The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.
De Candia, A., Gamba, A., Cavalli, F., Coniglio, A., Di Talia, S., Bussolino, F., Serini, G., A simulation environment for directional sensing as a phase separation process, <<SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT>>, 2007; 2007 (378): N/A-N/A. [doi:10.1126/stke.3782007pl1] [http://hdl.handle.net/10807/85717]
A simulation environment for directional sensing as a phase separation process
Cavalli, Fausto;
2007
Abstract
The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.
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