Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).
Tecchio, F., Vecchio, F., Ventriglia, M., Porcaro, C., Miraglia, F., Siotto, M., Rossini, P. M., Rongioletti, M., Squitti, R., Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity, <<CURRENT ALZHEIMER RESEARCH>>, 2016; 13 (12): 1374-1384. [doi:10.2174/1567205013666160603001131] [http://hdl.handle.net/10807/92782]
Non-Ceruloplasmin Copper Distinguishes A Distinct Subtype of Alzheimer's Disease: A Study of EEG-Derived Brain Activity
Vecchio, FabrizioSecondo
;Miraglia, Francesca;Rossini, Paolo Maria;
2016
Abstract
Meta-analyses show that percentages of non-Cp-Cu-copper that is not bound to ceruloplasmin (also known as 'free' copper)-in serum are higher in Alzheimer's disease (AD) patients. Genetic heterogeneity in AD patients stratified on the basis of non-Cp-Cu cut-off sustains the existence of a copper AD metabolic subtype. Non-Cp-Cu abnormalities correlated with alterations of electroencephalographic rhythms (EEG).
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