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EnglishRelapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
Frisullo, G., Plantone, D., Marti, A., Iorio, R., Nociti, V., Patanella, A. K., Batocchi, A. P., Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2011; 2011 (Dicembre): 137-141 [http://hdl.handle.net/10807/7772]
| Autori: | ||
| Titolo: | Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients | |
| Data di pubblicazione: | 2011 | |
| Abstract: | Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Frisullo, G., Plantone, D., Marti, A., Iorio, R., Nociti, V., Patanella, A. K., Batocchi, A. P., Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2011; 2011 (Dicembre): 137-141 [http://hdl.handle.net/10807/7772] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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