Aims: Low-dose radiation therapy (LDRT) can increase biological efficacy of chemotherapy. This Phase II trial evaluates LDRT plus FOLFIRI-bevacizumab (FOLFIRI-B) in metastatic colorectal cancer. Materials & methods: Primary objective: raising the clinical complete response rate from 5 to 25%. Secondary objectives: toxicity, progression-free survival. Patients underwent 12 FOLFIRI-B cycles plus two daily LDRT fractions (20 cGy/6 h interval) on each cycle. Statistical analysis was planned on 18 patients. Results: Results on 18 patients are reported. Specifically considering irradiated sites: 15/18 patients had a partial (11/18) or complete (4/18) response. Among 11 partial responders, three became a pathological CR after surgery. Grade 3-4 toxicity was recorded in two patients (11.1%). At median follow-up of 30 months (range: 8-50), 7/18 patients progressed in irradiated sites. Conclusion: Seven out of 18 patients (38.9%) had clinical or pathological CR in lesions treated with LDRT. Further studies on this newer treatment modality seem justified.
Morganti, A. G., Cellini, F., Mignogna, S., Padula, G. D., Caravatta, L., Deodato, F., Picardi, V., Macchia, G., Cilla, S., Buwenge, M., Lullo, L. D., Gambacorta, M. A., Balducci, M., Mattiucci, G. C., Autorino, R., Valentini, V., Low-dose radiotherapy and concurrent FOLFIRI-bevacizumab: A Phase II study, <<FUTURE ONCOLOGY>>, 2016; 12 (6): 779-787. [doi:10.2217/fon.15.350] [http://hdl.handle.net/10807/92456]
Low-dose radiotherapy and concurrent FOLFIRI-bevacizumab: A Phase II study
Morganti, Alessio GiuseppePrimo
;Cellini, Francesco
;Mignogna, Samantha;Caravatta, Luciana;Deodato, Francesco;Picardi, Vincenzo;Cilla, Savino;Gambacorta, Maria Antonietta;Balducci, Mario;Mattiucci, Gian Carlo;Autorino, RosaPenultimo
;Valentini, VincenzoUltimo
2016
Abstract
Aims: Low-dose radiation therapy (LDRT) can increase biological efficacy of chemotherapy. This Phase II trial evaluates LDRT plus FOLFIRI-bevacizumab (FOLFIRI-B) in metastatic colorectal cancer. Materials & methods: Primary objective: raising the clinical complete response rate from 5 to 25%. Secondary objectives: toxicity, progression-free survival. Patients underwent 12 FOLFIRI-B cycles plus two daily LDRT fractions (20 cGy/6 h interval) on each cycle. Statistical analysis was planned on 18 patients. Results: Results on 18 patients are reported. Specifically considering irradiated sites: 15/18 patients had a partial (11/18) or complete (4/18) response. Among 11 partial responders, three became a pathological CR after surgery. Grade 3-4 toxicity was recorded in two patients (11.1%). At median follow-up of 30 months (range: 8-50), 7/18 patients progressed in irradiated sites. Conclusion: Seven out of 18 patients (38.9%) had clinical or pathological CR in lesions treated with LDRT. Further studies on this newer treatment modality seem justified.
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