10.1371/journal.pone.0153328
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84963726020
info:eu-repo/semantics/altIdentifier/pmid/27070307
info:eu-repo/semantics/altIdentifier/wos/WOS:000373900700052
eng
volume:11
issue:4
firstpage:N/A
lastpage:N/A
issueyear:2016
journal:PLOS ONE
Public Library of Science
oai:publicatt.unicatt.it:10807/2284162024-03-23T21:37:10Zcom_10807_41com_10807_1col_10807_200
Reactivity of Indolylmethylacetates with N, O, and S Soft Nucleophiles: Evidence of 2-Alkylideneindolenines and 3-Alkylideneindoleninium Generation by ESI-MS and IRMPD Spectroscopy
Iazzetti, A (ORCID:0000-0002-7792-774X)
Arcadi, A
Berden, G
Ciogli, A
Corinti, D
Crestoni, Me
De Angelis, M
Fabrizi, G
Goggiamani, A
Iazzetti, Antonia
Marrone, F
Marsicano, V
Oomens, J
Serraiocco, A
Carbinols
Indole-2-methides
IRMPD
Nitrogen heterocycles
Synthetic methods
Settore CHIM/06 - CHIMICA ORGANICA
The synthesis of (aminomethyl), (tosylmethyl), and (aryloxymethyl) indoles starting from indolylmethylacetates and N, O, and S soft nucleophiles has been developed. ESI-MS and IR multiple-photon dissociation (IRMPD) spectroscopy analyses confirm the reaction proceeds through a conjugate addition of the nucleophile to 2-alkylideneindolenines and 3-alkylideneindoleninium.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/228416
10.1002/ejoc.202201166
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142364350
info:eu-repo/semantics/altIdentifier/wos/WOS:000884495100001
eng
volume:2022
issue:43
firstpage:1
lastpage:10
numberofpages:10
issueyear:2022
journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
WILEY-V C H VERLAG GMBH
oai:publicatt.unicatt.it:10807/2506392024-03-23T18:03:54Zcom_10807_41com_10807_1col_10807_200
Performance measures for endoscopic retrograde cholangiopancreatography and endoscopic ultrasound: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Tringali A. (ORCID:0000-0002-9614-3449)
Hassan C.
Spada C. (ORCID:0000-0002-5692-0960)
Domagk, D.
Oppong, K. W.
Aabakken, L.
Czako, L.
Gyokeres, T.
Manes, G.
Meier, P.
Poley, J. -W.
Ponchon, T.
Tringali, Andrea
Bellisario, C.
Minozzi, S.
Senore, C.
Bennett, C.
Bretthauer, M.
Hassan, Cesare
Kaminski, M. F.
Dinis-Ribeiro, M.
Rees, C. J.
Spada, Cristiano
Valori, R.
Bisschops, R.
Rutter, M. D.
ERCP
EUS
EUS-FNA
Performance measures
quality
quality indicators
Settore MED/12 - GASTROENTEROLOGIA
The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology present a short list of key performance measures for endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP). We recommend that endoscopy services across Europe adopt the following seven key and one minor performance measures for EUS and ERCP, for measurement and evaluation in daily practice at centre and endoscopist level: 1 Adequate antibiotic prophylaxis before ERCP (key performance measure, at least 90%); 2 antibiotic prophylaxis before EUS-guided puncture of cystic lesions (key performance measure, at least 95%); 3 bile duct cannulation rate (key performance measure, at least 90%); 4 tissue sampling during EUS (key performance measure, at least 85%); 5 appropriate stent placement in patients with biliary obstruction below the hilum (key performance measure, at least 95%); 6 bile duct stone extraction (key performance measure, at least 90%); 7 post-ERCP pancreatitis (key performance measure, less than 10%); and 8 adequate documentation of EUS landmarks (minor performance measure, at least 90%). This present list of quality performance measures for ERCP and EUS recommended by the ESGE should not be considered to be exhaustive; it might be extended in future to address further clinical and scientific issues.
2018
info:eu-repo/semantics/article
https://hdl.handle.net/10807/250639
10.1177/2050640618808157
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85058088704
info:eu-repo/semantics/altIdentifier/wos/WOS:000453103700002
eng
volume:6
issue:10
firstpage:1448
lastpage:1460
numberofpages:13
issueyear:2018
journal:UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
SAGE Publications Ltd
oai:publicatt.unicatt.it:10807/2315622023-06-21T12:16:34Zcom_10807_41com_10807_1col_10807_200
Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e Interventistica (SIRM), Società Italiana di Chirurgia (SIC), Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB), Associazione Italiana di Chirurgia Epatobilio-Pancreatica (AICEP), Società Italiana Trapianti d'Organo (SITO), Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPEC-IAP) – Part II - Solid lesions
Pompili M. (ORCID:0000-0001-6699-7980)
Ardito F. (ORCID:0000-0003-1596-2862)
Santopaolo F.
Pompili, Maurizio
Ardito, Francesco
Brunetti, E.
Cabibbo, G.
Calliada, F.
Cillo, U.
de Sio, I.
Golfieri, R.
Grova, M.
Gruttadauria, S.
Guido, M.
Iavarone, M.
Manciulli, T.
Pagano, D.
Pettinari, I.
Santopaolo, Francesco
Soresi, M.
Colli, A.
Focal liver lesion
Focal nodular hyperplasia
Hepatic hemangioma
Hepatocellular adenoma
Settore MED/18 - CHIRURGIA GENERALE
Benign liver lesions are increasingly diagnosed in daily clinical practice due to the growing use of imaging techniques for the study of the abdomen in patients who have non-specific symptoms and do not have an increased risk of hepatic malignancy. They include simple or parasitic hepatic cysts and solid benign tumors which differ widely in terms of prevalence, clinical relevance, symptoms and natural history and often lead to significant clinical problems relating to diagnosis and clinical management. Following the need to have updated guidelines on the management of benign focal liver lesions, the Scientific Societies mainly involved in their management have promoted the drafting of a new dedicated document. This document was drawn up according to the present Italian rules and methodologies necessary to produce clinical, diagnostic, and therapeutic guidelines based on evidence. Here we present the second part of the guideline, concerning the diagnosis and clinical management of hemangioma, focal nodular hyperplasia, and hepatocellular adenoma.
2022
info:eu-repo/semantics/article
https://hdl.handle.net/10807/231562
10.1016/j.dld.2022.08.031
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137704722
info:eu-repo/semantics/altIdentifier/pmid/36089523
info:eu-repo/semantics/altIdentifier/wos/WOS:000923156600003
eng
volume:54
issue:12
firstpage:1614
lastpage:1622
numberofpages:9
issueyear:2022
journal:DIGESTIVE AND LIVER DISEASE
Elsevier B.V.
oai:publicatt.unicatt.it:10807/2622982024-03-24T07:55:18Zcom_10807_41com_10807_1col_10807_200
Combined evaluation of prolactin-induced peptide (PIP) and extracellular signal-regulated kinase (ERK) as new sperm biomarkers of FSH treatment efficacy in normogonadotropic idiopathic infertile men
Teveroni E.
Vergani E.
Bianchetti G.
Grande G.
Iavarone F. (ORCID:0000-0002-2074-5531)
Maulucci G. (ORCID:0000-0002-2154-319X)
De Spirito M. (ORCID:0000-0003-4260-5107)
Urbani A. (ORCID:0000-0001-9168-3174)
Pontecorvi A. (ORCID:0000-0003-0570-6865)
Milardi D.
Mancini, F.
Di Nicuolo, F.
Teveroni, Emanuela
Vergani, Edoardo
Bianchetti, Giada
Bruno, C.
Grande, Giuseppe
Iavarone, Federica
Maulucci, Giuseppe
De Spirito, Marco
Urbani, Andrea
Pontecorvi, Alfredo
Milardi, Domenico
ERK1/2
FSH
FSH treatment
Idiopathic infertility
PIP
Spermatozoa
Settore BIO/10 - BIOCHIMICA
PurposeNearly, 40% of the causes of male infertility remain idiopathic. The only suggested treatment in idiopathic oligo- and/or asthenozoospermia in normogonadotropic patients is the FSH. In the current clinical practice, efficacy is exclusively assessable through semen analysis after 3 months of treatment. No molecular markers of treatment efficacy are appliable in clinical practice. The aim of the present work is to evaluate the combination of extracellular signal regulated kinase (ERK) 1 and 2 and prolactin inducible peptide (PIP) as potential markers of idiopathic infertility and FSH treatment efficacy.MethodsWestern blot and confocal microscopy were performed to analyze the modulation of PIP and ERK1/2 in idiopathic infertile patients (IIP) sperm cells. Taking advantage of mass spectrometry analysis, we identified these proteins unequivocally in sperm cells.Results We demonstrated a significant decrease of both PIP protein and of ERK1/2 levels in spermatozoa obtained from IIP in comparison to healthy fertile patients (HFP). Conversely, we reported a significant increase of these markers comparing infertile patients before and after 3 months of FSH treatment. Importantly, this correlated with an increase in total number of sperm and sperm motility after FSH treatment. Finally, we identified of PIP and ERK2 proteins in sperm samples by proteomic analysis.ConclusionsThe combined evaluation of ERK1/2 and PIP proteins might represent a useful molecular marker to tailor FSH treatment in the management of male normogonadotropic idiopathic infertility.
2023
info:eu-repo/semantics/article
https://hdl.handle.net/10807/262298
10.1007/s40618-023-02161-w
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85165560495
info:eu-repo/semantics/altIdentifier/pmid/37480475
info:eu-repo/semantics/altIdentifier/wos/WOS:001032359100001
eng
volume:47
issue:2
firstpage:455
lastpage:468
numberofpages:14
issueyear:2023
journal:JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
SPRINGER
oai:publicatt.unicatt.it:10807/2295352024-03-15T19:54:14Zcom_10807_41com_10807_1col_10807_200
Outcome of children with acute leukemia given HLA-haploidentical HSCT after ab T-cell and B-cell depletion
Locatelli F. (ORCID:0000-0002-7976-3654)
Locatelli, Franco
Merli, P.
Pagliara, D.
Li Pira, G.
Falco, M.
Pende, D.
Rondelli, R.
Lucarelli, B.
Brescia, L. P.
Masetti, R.
Milano, G. M.
Bertaina, V.
Algeri, M.
Pinto, R. M.
Strocchio, L.
Meazza, R.
Grapulin, L.
Handgretinger, R.
Moretta, A.
Bertaina, A.
Moretta, L.
HSCT
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-haploidentical relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either relapsed or at high-risk of treatment failure. We developed a novel method of graft manipulation based on negative depletion of ab T and B cells and conducted a prospective trial evaluating the outcome of children with AL transplanted with this approach. Eighty AL children, transplanted between September 2011 and September 2014, were enrolled in the trial. All children were given a fully myeloablative preparative regimen. Anti–T-lymphocyte globulin from day 25 to 23 was used for preventing graft rejection and graft-versus-host disease (GVHD); no patient received any posttransplantation GVHD prophylaxis. Two children experienced primary graft failure. The cumulative incidence of skin-only, grade 1-2 acute GVHD was 30%; no patient developed extensive chronic GVHD. Four patients died, the cumulative incidence of nonrelapse mortality being 5%, whereas 19 relapsed, resulting in a 24% cumulative incidence of relapse. With a median follow-up of 46 months for surviving patients, the 5-year probability of chronic GVHD-free, relapse-free survival (GRFS) is 71%. Total body irradiation–containing preparative regimen was the only variable favorably influencing relapse incidence and GRFS. The outcomes of these 80 patients are comparable to those of 41 and 51 children given transplantation from an HLA-identical sibling or a 10/10 allelic-matched unrelated donor in the same period. These data indicate that haplo-HSCT after ab T- and B-cell depletion represents a competitive alternative for children with AL in need of urgent allograft. This trial was registered at www.clinicaltrials.gov as #NCT01810120.
2017
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229535
10.1182/blood-2017-04-779769
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85026725251
info:eu-repo/semantics/altIdentifier/pmid/28588018
info:eu-repo/semantics/altIdentifier/wos/WOS:000406875400016
eng
volume:130
issue:5
firstpage:677
lastpage:685
numberofpages:9
issueyear:2017
journal:BLOOD
American Society of Hematology
oai:publicatt.unicatt.it:10807/2299082024-03-18T19:17:21Zcom_10807_41com_10807_1col_10807_200
Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor
Locatelli F. (ORCID:0000-0002-7976-3654)
Bertaina, A.
Zorzoli, A.
Petretto, A.
Barbarito, G.
Inglese, E.
Merli, P.
Lavarello, C.
Brescia, L. P.
De Angelis, B.
Tripodi, G.
Moretta, L.
Locatelli, Franco
Airoldi, I.
haematopoietic stem cell transplantation
leukemic patients
proteomic
zoledronic acid
γδ T cells
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
We demonstrated that γδ T cells of patients given HLA-haploidentical HSCT after removal of αβ+ T cells and CD19+ B cells are endowed with the capacity of killing leukemia cells after ex vivo treatment with zoledronic acid (ZOL). Thus, we tested the hypothesis that infusion of ZOL in patients receiving this type of graft may enhance γδ T-cell cytotoxic activity against leukemia cells. ZOL was infused every 28 d in 43 patients; most were treated at least twice. γδ T cells before and after ZOL treatments were studied in 33 of these 43 patients, till at least 7 mo after HSCT by high-resolution mass spectrometry, flow-cytometry, and degranulation assay. An induction of Vδ2-cell differentiation, paralleled by increased cytotoxicity of both Vδ1 and Vδ2 cells against primary leukemia blasts was associated with ZOL treatment. Cytotoxic activity was further increased in Vδ2 cells, but not in Vδ1 lymphocytes in those patients given more than one treatment. Proteomic analysis of γδ T cells purified from patients showed upregulation of proteins involved in activation processes and immune response, paralleled by downregulation of proteins involved in proliferation. Moreover, a proteomic signature was identified for each ZOL treatment. Patients given three or more ZOL infusions had a better probability of survival in comparison to those given one or two treatments (86% vs. 54%, respectively, p = 0.008). Our data indicate that ZOL infusion in pediatric recipients of αβ T- and B-cell-depleted HLA-haploidentical HSCT promotes γδ T-cell differentiation and cytotoxicity and may influence the outcome of patients.
2017
info:eu-repo/semantics/article
https://hdl.handle.net/10807/229908
10.1080/2162402X.2016.1216291
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011278091
info:eu-repo/semantics/altIdentifier/pmid/28344861
info:eu-repo/semantics/altIdentifier/wos/WOS:000397987000005
eng
volume:6
issue:2
firstpage:e1216291-1
lastpage:e1216291-15
issueyear:2017
journal:ONCOIMMUNOLOGY
Taylor and Francis Inc.
oai_dc///com_10807_41/100