Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.
Maranghi, M., Prudente, S., D'Erasmo, L., Morini, E., Ciociola, E., Coletta, P., Verrienti, A., Arciello, S., Copetti, M., Pellegrini, F., Santini, S. A., Morano, S., Filetti, S., Trischitta, V., The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals, <<NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES>>, 2013; 23 (6): 505-510. [doi:10.1016/j.numecd.2011.11.003] [http://hdl.handle.net/10807/63744]
The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals
Santini, Stefano Angelo;
2013
Abstract
Several studies have reported that the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K121Q polymorphism (rs1044498) interacts with increased adiposity in affecting glucose homeostasis and insulin sensitivity. Conversely, one would expect that the amelioration of glucose homeostasis observed after weight loss is modulated by the ENPP1 K121Q polymorphism. The aim of our study was to test such hypothesis, in non-diabetic overweight-obese individuals.
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