Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
Frisullo, G., Plantone, D., Marti, A., Iorio, R., Nociti, V., Patanella, A. K., Batocchi, A. P., Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2011; 2011 (Dicembre): 137-141 [http://hdl.handle.net/10807/7772]
Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients
Frisullo, Giovanni;Plantone, Domenico;Marti, Alessandro;Iorio, Raffaele;Nociti, Viviana;Patanella, Agata Katia;Batocchi, Anna Paola
2011
Abstract
Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
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