A 63-year-old woman underwent F-FDG PET/CT searching for the cause of a fever of unknown origin. F-FDG PET/CT incidentally detected a focal area of markedly increased radiopharmaceutical uptake in the right adrenal gland; this finding was suspicious for an adrenal malignancy or a functioning adenoma. Nevertheless, histology and laboratory data demonstrated the presence of a nonfunctioning adenoma. This case highlights that nonfunctioning adrenal adenomas should be considered as possible false-positive F-FDG PET/CT findings for malignancy in the evaluation of adrenal incidentalomas, even when marked F-FDG uptake is revealed.
Treglia, G., Oragano, L., Fadda, G., De Gaetano, A. M., Raffaelli, M., Rufini, V., Markedly Increased 18F-FDG Uptake in a Nonfunctioning Adrenal Adenoma Mimicking Malignancy, <<CLINICAL NUCLEAR MEDICINE>>, 2013; 38 (8): e333-e335. [doi:10.1097/RLU.0b013e318279f389] [http://hdl.handle.net/10807/43361]
Markedly Increased 18F-FDG Uptake in a Nonfunctioning Adrenal Adenoma Mimicking Malignancy
Treglia, Giorgio;Oragano, Luigi;Fadda, Guido;De Gaetano, Anna Maria;Raffaelli, Marco;Rufini, Vittoria
2013
Abstract
A 63-year-old woman underwent F-FDG PET/CT searching for the cause of a fever of unknown origin. F-FDG PET/CT incidentally detected a focal area of markedly increased radiopharmaceutical uptake in the right adrenal gland; this finding was suspicious for an adrenal malignancy or a functioning adenoma. Nevertheless, histology and laboratory data demonstrated the presence of a nonfunctioning adenoma. This case highlights that nonfunctioning adrenal adenomas should be considered as possible false-positive F-FDG PET/CT findings for malignancy in the evaluation of adrenal incidentalomas, even when marked F-FDG uptake is revealed.
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