Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.
Mormando, M., Nasto, L., Bianchi, A., Mazziotti, G., Giampietro, A., Pola, E., Pontecorvi, A., Giustina, A., De Marinis Grasso, L., GH receptor isoforms and skeletal fragility in acromegaly, <<EUROPEAN JOURNAL OF ENDOCRINOLOGY>>, 2014; 171 (2): 237-245. [doi:10.1530/EJE-14-0205] [http://hdl.handle.net/10807/66772]
GH receptor isoforms and skeletal fragility in acromegaly
Mormando, Marilda;Bianchi, Antonio;Giampietro, Antonella;Pola, Enrico;Pontecorvi, Alfredo;De Marinis Grasso, Laura
2014
Abstract
Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
